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Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 (显示 MMP2 蛋白) and MMP9 (显示 MMP9 蛋白) through PI3 kinase (显示 PIK3CA 蛋白)/Akt (显示 AKT1 蛋白) protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 (显示 PPARG 蛋白) regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
miR (显示 MLXIP 蛋白)-152 controls both the expression of 14-3-3beta and HLA-G (显示 HLAG 蛋白) and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT (显示 PARP1 蛋白), APAF1 (显示 APAF1 蛋白), BCL2 (显示 BCL2 蛋白), BAD, BID (显示 BID 蛋白), MCL1 (显示 MCL1 蛋白), BIRC4 (显示 XIAP 蛋白), BCL2L1 (显示 BCL2L1 蛋白), ENDOG (显示 ENDOG 蛋白), YWHAB, and YWHAQ (显示 YWHAQ 蛋白), influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c (显示 MYO1C 蛋白)/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin (显示 INS 蛋白)-stimulated glucose uptake.
Data identified three classes of 14-3-3 (显示 YWHAQ 蛋白) targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
14-3-3beta binding to phosphorylated CFTR (显示 CFTR 蛋白) augments its biogenesis by reducing retrograde retrieval of CFTR (显示 CFTR 蛋白) to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR (显示 CFTR 蛋白) available for anion secretion.
Data identified 14-3-3beta as a prognostic biomarker.
Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R (显示 CNR1 蛋白)).
SelW (显示 SEPW1 蛋白) enhances myoblast differentiation by inhibiting TAZ (显示 TAZ 蛋白) binding to 14-3-3 (显示 YWHAQ 蛋白).
Studies suggest that insulin (显示 INS 蛋白) may modulate the cellular function of lipin-1 (显示 LPIN1 蛋白) by regulating its subcellular localization through interactions with 14-3-3 (显示 YWHAQ 蛋白) proteins.
14-3-3 (显示 YWHAQ 蛋白) participates in the intracellular trafficking of IRS-1 (显示 IRS1 蛋白)
The transcription start site was identified and the polyadenylation signals (AATAAA) were found in exon 2 of the mouse gene. In the 5'-upstream sequence, we found three cis (显示 CISH 蛋白) elements including a CRE sequence, a TATA box-like sequence, and a C/EBP (显示 CEBPA 蛋白) element.
PRAS40 (显示 AKT1S1 蛋白) is a novel substrate of Akt (显示 AKT1 蛋白), the phosphorylation of which leads to the binding of this protein to 14-3-3 (显示 YWHAQ 蛋白).
14-3-3beta is a p90 (显示 GPAM 蛋白) ribosomal S6 kinase (显示 RPS6KB1 蛋白) (RSK (显示 RPS6KA1 蛋白)) isoform 1-binding protein that negatively regulates RSK (显示 RPS6KA1 蛋白) kinase activity
14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo.
These results indicate for the first time that 14-3-3 protein (显示 YWHAE 蛋白) plays a critical anti-apoptotic role in diabetic myocardium by inhibiting the JNK (显示 MAPK8 蛋白) pathway.
aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 (显示 NEDD4L 蛋白) to block its interaction with ENaC (显示 SCNN1A 蛋白), thus enhancing sodium absorption by increasing apical membrane ENaC (显示 SCNN1A 蛋白) density
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
, 14-3-3 protein beta/alpha
, brain protein 14-3-3, beta isoform
, protein 1054
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
, 14-3-3 protein beta
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
, 14-3-3 protein beta/alpha-2
, 14-3-3 protein beta/alpha-B
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 2
, 14-3-3 protein beta-subtype
, 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
, prepronerve growth factor RNH-1
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide
, 14-3-3 beta
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide