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Histocompatibility 2, Class II Antigen E Alpha, Pseudogene 蛋白

(Histocompatibility 2, Class II Antigen E Alpha, Pseudogene (H2-EA-PS))
This locus belongs to the class II major histocompatibility complex (MHC) family of genes, which encode immune response (Ia) antigens that function in the T-cell-dependent immune response. This family member has multiple haplotypes, some of which result in the production of an E-alpha subunit that combines with an E-beta subunit to form a functional E complex at the cell surface. Other haplotypes, including that of the reference genome allele, contain mutations and they thus represent polymorphic pseudogenes that do not produce functional products. These mutations include frameshifting indels, nonsense mutations, and deletions of larger regions. The reference genome haplotype contains a deletion at the 5' end of the gene, including the core promoter region and the transcription start site, and therefore no transcripts result from this haplotype.

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Synonyms and alternative names related to Histocompatibility 2, Class II Antigen E Alpha, Pseudogene

histocompatibility 2, class II antigen E alpha, pseudogene (H2-Ea-ps), AI323765, E-alpha-f, H-2Ea, H2-Ea, I-Ealpha, Ia-3, Ia3

Protein level used designations for Histocompatibility 2, Class II Antigen E Alpha, Pseudogene

  • H-2 class II histocompatibility antigen, E-D alpha chain
  • H-2 class II histocompatibility antigen, E-K alpha chain
  • H-2 class II histocompatibility antigen, E-U alpha chain
  • H2-IE-alpha
  • I-E alpha MHC class II
  • MHC class II antigen E alpha
  • MHC class II protein
  • histocompatibility 2, class II antigen E alpha
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