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Human HTRA1 Protein expressed in Escherichia coli (E. coli) - ABIN368668
Frochaux, Hildebrand, Talke, Linscheid, Schlüter: Alpha-1-antitrypsin: a novel human high temperature requirement protease A1 (HTRA1) substrate in human placental tissue. in PLoS ONE 2014
HtrA1 is indispensable for dorsoventral patterning in early zebrafish embryogenesis and serves as a key upstream regulator of FGF signaling through the control of FGF levels.
Our data point to a yet unexpected effect of decreased HTRA1 expression on drusen pathogenesis. Thus not only a higher HTRA1 expression, but an imbalance of HTRA1 might be disease-relevant.
Tests for association revealed a variant in the promoter region of HTRA1 and two variants in the 5'-UTR of ARMS2 (显示 ARMS2 蛋白) to be associated with drusen.
As in humans, one variant within LOC387715/ARMS2 (显示 ARMS2 蛋白) and one in HTRA1 were significantly associated with age-related macular degeneration.
These data implicate HTRA1 as a negative regulator of mesenchymal stem cell adipogenesis.
These results suggest that the initiation stage of polypoidal choroidal vasculopathy is mediated by proteolytic degradation of extracellular matrix proteins attributable to increased HTRA1 activity
The findings of the present study provide evidence that CFH (显示 CFH 蛋白) gene variants and ARMS2 (显示 ARMS2 蛋白)/HTRA1 genes play a major role in the genetic susceptibility to AMD (显示 AMD1 蛋白) in a Greek population. These findings are of direct relevance for disease and help mapping the genetic chart of AMD (显示 AMD1 蛋白).
The function of the binding between MIF (显示 AMH 蛋白) and HTRA1 is to inhibit the proteolytic activity of HTRA1.
Results show that HTRA1 is epigenetically silenced in HCT116 colon carcinoma cells and during early stages of tumorigenesis in a mouse model of intestinal cancer. Downregulation of HTRA1 causes a multiple phenotypes that are hallmarks of cancer cells including increased proliferation of mouse embryonic fibroblasts, as well as chromosome and centrosome amplifications.
High HTRA1 expression is associated with cervical cell proliferation.
Data indicate HtrA serine peptidase 1 (HTRA1) involvement in Age-related macular degeneration (AMD (显示 AMD1 蛋白)) pathogenesis.
Variants in HTRA1 are not associated with age-related macular degeneration.
Results show the heterozygous missense mutations p.G283E, p.P285L, p.R302Q, and p.T319I in the HTRA1 gene in 8 patients with symptomatic cerebral small vessel disease; mutant HTRA1s observed in manifesting heterozygotes might result in an impaired HTRA1 activation cascade of HTRA1 or be unable to form stable trimers
FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation
transfection of cells with a constitutively active rapamycin-resistant p70S6K (显示 RPS6KB1 蛋白) mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells.
Increased expressions of Tgf-beta1 (显示 TGFB1 蛋白), p-Smad2 (显示 SMAD2 蛋白)/3 and HtrA1 were detected in the articular chondrocytes of knee joints in models of osteoarthritis.
In mouse brain tissue and embryonic fibroblasts there is a facilitating role of HtrA1 in TGF-beta (显示 TGFB1 蛋白) pathway activation.
HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone
The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD (显示 AMD1 蛋白)
the inhibitory effect of IFN-gamma (显示 IFNG 蛋白) on HTRA1 expression was evidenced in collagen-induced arthritis (CIA (显示 NCOA5 蛋白)) mouse models and in human RA synovial cells.
Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation.
Data show that HtrA1 is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (显示 BMP2 蛋白)-induced Smad1 (显示 SMAD1 蛋白)/5/8, ERK1/2 and p38 (显示 CRK 蛋白) phosphorylation in pre-osteoblasts.
This study offers new insights into the regulation of HTRA-1 expression via LPS (显示 TLR4 蛋白)/TLR-4 (显示 TLR4 蛋白) and the role of HTRA-1 in rheumatoid arthrisis pathogenesis.
suggest a critical role for LRP1 (显示 LRP1 蛋白) in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor (显示 CTGF 蛋白) protein levels.
The results are consistent with a mechanism by which xHtrA1, through cleaving proteoglycans, releases cell-surface-bound Fibroblast Growth Factors (FGF) ligands and stimulates long-range FGF signaling.
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
HtrA serine peptidase 1
, high-temperature requirement A serine peptidase 1A
, serine protease 11
, serine protease HTRA1A
, high-temperature requirement A serine peptidase 1B
, serine protease HTRA1B
, high temperature required A1
, Serine protease HTRA1
, high-temperature requirement A serine peptidase 1
, protease, serine, 11 (IGF binding)
, serine protease HTRA1
, insulin-like growth factor binding protein 5 protease
, protease, serine, 11 (Igf binding)
, IGF binding
, protease, serine, 11
, protease serine 11
, High-temperature requirement A serine peptidase 1
, Serine protease 11