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抗Human SUFUH 抗体:
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Human Polyclonal SUFUH Primary Antibody for WB - ABIN871409
Zimmern, Kobashi, Lemack: Outcome measure for stress urinary incontinence treatment (OMIT): results of two society of urodynamics and female urology (SUFU) surveys. in Neurourology and urodynamics 2010
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Human Polyclonal SUFUH Primary Antibody for WB - ABIN6244108
Wang, Li, Hu, Huang, Rao, Xiong, Luo, Lu, Luo: Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism. in Cellular signalling 2017
A Comparison of Ci/Gli (显示 GLI1 抗体) Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog (显示 SHH 抗体) Response
Sufu can sequester Ci/Gli (显示 GLI1 抗体) in the cytoplasm through binding to an N-terminal site while inhibiting Ci/Gli (显示 GLI1 抗体) activity in the nucleus depending on a C-terminal Sufu-interacting site.
Drosophila Hedgehog (显示 SHH 抗体) signaling promotes downregulation of Su(fu) through its target protein HIB (Hh-induced BTB protein).
Suppressor of fused (Sufu) opposes Trn-mediated Ci nuclear import by masking its PY-nuclear localization sequence.
The 'closed' form of Sufu is stabilized by Gli (显示 GLI1 抗体) binding and inhibited by Hh treatment, whereas the 'open' state of Sufu is promoted by Gli (显示 GLI1 抗体)-dissociation and Hh signaling.
Su(fu) causes the Rdx (显示 RDX 抗体) switch between two mchanisms of Cubitus interruptus regulation.
Suppressor of Fused represses Gli (显示 GLI1 抗体)-mediated transcription by recruiting the SAP18 (显示 SAP18 抗体)-mSin3 corepressor complex.
Differential Hh target gene regulation can be accomplished by differential sensitivity of Cos2 (显示 KIF7 抗体) and Su(Fu) to Hh.
Su(fu) protein levels and isoforms are crucial for the modulation of the different Ci states that control Hh target gene expression.
Sufu may act as a common regulator of Hh and Wnt (显示 WNT2 抗体) signaling and contribute to intertwining the two pathways.
Down-regulation of microRNA-224 inhibits growth and epithelial-to-mesenchymal transition phenotype via modulating SUFU expression in bladder cancer cells.
Itch/beta-arre (显示 ARRB2 抗体)stin2 complex binds SuFu and induces its Lys63-linked polyubiquitylation without affecting its stability.
Patients with SUFU pathogenic variants were significantly more likely to develop a medulloblastoma, a meningioma or an ovarian fibroma, but were less likely to develop a jaw cyst.
Nek2A (显示 NEK2 抗体) is found to stabilize SuFu at least partly depending on its kinase activity, thereby triggering phosphorylation of the SuFu protein.
Extra-mitochondrial prosurvival BCL-2 (显示 BCL2 抗体) proteins regulate gene transcription by inhibiting the SUFU tumour suppressor.
Missense mutation in SUFU gene is associated with Joubert Syndrome with Cranio-facial and Skeletal Defects.
In conclusion, this study showed the potential of miR (显示 MLXIP 抗体)-342-3p as a therapeutic target to promote bone regeneration by modulating expression of Sufu in UCMSCs.
miRNA-194 is oncogenic and promotes gastric cancer cell proliferation and migration by activating Wnt (显示 WNT2 抗体) signaling, at least in part, via suppression of SUFU.
SUFU's role in Hedgehog (显示 SHH 抗体) signaling, tumor progression, and highlight a way in which BCCs can arise
In summary, these findings reveal Fbxl17 (显示 FBXL17 抗体) as a novel regulator of the Hedgehog (显示 SHH 抗体) signaling pathway and highlight the perturbation of the Fbxl17 (显示 FBXL17 抗体)-Sufu axis in the pathogenesis of medulloblastoma.
Through regulation of su(fu), miR (显示 MYLIP 抗体)-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog (显示 SHH 抗体).
Together, our results show that SuFu promotes cerebellar radial precursor differentiation to neurons. SuFu function is mediated in part by GLI3R and down-regulation of Fgf15 expression.
beta-Arrestin2 (显示 ARRB2 抗体) increases the Itch-mediated ubiquitylation of SuFu.
tissue development is differentially affected in response to the reduced SUFU levels.
Suppressor of Fused restraint of Hedgehog (显示 SHH 抗体) activity level is critical for osteogenic proliferation and differentiation during calvarial bone development
Sufu is upregulated in active Shh (显示 SHH 抗体) responding tissues and accompanies Gli (显示 GLI1 抗体) activators translocating into and Gli (显示 GLI1 抗体) repressors out of the nucleus.
Sufu deletion early in embryogenesis resulted in unstable Gli2 (显示 GLI2 抗体) and Gli3 (显示 GLI3 抗体) activity, leading to the ectopic activation of Shh (显示 SHH 抗体) signaling.
Thus, we provide evidence that Sufu is involved in the genetic network that restricts the posterior expression of Gli2 (显示 GLI2 抗体)/3/Hand2 (显示 HAND2 抗体) and Gremlin (显示 GREM1 抗体)/Fgf in limb bud patterning.
Results showed that the Thr396 residue of Sufu is specifically required for regulation of Gli3 (显示 GLI3 抗体) but not Gli2 (显示 GLI2 抗体) implying a novel Sufu-mediated mechanism in which Gli2 (显示 GLI2 抗体) activator and Gli3 (显示 GLI3 抗体) repressor are differentially regulated.
findings demonstrate that perturbations of Sufu and Kif7 (显示 KIF7 抗体) affect Gli (显示 GLI1 抗体) activity and recapitulate the full spectrum of vertebrate limb defects, ranging from severe truncation to polydactyly.
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
, suppressor of fused
, suppressor of fused homolog