Use your antibodies-online credentials, if available.
DACH1 expression is decreased in glomerulopathy imply a potential role for DACH1 in the this development of human chornic glomerulopathy.
Knockdown of DACH1 expression can remarkably enhance the cell apoptosis, restrain the proliferation, migration and invasion of Capan-1 cells.
DACH1 expression regulates the pancreatic cancer cell apoptosis.
Low DACH1 expression is associated with invasion of lung adenocarcinoma.
This study concludes that MiR (显示 MLXIP 蛋白)-217 is the upstream regulator of PGC-1alpha in breast cancer regulation in vitro, possibly independent of DACH1 signaling pathway.
Kaplan-Mier analysis of human NSCLC samples demonstrated that high DACH1 mRNA levels predicted favorable prognosis for relapse-free and overall survival. In agreement, high CXCL5 (显示 CXCL5 蛋白) expression predicted a worse prognosis for survival.
DACH1 expression was reduced in hepatocellular carcinoma even at early stage and associated with tumor progression. Overexpression inhibited HCC (显示 FAM126A 蛋白) cell growth and migration by inactivating the Wnt (显示 WNT2 蛋白) pathway via GSK3beta phosphorylation to suppress beta-catenin (显示 CTNNB1 蛋白).
In breast cancer, some GATA3 (显示 GATA3 蛋白) effects shift from tumor suppressing to tumor promoting during tumorigenesis, with deregulation of three genes, BCL2 (显示 BCL2 蛋白), DACH1, THSD4 (显示 THSD4 蛋白), representing major GATA3 (显示 GATA3 蛋白)-controlled processes in cancer progression.
Results indicated that DACH1 was a novel molecular marker of RCC (显示 XRCC1 蛋白) and it attributed to the malignant behavior of renal cancer cells.
Data indicate that dachshund family transcription factor 1 (显示 HNF1A 蛋白) (DACH1) suppresses gastric cancer cell proliferation, invasion and metastasis by inhibiting transforming growth factor beta (TGF-beta) signalling pathways both in vitro and in vivo.
DACH1 stimulates coronary artery growth by activating Cxcl12 (显示 CXCL12 蛋白) expression and endothelial cell migration against blood flow into developing arteries
HDAC4 (显示 HDAC5 蛋白)-mediated SUMOylation of the corepressor DACH1 is decreased, which protects DACH1 from proteasomal degradation
The results of this study suggested the involvement of the mouse Dach1 gene in adult neurogenesis; cells expressing this gene exhibit the properties of adult NSCs or neuroblasts and respond to MCAo by enhanced neurogenesis.
find that in cells growing in IGF-1 (显示 IGF1 蛋白) (and unresponsive to EGF (显示 EGF 蛋白)), DACH1 is devoid of tumor suppressor activity
The mouse dachshund gene is related to the Ski (显示 SKI 蛋白) proto-oncogene (显示 RAB1A 蛋白) and is expressed in eye and limb.
In the mouse, Dach1 expression in the developing ear also overlaps with the expression of Eya1 (显示 EYA1 蛋白) (an eya homologue)
Dach1 is a target gene of FGF signaling during limb skeletal development, and Dach1 may function as an intermediary in the FGF signaling pathway regulating cell proliferation or differentiation
Dach1 is critical for postnatal survival of mice
The phosphatase function of Eya switches the function of Six1 (显示 SIX1 蛋白)-Dach from repression to activation, causing transcriptional activation through recruitment of co-activators
The Pax (显示 PXN 蛋白)-Eya-Six-Dach network is at best only partly conserved during lens and nasal placode development.
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene.
dachshund homolog 1
, dachshund homolog 1 (Drosophila)
, dachshund 1
, dachshund protein
, dachshund homolog 1-like