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Collectively, the data suggest that Cytl1 plays an essential role in cardiac fibrosis likely through activating the TGF-beta (显示 TGFB1 蛋白)-SMAD (显示 SMAD1 蛋白) signaling pathway.
C17 as a cytokine that s contributes to immune homeostasis systemically or in a tissue-specific manner in the joint
results suggest that, rather than regulating cartilage and bone development, Cytl1 is required for the maintenance of cartilage homeostasis, and loss of Cytl1 function is associated with experimental OA cartilage destruction in mice
chondrocyte-specific Cytl1 regulates chondrogenesis as a novel autocrine factor, but not hypertrophic maturation of chondrocytes during cartilage development
Circular dichroism analysis showed that, like chemokines, CYTL1has a higher content of beta-sheet than alpha-helix secondary structure; recombinant CYTL1 promoted calcium flux in chondrocytes; unlike chemokines, CYTL1 had limited affinity to proteoglycans; together, these properties further support cytokine-like properties for CYTL1 with some overlap with the chemokines
this study shows that CYTL1 possesses chemotactic activity and demonstrates that its functional receptor is CCR2B (显示 CCR2 蛋白)
when the native signal peptide of CYTL1 was replaced by IgGkappaSP, the expression and secretion was increased by 4 fold.
Cytl1 is highly expressed in the endometrium during the embryo implantation and its expression is regulated by ovarian hormones. Cytl1 enhances endometrial proliferation, induces the secretion of endometrial LIF (显示 LIF 蛋白) and HB-EGF (显示 HBEGF 蛋白), and even enhances endometrial cell adhesion to trophoblastic cells. These indicate that Cytl1 is a potential molecular mediator of embryo is a potential molecular mediator in embryo implantation.
our results showed the first evidence of CYTL1 expression in SH-SY5Y neuroblastoma (显示 ARHGEF16 蛋白) cells and human NB tissues, revealed a possible link between CYTL1 and NB development
evidence suggests that ANKRD7 and CYTL1 genes may play an important role in the variance in alcohol drinking risk
C17orf62-L could induce cell death accompanied with rising of cleaved PARP.
The DNA methylation (显示 HELLS 蛋白) pattern of the CYTL1 promoter region was significantly different between early and advanced stages of squamous cell carcinoma.
We report a structural-functional characterization of cytokine-like protein 1 (Cytl1) by a combination of different computational structure-based techniques.
C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker (Liu et al., 2000
cytokine-like protein 1
, cytokine like 1
, cytokine-like protein C17
, cytokine-like 1