anti-DIO3 (DIO3) 抗体产品概述

Mouse (Murine) Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

1. Results demonstrate that DIO3 is essential for normal aggression and maternal behaviors, and indicate that abnormal local regulation of thyroid hormone (显示 PTH 抗体) action in the brain may contribute to the social deficits associated with neurodevelopmental disorders.

2. Functional analysis revealed that ground-state miRNAs embedded in the Dlk1 (显示 DLK1 抗体)-Dio3 locus (miR (显示 MLXIP 抗体)-541-5p, miR (显示 MLXIP 抗体)-410-3p, and miR (显示 MLXIP 抗体)-381-3p) promoted pluripotency via inhibition of multi-lineage differentiation and stimulation of self-renewal

3. Results indicate that basal cell carcinoma cells constitute an example in which the thyroid hormone (显示 PTH 抗体) signal is finely tuned by the concerted expression of opposite-acting deiodinases. The dual regulation of Dio2 (显示 DIO2 抗体) and Dio3 expression plays a critical role in cell cycle progression and cell death by influencing cyclin D1 (显示 CCND1 抗体)-mediated entry into the G1-S phase.

4. Gene body methylation of noncoding RNA genes was observed and among these microRNA genes were prominent. Of particular note, observed only in hyperphenylalaninemic animals, was hypomethylation of miRNA genes within the imprinted Dlk1 (显示 DLK1 抗体)-Dio3 locus on chromosome 12.

5. Dio3-/- mice display degeneration of retinal cones, the photoreceptors that mediate daylight and color vision. In Dio2 (显示 DIO2 抗体)-/- mice, cone function was largely normal but deletion of Dio2 (显示 DIO2 抗体) in Dio3-/- mice markedly recovered cone numbers and electroretinogram responses, suggesting counterbalancing roles for both enzymes in cone survival.

6. The marked phenotypic abnormalities observed in the D3-deficient mouse, including perinatal mortality, growth retardation, and central hypothyroidism in adult animals, require expression of MCT8 (显示 MCT8 抗体), confirming the interdependent relationship between the TH transport into cells and the deiodination processes.

7. The brain-specific (显示 CALY 抗体) miR (显示 MLXIP 抗体)-379/miR (显示 MLXIP 抗体)-410 gene cluster at the imprinted Dlk1 (显示 DLK1 抗体)-Dio3 domain is implicated in several aspects of brain development and function.

8. DNA methylation (显示 HELLS 抗体) regulates genomic imprinted DLK1 (显示 DLK1 抗体)-Dio3 miRNAs in autoimmune lupus

9. identify the molecular regulators involved in the recruitment of AFF3 (显示 AFF3 抗体) to gDMRs and provide mechanistic insight into the requirement of AFF3 (显示 AFF3 抗体) at an enhancer for the expression of an approximately 200-kb polycistronic transcript within the imprinted Dlk1 (显示 DLK1 抗体)-Dio3 locus

10. Dppa3 (显示 DPPA3 抗体) has a critical role in generation of fully reprogrammed iPS (显示 SLC27A4 抗体) cells and maintenance of Dlk1 (显示 DLK1 抗体)-Dio3 imprinting

Xenopus laevis Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

1. No changes in TRb or DI-2 and DI-3 expression in tail tissue collected from Triclosan exposure larvae were found.

Human Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

1. The expression of DIO3 on mRNA/protein levels in the depressive disorders patients was increased in comparison to the control subjects.

2. The expression of piRNAs encoded at DLK1 (显示 DLK1 抗体)-DIO3 enhances the prognostic potential of small non-coding RNAs specific to this locus in predicting lung cancer patient outcome.

3. In neonatal skin, DIO3 exhibited a high degree of monoallelic expression from the paternal allele.

4. Presence and subcellular location of D3 in human neutrophils for the first time and propose a model, in which D3 plays a role in the bacterial killing capacity of neutrophils either through generation of iodide for the myeloperoxidase (显示 MPO 抗体) system or through modulation of intracellular Thyroid hormone (显示 PTH 抗体) bioavailability.

5. MAPK (显示 MAPK1 抗体) and SHH (显示 SHH 抗体) pathways modulate type 3 deiodinase expression in papillary thyroid carcinoma

6. Thyroid hormone (显示 PTH 抗体) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (显示 PTH 抗体) exposure.

7. the microRNA cluster at the Dlk1 (显示 DLK1 抗体)-Dio3 locus is upregulated in lung adenocarcinoma

8. [review] D3 polymorphisms show no relationship with inter-individual variation in serum thyroid hormone (显示 PTH 抗体) parameters.

9. Overall, the data suggest that active expression of the DLK1 (显示 DLK1 抗体)-DIO3 cluster represents a new biomarker for epigenetic stability of hESCs and indicates the importance of using a proper physiological oxygen level during the derivation and culture of hESCs.

10. the imprinted DLK1 (显示 DLK1 抗体)-DIO3 locus is regulated by noncoding RNA IPW in an induced pluripotent stem cell model of Prader-Willi syndrome

Pig (Porcine) Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

1. The imprinted gene DIO3 is a candidate gene for litter size in pigs

2. DIO3 gene polymorphism was significantly associated with almost all fat deposition and carcass traits.

Cow (Bovine) Deiodinase, Iodothyronine, Type III (DIO3) interaction partners

1. An allele-specific expression analysis-based SNP method revealed that DIO3 and DIO3OS genes exhibited monoallelic expression in the eight tissues, indicating that DIO3 and DIO3OS are imprinted in cattle.