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cloning of the gene and cDNA encoding cGnRH-II from zebrafish; in situ hybridization analysis of expression in adult zebrafish brains; levels quantified in the pituitary
GnRH loss-of-function affects early brain and eye formation during development.
results suggest GnRH-II-induced laminin receptor precursor expression increases 67-kDa nonintegrin laminin receptor, which appears to interact with laminin in the extracellular matrix to promote MMP-2 (显示 MMP2 蛋白) expression and enhance ovarian cancer cell invasion
concluded that GnRHII stimulates PI3K (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) pathway, and the phosphorylation of glycogen synthase kinase3beta, thereby enhancing the beta-catenin (显示 CTNNB1 蛋白)-dependent up-regulation of MT1-MMP (显示 MMP14 蛋白) production which contributes to ovarian cancer metastasis
These preliminary data suggest that local GnRH-II may participate in the regulation of ovarian tumor growth in post-menopausal women.
GnRH-II and GnRH-I (显示 GNRH1 蛋白) interact directly with T cells and trigger gene transcription, adhesion, chemotaxis and homing to specific organs, which may be of clinical relevance.
a novel mechanism in stimulating basal human GnRH-II gene transcription mediated by cooperative actions of multiple regulatory elements within the untranslated first exon of the gene.
regulation of GnRH-I (显示 GNRH1 蛋白) and GnRH-II gene expression in the ovary
gonadotropin releasing hormone-II is more effective than gonadotropin releasing hormone-I in stimulating leptin (显示 LEP 蛋白) secretion
GnRH-II has been identified, together with a 'putative' type II GnRH receptor, both in the central nervous system and in peripheral structures, such as tissues of the reproductive tract (both normal and tumoral).
GnRH I (显示 GNRH1 蛋白) and GnRH II have both common and discrete cellular distributions in the placenta and decidua and suggest that these two hormones are capable of eliciting their biological actions in an autocrine and/or paracrine manner
Progesterone receptor (显示 PGR 蛋白) isoform p4 is a potent regulator of GnRHRI at the transcriptional level as well as GnRH I (显示 GNRH1 蛋白) mRNA.
The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene.
cII gonadotropin releasing hormone
, gonadotropin-releasing hormone 2
, GnRHII precursor-like protein
, chicken-II-type gonadotropin-releasing hormone
, progonadoliberin II
, luliberin II
, luteinizing hormone-releasing hormone II
, GnRH-associated peptide II
, chicken luteinizing hormone-releasing hormone II
, gonadoliberin II