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Results show that postzygotic mosaicism for GNA11 mutations causes an overlapping phenotypic spectrum of vascular and melanocytic birthmarks.
GNAQ/GNA11Q209 mutations characterized a distinct, albeit uncommon subtype of non-uveal melanoma (0.5-1%). These mutations were essentially melanoma-specific, occurred in all subtypes of this disease (including cutaneous, mucosal, uveal, and unknown primary), and were mutually exclusive with other common melanoma mutations.
GNA11 mutations are associated with extremity capillary malformations causing overgrowth.
There were no significant differences in the prevalence of GNAQ (显示 GNAQ 蛋白) and GNA11 mutations between patients with or without metastatic disease
a novel germline gain-of-function Galpha11 mutation, Val340Met, causing Autosomal Dominant Hypocalcemia Type 2 demonstrates the importance of the Galpha11 C-terminal region for G-protein function and CaSR (显示 CASR 蛋白) signal transduction.
studies have identified a third Galpha11 mutation (Thr54Met) causing Familial Hypocalciuric Hypercalcemia Type 2 and reveal a critical role for the Galpha11 interdomain interface in CaSR (显示 CASR 蛋白) signaling and Ca(2 (显示 CA2 蛋白)+) o homeostasis.
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (显示 SOX10 蛋白) expression and presence of the BRAF (显示 BRAF 蛋白) V600E mutation.
Mutations in GNAQ (显示 GNAQ 蛋白) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (显示 GNAQ 蛋白), GNA11, and EIF1AX (显示 EIF1AX 蛋白) mutations.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone (显示 PTH 蛋白) and exercise
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (显示 TGFB1 蛋白) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (显示 IL33 蛋白) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (显示 GNAQ 蛋白)/11-dependent fashion.
claudin-3 (显示 CLDN3 蛋白) and claudin-5 (显示 CLDN5 蛋白) expression is increased by DHEAS (显示 SULT2A1 蛋白) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (显示 GNAQ 蛋白)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (显示 OPN4 蛋白) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (显示 GNAQ 蛋白)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (显示 SULT2A1 蛋白))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (显示 GPR34 蛋白), since silencing of Gnalpha11 leads to the abolition of the DHEAS (显示 SULT2A1 蛋白)-induced stimulation of Erk1/2, ATF-1 (显示 AFT1 蛋白), and CREB (显示 CREB1 蛋白).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (显示 MAPK1 蛋白) cascade via the Galpha(q (显示 GNAQ 蛋白)/11)--p63RhoGEF--RhoA (显示 RHOA 蛋白) axis.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit