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Our results indicate that 14-3-3beta negatively regulates senescence in glioblastoma cells via the ERK/SKP2/p27 pathway.
14-3-3beta protein activates Pseudomonas exotoxin-S and exotoxin-T ADP-ribosyltransferase domains by chaperoning their hydrophobic surfaces independently of the amphipathic C-terminal segment.
Data show that 14-3-3beta protein augmented the expression of matrix metalloproteinasea MMP2 and MMP9 through PI3 kinase/Akt protein/NF-kappaappa B pathway, thereby enhancing the invasiveness of hepatocellular carcinoma (HCC) cells.
These findings indicate that 14-3-3beta and gamma are novel PPARgamma2 regulators and are involved in hepatic lipid metabolism. 14-3-3b and gamma can be therapeutic target molecules to treat non-alcoholic fatty liver disease.
miR-152 controls both the expression of 14-3-3beta and HLA-G and exerts a dual role in tumor cells by both altering the immunogenicity and the tumorigenicity
Data suggest that serum 14-3-3beta concentrations may constitute a useful marker for blood brain barrier damage severity and follow up in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis.
Using gene reporter assays, we show that promoter variations in 11 intrinsic apoptosis genes, including ADPRT, APAF1, BCL2, BAD, BID, MCL1, BIRC4, BCL2L1, ENDOG, YWHAB, and YWHAQ, influence promoter activity in an allele-specific manner.
Crystal structure of Myo1c/14-3-3beta complex, which has been implicated in the exocytosis of glucose transporter 4 storage vesicles during insulin-stimulated glucose uptake.
Data identified three classes of 14-3-3 targets that all have two binding sites, but displayed synergistic interaction between converging signalling pathways for different ranges of parameter values.
These results indicate that the six YWHAB polymorphisms are not associated with the genetic susceptibility to sporadic Creutzfeldt-Jakob disease.
14-3-3beta binding to phosphorylated CFTR augments its biogenesis by reducing retrograde retrieval of CFTR to the endoplasmic reticulum. This mechanism permits cAMP/PKA stimulation to make more CFTR available for anion secretion.
Data identified 14-3-3beta as a prognostic biomarker.
Modulation of matrix metalloproteinase 1 by 14-3beta/alpha, may be important in the alteration of collagenase production associated with airway remodelling in obstructive lung diseases
Analyses show that high cytoplasmic levels of 14-3-3beta and epsilon independently correlate with poor disease-specific survival in vulvar squamous cell carcinoma cases.
In glioblastoma PTPIP51 expression increases with the grade of malignancy and PTPIP51 interacts in situ with 14-3-3ss and PTP1B.
Studies indicate that Akt phosphorylates acetylated-FoxO and then phosphorylated FoxO interacts with 14-3-3 proteins in the nucleus, which in turn results in cytoplasmic retention of FoxO.
Studies indictet that the mammalian FoxO family consists of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3 proteins.
The expression levels of 14-3-3 protein beta/alpha were higher in urine samples from patients with renal cell carcinoma than in samples from healthy volunteers.
Data indicate that gene analysis revealed an up-regulation of all four 14-3-3 isoforms beta, eta, gamma, and sigma.
14-3-3beta protein has the potential to be used as a diagnostic and prognostic biomarker in gastric cancer.
Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R).
SelW enhances myoblast differentiation by inhibiting TAZ binding to 14-3-3.
the novel protein interaction mode in the 14-3-3beta.ChREBP alpha2 complex.
Studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins.
14-3-3 participates in the intracellular trafficking of IRS-1
The transcription start site was identified and the polyadenylation signals (AATAAA) were found in exon 2 of the mouse gene. In the 5'-upstream sequence, we found three cis elements including a CRE sequence, a TATA box-like sequence, and a C/EBP element.
PRAS40 is a novel substrate of Akt, the phosphorylation of which leads to the binding of this protein to 14-3-3.
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo.
These results indicate for the first time that 14-3-3 protein plays a critical anti-apoptotic role in diabetic myocardium by inhibiting the JNK pathway.
aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density
Cbl-b deficiency. Cbl-b deficiency resulted in increased phosphorylation of T758 in the beta2-chain of LFA-1 and thereby in enhanced association of 14-3-3beta protein with the beta2-chain
FBI1 and 14-3-3beta were presented on the MKP-1 promoter. These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis.
aldosterone-induced 14-3-3 isoforms, beta and epsilon, interact with phospho-Nedd4-2 as an obligatory heterodimer, blocking its interaction with ENaC and thereby increasing apical ENaC density and sodium transport.
Akt1 is necessary for the growth factor stimulated activation of 14-3-3beta-Rac1-p21 activated kinase (Pak) pathway in endothelial cells and fibroblasts.
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene.
, 14-3-3 protein beta/alpha
, brain protein 14-3-3, beta isoform
, protein 1054
, protein kinase C inhibitor protein 1
, protein kinase C inhibitor protein-1
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
, 14-3-3 protein beta
, tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide
, 14-3-3 protein beta/alpha-2
, 14-3-3 protein beta/alpha-B
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 2
, 14-3-3 protein beta-subtype
, 3-monooxygenase/tryptophan 5 monooxygenase activation protein beta polypeptide
, prepronerve growth factor RNH-1
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide
, tryosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide
, tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, beta polypeptide
, tyrosine 3/tryptophan 5 -monooxygenase activation protein beta polypeptide
, 14-3-3 beta
, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide