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GNAT3 抗体

(Guanine Nucleotide Binding Protein, alpha Transducing 3 (GNAT3))
Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase\; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultimately leading to release of neurotransmitter. Indeed, denatonium and strychnine induce transient reduction in cAMP and cGMP in taste tissue, whereas this decrease is inhibited by GNAT3 antibody. Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit, as well as via activation of phospholipase C for beta and gamma subunits, with ultimate increase inositol trisphosphate and increase of intracellular Calcium. GNAT3 can functionally couple to taste TAS1R2/TAS1R3 senses sweetness and TAS1R1/TAS1R3 transduces umami taste, whereas the T2R family GPCRs act as bitter sensors. Functions also as lumenal sugar sensors in the gut to control the expression of the Na+-glucose transporter SGLT1 in response to dietaty sugar, as well as the secretion of Glucagon-like peptide- 1, GLP-1 and glucose-dependent insulinotropic polypeptide, GIP. Thus, may modulate the gut capacity to absorb sugars, with implications in malabsorption syndromes and diet-related disorders including diabetes and obesity.
GNAT3 抗体 GNAT3 抗体 GNAT3 抗体 (ABIN7243340)

GNAT3 适用: 人, 小鼠, 大鼠 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated

GNAT3 抗体  (AA 2-354) GNAT3 抗体  (AA 2-354) GNAT3 抗体 (AA 2-354) (ABIN7154719)

GNAT3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

GNAT3 抗体  (AA 60-130) GNAT3 抗体  (AA 60-130) GNAT3 抗体 (AA 60-130) (ABIN7267544)

GNAT3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

GNAT3 抗体 by Grade

Find GNAT3 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

GNAT3 抗体 by 适用

Find GNAT3 抗体 for a variety of species such as anti-Human GNAT3, anti-Mouse GNAT3, anti-Rat GNAT3. The species listed below are among those available. Click on a link to go to the corresponding products.

GNAT3 抗体 by 应用范围

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GNAT3 抗体 by 抗原表位

Find GNAT3 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

GNAT3 抗体 by 克隆形成能力

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GNAT3 抗体 by 克隆

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GNAT3 抗体 by 标记

Find GNAT3 抗体 with a specific conjugate such as Biotin, FITC, HRP. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular GNAT3 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC, WB
Validations
  • (3)
Cat. No. ABIN7243340
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7154719
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN7267544
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (3)
Cat. No. ABIN654441
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p), EIA
Validations
  • (3)
Cat. No. ABIN952565
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN335139
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7154722
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7154721
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7154720
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN2604118
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN1899075
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN1899074
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN1899071
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN1899073
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB, FACS
Validations
Cat. No. ABIN1899072
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our GNAT3 抗体

Jang, Kokrashvili, Theodorakis, Carlson, Kim, Zhou, Kim, Xu, Chan, Juhaszova, Bernier, Mosinger, Margolskee, Egan: "Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 38, pp. 15069-74, (2007) (PubMed).

Ma, Sheng, Zhang, Zhang, He, Huang, Chen, Sultz, Adegboyega, Zhang, Xie: "Hedgehog signaling is activated in subsets of esophageal cancers." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 1, pp. 139-48, (2005) (PubMed).

Aliases for GNAT3 抗体

G protein subunit alpha transducin 3 (GNAT3) 抗体
guanine nucleotide binding protein, alpha transducing 3 (Gnat3) 抗体
G protein subunit alpha transducin 3 (Gnat3) 抗体
GDCA 抗体
Ggust 抗体
gnat-3 抗体
Gtn 抗体
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