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抗Rat (Rattus) Neurocan 抗体:
抗Human Neurocan 抗体:
抗Mouse (Murine) Neurocan 抗体:
Human Polyclonal Neurocan Primary Antibody for IF (p), IHC (p) - ABIN737001
Yang, Fang, Wang, Chen, Shen: Transplantation of Schwann cells differentiated from adipose-derived stem cells modifies reactive gliosis after contusion brain injury in rats. in The Journal of international medical research 2011
Human Polyclonal Neurocan Primary Antibody for IHC (p), WB - ABIN5519042
Wang, Zhang, Zhang, Fan, Shen, Hu, Chen: Oxygen-glucose deprivation induced glial scar-like change in astrocytes. in PLoS ONE 2012
NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found.
This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups.
NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation
current data demonstrate that common genetic variation in NCAN influences both neural processing and cognitive performance in healthy subjects.
The frequency of the NCAN rs2228603 T allele was significantly increased in patients with HCC due to ALD (15.1%) compared to alcoholic cirrhosis without HCC (9.3%), alcoholic controls (7.2%), healthy controls (7.9%), and HCV associated HCC (9.1%).
NCAN risk variant is associated with cortical folding and thickness in bipolar disorder and schizophrenia.
Conditional analysis shows that a neighbouring gene, TM6SF2, not NCAN, is responsible for the Chr 19 GWAS locus previously associated with fibrosing non-alcoholic fatty liver disease (NAFLD).
NCAN rs2228603[T] is a risk factor for liver inflammation and fibrosis, suggesting that this locus is responsible for progression from steatosis to steatohepatitis.
no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia.
In the combined patient sample, the NCAN risk allele was significantly associated with the "mania" factor, in particular the subdimension "overactivity.
The rs1064395 A-allele was significantly over-represented in schizophrenia patients compared to controls. Our data suggest that genetic variation in NCAN is a common risk factor for bipolar disorder and schizophrenia.
High neurocan is associated with the invasive phenotype of low-grade astrocytoma.
Sex (male)-specific association of rs16996148 SNP in the NCAN/CILP2/PBX4 and serum lipid levels is observed both the Mulao and Han ethnic groups.
Genetic variation in the neurocan gene (NCAN) showed genome-wide significant association with bipolar disorder.
The synaptic plasticity occurs in the hippocampus of freely behaving mice that lack neurocan, the informational content stored by synaptic plasticity is not the same.
Study shows the viability and proliferation of astrocytes are significantly increased by beta-amyloid in a dose dependent manner. Moreover, beta-amyloid may effectively up-regulate the neurocan expression via regulating Sox9.
This study provided evidence that the neurocan modulates synaptogenesis and long-term synapse stability. The mutant neurons display reduced frequencies of mEPSCs and mIPSCs.
Traumatic brain injury results in an increase in the chondroitin glycosaminoglycans (CSPGs) neurocan and NG2 expression in a tight band surrounding the injury core.
Ncan -/- mice showed behavioral abnormalities that were strikingly similar to those of the human mania phenotype.
neurocan contributes to the molecular heterogeneity of the perinodal matrix, and its nodal expression is dependent on Bral1.
this shows a heterophilic molecular interaction between cell adhesion molecular L1 and neurocan is involved in determining the thalamocortical pathway within the neocortical anlage
PTPsigma binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma; results indicate PTPsigma can act as a receptor for CSPGs
Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.
chondroitin sulfate proteoglycan 3 (neurocan)
, 245 kDa early postnatal core glycoprotein
, chondroitin sulfate proteoglycan 3
, neurocan core protein
, neurocan proteoglycan
, TGFbeta-induced transcript, brain
, chondroitin sulfate proteoglycan 3, related sequence