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The expression of DIO1 (显示 DIDO1 蛋白) on mRNA/protein levels in the depressive disorder patients was reduced in comparison to the control subjects.
wW observed that the DIO1 (显示 DIDO1 蛋白) rs2235544 SNP modified the association between exposure to some of the organochlorine compounds (OCs) (specifically HCB and PCB153) and maternal thyroid hormone (显示 PTH 蛋白) levels. These results strengthen the hypothesis that the deiodinase enzymes play a role in explaining the disruption of thyroid hormones in relation to exposure to OCs.
data supports the notion that suppressed DIO1 (显示 DIDO1 蛋白) expression and changes in local availability of thyroid hormones might favor a shift from a differentiated to a more proliferation-prone state of cancer tissues and cell lines
results indicated that LXRalpha (显示 NR1H3 蛋白) plays a specific and important role in activation of TH by regulating D1, and that LXRalpha (显示 NR1H3 蛋白) binds to and regulates the hDIO1 promoter, competing with TRbeta (显示 TXNRD2 蛋白) on specific sequences within the promoter.
The DIO1 (显示 DIDO1 蛋白) gene is related to the depression.
Functional variants within the DIO1 (显示 DIDO1 蛋白) gene that affect triiodothyronine (T3) levels seem not to be associated with cognitive functions.
All these results indicate that the oxidative stress downregulates the conversion of T4 to T3 through DIO1 (显示 DIDO1 蛋白) function in HepG2 cells.
Thyroid hormone (显示 PTH 蛋白) deiodinases D1, D2, and D3 are differentially expressed in endothelial cells following thyroid hormone (显示 PTH 蛋白) exposure.
The pattern of expression and role of triiodothyronine (T3) receptors and type I 5'-deiodinase in breast carcinomas, benign breast diseases, lactational change, and normal breast epithelium.
[review] Deiodinase type 1 polymorphisms particularly show moderate-to-strong relationships with thyroid hormone (显示 PTH 蛋白) parameters, insulin (显示 INS 蛋白)-like growth factor (IGF)1 (显示 IGF1 蛋白) protein production, and risk for depression.
Reductions in Dio1 expression reduce the expression of ApoA-I (显示 APOA1 蛋白) in a 3,5,3'-triiodothyronine-/thyroid hormone (显示 PTH 蛋白) response element-independent manner.
Systemic changes in thyroid hormone (显示 PTH 蛋白) economy as a result of acute food deprivation are not dependent on the deiodinases D1 or D2 but are mediated in part by sequestration of type4 and type3 in tissues and their enhanced metabolism by deiodinase D3.
Results demonstrate changes in D1 activity in white adipose tissue under conditions of changing adiposity, and a stimulatory effect of leptin (显示 LEP 蛋白) on D1 activity in the tissue.
A decreased hepatic D1 activity could be the biochemical basis of some of the abnormal thyroid parameters observed in cystic fibrosis (显示 S100A8 蛋白)
The type 1 deiodinase (D1) is an important source of Triiodothyronine in the euthyroid state.
HNF4alpha (显示 HNF4A 蛋白) regulates thyroid hormone (显示 PTH 蛋白) homeostasis through transcriptional regulation of the Dio1 gene with GATA4 (显示 GATA4 蛋白) and KLF9 (显示 KLF9 蛋白)
This study investigated deiodinase 1 (Dio1), deiodinase 2 (Dio2 (显示 DIO2 蛋白)), and deiodinase 3 (Dio3 (显示 DIO3 蛋白)) mRNA expression at the several zebrafish life stages and found life stage specific expression of these genes that were highly localized.
The protein encoded by this gene is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD). Alternative splicing results in multiple transcript variants encoding different isoforms. Some, but not all, isoforms contain a selenocysteine (Sec) residue encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Additional transcript variants have been described but are not supported by experimental evidence.
, thyroxine deiodinase type I (selenoprotein)
, type 1 DI
, type I iodothyronine deiodinase
, type-I 5'-deiodinase
, thyroxine deiodinase, type I
, thyroxine deiodinase type 1
, Type 1 DI
, Type-I 5'-deiodinase
, deiodinase, iodothyronine, type I
, type 1 deiodinase