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OGN expression is positively associated with CD8+ cell density in colorectal cancer tissue, suggesting a possible influence of OGN expression on tumor reactive T cells in the tumor niche.
Results provide evidence that osteoglycin expression is increased in the heart in response to pressure overload and its absence results in increased cardiac inflammation and fibrosis resulting in increased diastolic dysfunction.
OGN identified as a novel oncogene in meningioma proliferation.
serum osteoglycin is a potential predictor of adverse outcomes in patients with chronic kidney disease.
NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin.
Increased serum mimecan is associated with poor angiographic coronary collateralization in patients with chronic total occlusion
the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported.
OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration.
The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4.
mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus.
Increased plasma mimecan levels are independently associated with increased arterial stiffness in hypertensive patients.
OIF may be an indicator of the earlier-stage diabetic nephropathy in subjects with type 2 diabetes mellitus
OGN might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC.
Osteomodulin, osteoglycin, and asporin appear to be distinctly regulated in osteoarthritis labrum compared to OA cartilage.
The lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice. Possible causes for the absence of phenotype in the Apoe/Ogn double mutants are discussed.
Circulating OGN and NGAL/MMP9 complex are promising biomarkers that are expressed in vulnerable atherosclerotic plaques and may have incremental value for prediction of MACE within 1 year after coronary angiography.
We found that IGF-2 and IGFBP2 synergistically increased neurite outgrowth via enhanced early signaling through the IGF type 1 receptor.
This work provides insight into the regulating mechanism of mimecan in pituitary and suggests that mimecan may be an unidentified pituitary secretory protein, and certain pituitary cells secreting ACTH or GH also secrete mimecan.
All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01).
High expression in the cochlea may be suggestive of a fundamental role for a transcript in the auditory system
These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells.
elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1).
lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice
The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice.
Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues.
The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis.
even though there are 3-5 glucocorticoid response elements in the mimecan promoter, glucocorticoid may regulate mimecan transcription indirectly through the synthesis of intermediate proteins
Mimecan in pituitary corticotroph cells may regulate adrenocorticotrophic hormone secretion and the hypothalamo-pituitary-adrenal axis
High expression of osteoglycin decreases the gelatinase activity of hepatocarcinoma Hca-F cells cultured with extract of lymph node.
processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils
Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds
In summary, high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes.
From our study we conclude that downregulation of osteoglycin is a fundamental requirement for proper arteriogenesis
Mapping of the OGN and ASPN genes and association with growth and carcass traits.
This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). Alternatively spliced transcript variants that encode the same protein have been found for this gene.
corneal keratan sulfate proteoglycan
, mimecan proteoglycan
, osteoinductive factor
, osteoglycin (osteoinductive factor)
, osteoglycin (osteoinductive factor, mimecan)
, osteoglycin preproprotein