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TXK ELISA试剂盒

(TXK tyrosine Kinase (TXK))
Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T- cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskekleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell- specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr- 201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.
TXK ELISA 试剂盒 TXK ELISA 试剂盒 TXK ELISA 试剂盒 (ABIN6971009)

TXK 适用: 人 Colorimetric Sandwich ELISA 0.313 ng/mL - 20 ng/mL Plasma, Serum, Tissue Homogenate

TXK ELISA 试剂盒 (ABIN4886333)

TXK 适用: 人 pTyr Colorimetric Sandwich ELISA Cell Lysate, Tissue Lysate

TXK ELISA试剂盒 by 适用

Find TXK ELISA试剂盒 for a variety of species such as anti-Human TXK. The species listed below are among those available. Click on a link to go to the corresponding products.

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TXK ELISA试剂盒 by Analytical Method

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TXK ELISA试剂盒 by 样本

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TXK ELISA试剂盒 by 抗原表位

Find TXK ELISA试剂盒 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

Popular TXK ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6971009
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886333
Quantity 96 tests
Datasheet Datasheet

Aliases for TXK ELISA试剂盒

TXK tyrosine kinase (TXK) ELISA试剂盒
TXK tyrosine kinase (Txk) ELISA试剂盒
tyrosine-protein kinase TXK (LOC100544958) ELISA试剂盒
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Btkl ELISA试剂盒
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TKL ELISA试剂盒
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