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OGN identified as a novel oncogene (显示 RAB1A 蛋白) in meningioma proliferation.
serum osteoglycin is a potential predictor of adverse outcomes in patients with chronic kidney disease.
NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin (显示 PTN 蛋白) and osteoglycin.
Increased serum mimecan is associated with poor angiographic coronary collateralization in patients with chronic total occlusion
the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD (显示 BEST1 蛋白)), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported.
OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF (显示 VEGFA 蛋白)-VEGFR2 (显示 KDR 蛋白) signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4 (显示 TLR4 蛋白).
mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin (显示 LEP 蛋白) signaling by inducing IL-1beta (显示 IL1B 蛋白) and IL-6 (显示 IL6 蛋白) expression in the hypothalamus.
Increased plasma mimecan levels are independently associated with increased arterial stiffness in hypertensive patients.
OIF may be an indicator of the earlier-stage diabetic nephropathy in subjects with type 2 diabetes mellitus
These results reveal a novel pathway in which miR (显示 MLXIP 蛋白)-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells.
elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase (显示 MAPK1 蛋白)/activator protein 1 (显示 JUN 蛋白) pathway (MAPK (显示 MAPK1 蛋白)/AP-1 (显示 JUN 蛋白)).
lack of the proteoglycan (显示 Vcan 蛋白) OGN does not affect the progression of atherosclerosis in mice
The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice.
Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues.
The temporal-spatial specific pattern and unique co-localization of Dspp (显示 DSPP 蛋白), Mepe, Mimecan and Versican (显示 Vcan 蛋白) suggest they play complementary roles during odontogenesis.
From our study we conclude that downregulation of osteoglycin is a fundamental requirement for proper arteriogenesis
Mapping of the OGN and ASPN (显示 ASPN 蛋白) genes and association with growth and carcass traits.
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene.
corneal keratan sulfate proteoglycan
, mimecan proteoglycan
, osteoinductive factor
, osteoglycin (osteoinductive factor)
, osteoglycin (osteoinductive factor, mimecan)
, osteoglycin preproprotein