HNRNPA1 产品
(Heterogeneous Nuclear Ribonucleoprotein A1 (HNRNPA1))
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This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It is one of the most abundant core proteins of hnRNP complexes and it is localized to the nucleoplasm. This protein, along with other hnRNP proteins, is exported from the nucleus, probably bound to mRNA, and is immediately re-imported. Its M9 domain acts as both a nuclear localization and nuclear export signal. The encoded protein is involved in the packaging of pre-mRNA into hnRNP particles, transport of poly A+ mRNA from the nucleus to the cytoplasm, and may modulate splice site selection. It is also thought have a primary role in the formation of specific myometrial protein species in parturition. Multiple alternatively spliced transcript variants have been found for this gene but only two transcripts are fully described. These variants have multiple alternative transcription initiation sites and multiple polyA sites. [provided by RefSeq, Jul 2008].
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Featured HNRNPA1 Categories
HNRNPA1 抗体
High quality antibodies with extensive validation data.
HNRNPA1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
HNRNPA1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HNRNPA1 抗体
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Recommended HNRNPA1 ELISA试剂盒
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Chicken
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Latest Publications for our HNRNPA1 Products
: "FUS pathology in ALS is linked to alterations in multiple ALS-associated proteins and rescued by drugs stimulating autophagy. ..." in: Acta neuropathologica, Vol. 138, Issue 1, pp. 67-84, (2019) (PubMed).: "Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD." in: Neuron, Vol. 103, Issue 5, pp. 802-819.e11, (2019) (PubMed).
: "Identification of the TXNIP IRES and characterization of the impact of regulatory IRES trans-acting factors." in: Biochimica et biophysica acta. Gene regulatory mechanisms, Vol. 1861, Issue 2, pp. 147-157, (2018) (PubMed).
: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." in: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).
: "The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization." in: Molecular biology of the cell, pp. mbcE18020108, (2018) (PubMed).
: "SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling." in: Cell research, Vol. 27, Issue 4, pp. 540-558, (2017) (PubMed).
: "sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism." in: Biochimica et biophysica acta, Vol. 1859, Issue 7, pp. 848-59, (2016) (PubMed).
: "Proteomic analysis of FUS interacting proteins provides insights into FUS function and its role in ALS." in: Biochimica et biophysica acta, Vol. 1862, Issue 10, pp. 2004-14, (2016) (PubMed).
: "AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors." in: Nature communications, Vol. 7, pp. 13347, (2016) (PubMed).
: "Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells." in: Oncogene, Vol. 35, Issue 30, pp. 3897-908, (2016) (PubMed).
Synonyms and alternative names related to HNRNPA1
heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1), heterogeneous nuclear ribonucleoprotein A1b (hnrnpa1b), heterogeneous nuclear ribonucleoprotein A1 (LOC100101226), Heterogeneous nuclear ribonucleoprotein A1 (roa1), heterogeneous nuclear ribonucleoprotein A1 (Hnrnpa1), heterogeneous nuclear ribonucleoprotein A1 S homeolog (hnrnpa1.S), ribonucleoprotein A1a (hnrnpa1), heterogeneous nuclear ribonucleoprotein A1 (hnrnpa1), heterogeneous nuclear ribonucleoprotein A1-like (LOC100359118), heterogeneous nuclear ribonucleoprotein A1a (hnrnpa1a), D15Ertd119e, Hdp, hnRNP-A1, hnrnp-A1, hnRNP A1, HNRNPA1, HNRPA1, hnrpa1, Hnrpa1, HNRPA1L3, ROA1, TPT1P, zgc:66127Protein level used designations for HNRNPA1
- Putative heterogeneous nuclear ribonucleoprotein A1-like 3
- helix-destabilizing protein
- heterogeneous nuclear ribonucleoprotein A1B protein
- heterogeneous nuclear ribonucleoprotein B2 protein
- heterogeneous nuclear ribonucleoprotein core protein A1
- hnRNP A1-like 3
- hnRNP core protein A1
- hnRNP core protein A1-like 3
- nuclear ribonucleoprotein particle A1 protein
- single-strand DNA-binding protein UP1
- single-strand RNA-binding protein
- hnRNP A1-gamma isoform
- single-strand-binding protein
- heterogeneous nuclear ribonucleoprotein A1
- hormonally upregulated Neu-associated kinase
- Heterogeneous nuclear ribonucleoprotein A1
- HDP-1
- helix destabilizing protein
- topoisomerase-inhibitor suppressed
- HDP
- heterogeneous ribonuclear particle protein
- hnRNP A1
- heterogeneous nuclear ribonucleoproteins A1 homolog
- UP1
- unwinding protein 1
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