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Human LTBP2 Protein expressed in Escherichia coli (E. coli) - ABIN2125613
Inamoto, Martin, Paczesny, Tabellini, Momin, Mumaw, Flowers, Lee, Carpenter, Storer, Hanash, Hansen: Association of Plasma CD163 Concentration with De Novo-Onset Chronic Graft-versus-Host Disease. in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2017
effects of both oxidative stress and LTBP2 knockdown on the extracellular matrix and apoptosis may be mediated by TGFbeta and BMP signaling pathway activation
LTBP2 is a novel biomarker for the diagnosis of pancreatic cancer.
Our data suggest that LTBP2 acts as an oncogene (显示 RAB1A 蛋白) in head and neck squamous cell carcinoma development and progression
knockdown of LTBP2 inhibits invasion and tumorigenesis in thyroid carcinoma cells.
We identified one nonsense mutation (c.2421G>A, p.W807X) in LTBP2 in eight Indian families. Among the mutations identified W807X in LTBP2 represent novel mutations.
LTBP-1 (显示 LTBP1 蛋白) and LTBP-2 are involved in the keratinization of oral epithelium.
The results showed that no deleterious mutations were found in coding regions of LTBP2 in patients with PCG, suggesting that it is not a causal gene for primary congenital glaucoma in the Han Chinese population.
LTBP-2 and FGF-2 (显示 FGF2 蛋白) are co-localized in fibrotic human keloid and hypertrophic scar.
LTBP-2 is a potent inhibitor of FGF-2 (显示 FGF2 蛋白) that may influence FGF-2 (显示 FGF2 蛋白) bioactivity during wound repair particularly in fibrotic tissues.
LTBP2 was able to reduce phosphorylation of p65 (显示 GORASP1 蛋白) at Serine 536, inhibit nuclear localization of active phosphorylated p65 (显示 GORASP1 蛋白), and impair the p65 (显示 GORASP1 蛋白) DNA-binding ability. This results in a consequential down-regulation of p65 (显示 GORASP1 蛋白)-related gene expression.
LTBP-2 is an essential component for the formation of microfibril bundles in ciliary zonules.
perlecan (显示 HSPG2 蛋白) HS was not essential for latent transforming growth factor-beta-1 (显示 TGFB1 蛋白) binding protein-2 deposition
Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5 (显示 PCSK5 蛋白)/6A.
These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta (显示 TGFB1 蛋白) binding proteins affecting TGFbeta (显示 TGFB1 蛋白) bioavailability in the ovary.
The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion.
, latent-transforming growth factor beta-binding protein 2
, LTBP-2 like protein
, latent transforming growth factor beta binding protein 3
, latent transforming growth factor beta binding protein 2
, latent-transforming growth factor beta-binding protein 2-like