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GNAZ mutations are associated with melanoma.
cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin (显示 GNAT1 蛋白), through Wnt5a (显示 WNT5A 蛋白)-Frizzled-2 (显示 FZD2 蛋白) cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization.
findings suggest that Galphaz signals may attenuate Rho-induced stimulation of SRF-mediated transcription
present study suggest that Gnaz links the circadian clockwork-via dopamine acting on D4 receptors-to G protein-mediated signaling in intact but not diabetic retina
a novel role of Galpha (显示 SUCLG1 蛋白)(z) in restraining myogenic differentiation through the disruption of Rho signaling
activation attenuates Rap1-mediated differentiation of PC12 cells.
The active form of Galpha (显示 SUCLG1 蛋白)(z), but not Galpha (显示 SUCLG1 蛋白)(i2), is crucial for maintenance of the structure of the Golgi apparatus
Galpha (显示 SUCLG1 蛋白)(z) knock-out mice display high levels of anxiety-like behaviour and are less sensitive to the action of 8-OH-DPAT. Balb/c mice show much more clear effects of the Galpha (显示 SUCLG1 蛋白)(z) knock-out than C57Bl/6 mice.
The Gnaz protein exert a negative control on Src (显示 SRC 蛋白) function reducing the activating influence of Receptors, Opioid, mu on this tyrosine kinase (显示 TYRO3 蛋白) in neural cells.
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
g(x) alpha chain
, guanine nucleotide-binding protein G(z) subunit alpha
, transducin alpha
, Guanine nucleotide binding protein alpha
, guanine nucleotide binding protein, alpha z polypeptide
, guanine nucleotide binding protein, alpha z subunit