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GNAZ mutations are associated with melanoma.
cGMP-phosphodiesterase 6 can be activated by another cancer-retina antigen, transducin, through Wnt5a-Frizzled-2 cascade, which leads to a lowering of cGMP and an increase in intracellular calcium mobilization.
findings suggest that Galphaz signals may attenuate Rho-induced stimulation of SRF-mediated transcription
present study suggest that Gnaz links the circadian clockwork-via dopamine acting on D4 receptors-to G protein-mediated signaling in intact but not diabetic retina
Galphaz plays a key role in beta-cell signaling that becomes dysfunctional in the type 1 diabetes setting, accelerating the death of beta-cells, which promotes further accumulation of immune cells in the pancreatic islets, and inhibiting a restorative proliferative response.
Deletion of GalphaZ protein protects against diet-induced glucose intolerance via expansion of beta-cell mass.
a novel role of Galpha(z) in restraining myogenic differentiation through the disruption of Rho signaling
The survival of sympathetic and sensory neurons was examined in the G(z alpha) deficient mouse and in the presence of pertussis toxin, sympathetic but not sensory neuronal survival in G(z alpha) deficient mice was significantly attenuated.
activation attenuates Rap1-mediated differentiation of PC12 cells.
The active form of Galpha(z), but not Galpha(i2), is crucial for maintenance of the structure of the Golgi apparatus
Gz signaling pathways are involved in transducing the analgesic and lethality effects of morphine following chronic morphine treatment.
Galpha(z) knock-out mice display high levels of anxiety-like behaviour and are less sensitive to the action of 8-OH-DPAT. Balb/c mice show much more clear effects of the Galpha(z) knock-out than C57Bl/6 mice.
Gz proteins are also responsible for the long-term analgesic tolerance produced by single doses of these agonists, as well as for the cross-tolerance between CB1Rs and mu-opioid receptors.
The Gnaz protein exert a negative control on Src function reducing the activating influence of Receptors, Opioid, mu on this tyrosine kinase in neural cells.
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systms. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.
g(x) alpha chain
, guanine nucleotide-binding protein G(z) subunit alpha
, transducin alpha
, Guanine nucleotide binding protein alpha
, guanine nucleotide binding protein, alpha z polypeptide
, guanine nucleotide binding protein, alpha z subunit