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Cleavage of the Interleukin-11 receptor (显示 IL11RA 蛋白) induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
In spite of clear changes in the temporal expression of both IL-11 (显示 IL11 蛋白) and its receptor, no significant differences in motor function are found after spinal cord injury.
Signaling through the IL-35 receptor required the transcription factors STAT1 (显示 STAT1 蛋白) and STAT4 (显示 STAT4 蛋白).
Demyelination and oligodendrocyte death are exacerbated in IL-11 receptor alpha (显示 IL11RA 蛋白)-deficient mice, suggesting avenues to enhance oligodendrocyte viability and restrict central nervous system inflammation in multiple sclerosis.
This study underlines the importance of gp130 cytokines in proliferation and establishes its role in auto-paracrine pituitary growth regulation.
IL-13-induced lung inflammation, remodeling, respiratory failure and death are all diminished in mice deficient in the IL-11 receptor alpha-gp130 complex.
IL-11 (显示 IL11 蛋白) signaling is clearly required for normal bone turnover and normal trabecular bone mass, yet not for the effects of estradiol or estrogen deficiency on the skeleton.
These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua.
A soluble form (sIL11RA) can act as an antagonist of IL11-dependent cell differentiation in cells where both transmembrane IL11RA and IL6ST are present. Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth.
IL-11 receptor subunit alpha-1
, IL-11R subunit alpha-1
, enhancer trap locus homolog 2
, interleukin 11 receptor, alpha chain 2
, interleukin-11 receptor subunit alpha-1
, locus 2
, novel cytokine receptor 1
, IL-11 receptor subunit alpha
, IL-11R subunit alpha
, interleukin-11 receptor alpha chain
, interleukin-11 receptor subunit alpha