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The plasma ADM2 levels were inversely correlated with obesity in humans, and adipo-ADM2-transgenic (tg) mice displayed resista (显示 MAPK14 蛋白)nce to high-fat diet-induced obesity with increased energy expenditure.
Mouse and human heart valves expressed mRNAs for the CRL (显示 IL31RA 蛋白) ligands adrenomedullin (显示 ADM 蛋白) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (显示 CALCA 蛋白)) and for their receptor components, i.e., CRL (显示 IL31RA 蛋白) and receptor-activity-modifying proteins 1-3.
ADM-2 is a stress-inducible gene controlled by ATF-4 (显示 ATF4 蛋白).
Intermedin1-53 may attenuate vascular calcification by upregulating alpha-Klotho (显示 KL 蛋白) via the calcitonin receptor (显示 CALCR 蛋白)/modifying protein complex and protein kinase A signaling.
Intermedin (IMD) derived from human cardiac microvascular endothelial cell and acting in a paracrine manner on cardiomyocytes, predominantly at AM1 receptors, is more likely to contribute to direct protection by endogenous IMD of cardiomyocytes against acute ischemia reperfusion injury.
Elevated plasma intermedin levels are independently associated with long-term recurrence and distant metastasis of prostate cancer.
ADM2 may contribute to the physiology of embryo implantation and placental growth via increasing MMP2 (显示 MMP2 蛋白) and decreasing MUC1 (显示 MUC1 蛋白) expression to facilitate trophoblast invasion.
Plasma intermedin and BNP levels were markedly higher in acute coronary syndrome patients than in healthy people.
High levels of ADM2 expression predict a poorer survival in patients with pancreatic adenocarcinoma.
TSH induced AM2/IMD expression in the thyroid gland and it could locally work as a potent vasodilator, resulting in the expansion of thyroid inter-follicular capillaries.
Intermedin attenuated neointima formation in the mouse model of common carotid-artery ligation injury. IMD protection may be mediated by maintaining a vascular smooth muscle cell contractile phenotype via the cAMP/PKA pathway.
results indicate that endogenous AM2 might be involved in energy metabolism in adipocytes through the upregulation of UCP1 (显示 UCP1 蛋白) expression
ADM2 enhances subcutaneous White Adipose Tissue beiging via a direct effect by activating the CRLR.RAMP1-cAMP/PKA and p38 MAPK (显示 MAPK14 蛋白) pathways in white adipocytes and via an indirect effect by stimulating alternative M2 polarization in macrophages.
Mouse and human heart valves expressed mRNAs for the CRL ligands adrenomedullin (显示 ADM 蛋白) (AM), adrenomedullin-2 (AM-2) and calcitonin gene-related peptide (CGRP (显示 CALCA 蛋白)) and for their receptor components, i.e., CRL and receptor-activity-modifying proteins 1-3.
IMD reduces bone resorption by inhibiting osteoblast apoptosis, decreasing the RANKL/OPG (显示 TNFSF11 蛋白) ratio and the expression of M-CSF (显示 CSF1R 蛋白), and inhibiting osteoclast maturation and differentiation.
Adrenomedullin-2/intermedin(8-47) ameliorates early ischemia/reperfusion injury in mouse lungs by protecting the integrity of the blood-air barrier and by potently reducing leukocyte influx into the alveolar space
Intermedin attenuates macrophage foam-cell formation via tristetraprolin (显示 ZFP36 蛋白)-mediated degradation of CD36 (显示 CD36 蛋白) mRNA.
increased stability of PTEN by intermedin leads to SR-A (显示 MSR1 蛋白) inhibition in macrophages, which ameliorates foam-cell formation and atherosclerosis in apoE (显示 APOE 蛋白)(-/-) mice.
Data show that mechanical ventilation reduced the expression of receptor activity-modifying protein RAMP3 (显示 RAMP3 蛋白), but not of intermedin (IMD), calcitonin receptor-like receptor (CRLR (显示 CALCRL 蛋白)), and RAMP1 (显示 RAMP1 蛋白) and RAMP2 (显示 RAMP2 蛋白).
Intermedin is a calcitonin/calcitonin (显示 CALCA 蛋白) gene-related peptide (显示 CALCA 蛋白) family peptide acting through the calcitonin receptor-like receptor (显示 CALCRL 蛋白)/receptor activity-modifying protein receptor complexes
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, adrenomedullin 2 precusor