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Gnai1 function is impaired in the spinal cord of Ews/Ewsr1 (显示 EWSR1 ELISA试剂盒) KO mice
LGN (显示 GPSM2 ELISA试剂盒) and Galphai participate in a long-inferred signal that originates outside the bundle to model its staircase-like architecture, a property that is essential for direction sensitivity to mechanical deflection and hearing.
stimulation of GPR17 (显示 GPR17 ELISA试剂盒) by the small molecule agonist MDL29,951 (2-carboxy-4,6-dichloro-1H-indole-3-propionic acid) decreases myelin basic protein (显示 MBP ELISA试剂盒) expression levels mainly by triggering the Galphai/o signaling pathway.
Gnai1 missense mutation is responsible of hyperpigmentation in mouse model.
acidosis in inflamed tissues may be a decisive factor to regulate switching of PKA and PKCepsilon dependence via proton-sensing G-protein-coupled receptors.
Data show that guanine nucleotide-binding protein G(i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.
By using mice deficient in individual Galphai/o G-protein subunits, authors demonstrate that Galphai1 and Galphai3 are the critical in vivo targets of ADP-ribosylation underlying vasoactive amine sensitization elicited by pertussis toxin exposure.
leucine can directly facilitate insulin (显示 INS ELISA试剂盒) signaling through a Galphai protein-dependent intracellular signaling pathway
Inactive Galpha(i1)-GDP enhances the affinity of RGS14 for H-Ras-GTP in live cells, resulting in a ternary signaling complex that is further regulated by G protein-coupled receptors.
Mice with mutations of Gnai1 or Gnai2 (显示 GNAI2 ELISA试剂盒) have neither fusions of ribs nor lumbar vertebrae, but loss of both Gnai3 (显示 GNAI3 ELISA试剂盒) and one of the other two genes increases the number and severity of rib fusions without affecting the lumbar fusions.
GIV (显示 CCDC88A ELISA试剂盒) is a bifunctional modulator of G proteins; it serves as a guanine nucleotide dissociation inhibitor (GDI) for Galphas (显示 GNAS ELISA试剂盒) using the same motif that allows it to serve as a guanine-nucleotide exchange factor (显示 RASGRF1 ELISA试剂盒) for Galphai
The authors demonstrate that Glu53, Glu60, and Glu118 of human Ngb (显示 GTPBP4 ELISA试剂盒) are crucial for both the neuroprotective activity and interaction with Gi. Moreover, they show that Lys46, Lys70, Arg208, Lys209, and Lys210 residues of Gi are important for binding to human Ngb (显示 GTPBP4 ELISA试剂盒).
GTP (显示 AK3 ELISA试剂盒) analogs leads to a rigid and closed arrangement of the Galphai1, whereas the apo (显示 C9orf3 ELISA试剂盒) and GDP-bound forms are considerably more open and dynamic.
The results show ZIP9 (显示 SLC39A9 ELISA试剂盒) is a specific Gi coupled-membrane AR mediating testosterone-induced MAP kinase (显示 MAPK1 ELISA试剂盒) and zinc signaling in PC3 (显示 PCSK1 ELISA试剂盒)-ZIP9 (显示 SLC39A9 ELISA试剂盒) cells.
These data indicate that, unlike in taste cells, TAS2Rs couple to the prevalent G proteins, Galphai1, Galphai2 (显示 GNAI2 ELISA试剂盒), and Galphai3 (显示 GNAI3 ELISA试剂盒), with no evidence for functional coupling to Galphagust.
testosterone rapidly increased whole-cell HCAEC SKCa and BKCa (显示 KCNMA1 ELISA试剂盒) currents via a surface androgen receptor (显示 AR ELISA试剂盒), Gi/o protein, and protein kinase A
These findings suggest that Gi1 interacts only with active GPCRs and that the well known high speed of GPCR signal transduction does not require preassembly between G proteins and GPCRs.
CGRP (显示 S100A12 ELISA试剂盒) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (显示 GNAS ELISA试剂盒), Galphai, and Galphaq (显示 GNAQ ELISA试剂盒)/11 pathways.
biochemical and computational data indicate that the interactions between alpha5, alpha1, and beta2-beta3 are not only vital for GDP release during G protein activation, but they are also necessary for proper GTP binding (显示 RND2 ELISA试剂盒) (or GDP rebinding).
Data indicate that hydroxyurea (HU) induces SAR1 (显示 IQGAP1 ELISA试剂盒) protein expression, which in turn activates gamma-globin (显示 HBG1 ELISA试剂盒) expression, predominantly through the Gialpha/JNK (显示 MAPK8 ELISA试剂盒)/Jun (显示 JUN ELISA试剂盒) pathway.
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene.
adenylate cyclase-inhibiting G alpha protein
, guanine nucleotide binding protein, alpha inhibiting 1
, guanine nucleotide-binding protein G(i) subunit alpha-1
, Gi1 protein alpha-subunit
, alpha-subunit of G-protein, type G-alpha-i-1
, guanine nucleotide-binding protein G(i), alpha-1 subunit
, Gi1 protein alpha subunit
, Gi-alpha-1 protein
, guanine nucleotide binding protein (G protein), alpha inhibiting 1
, Galpha i1a