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Nur77 suppresses CD4 (显示 CD4 蛋白)(+) T cell proliferation and uncover a suppressive role for Irf4 (显示 IRF4 蛋白) in TH2 polarization; halving Irf4 (显示 IRF4 蛋白) gene-dosage leads to increases in GATA3 (显示 GATA3 蛋白)(+) and IL-4 (显示 IL4 蛋白)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (显示 WT1 蛋白) promoter, and enhanced WT1 (显示 WT1 蛋白) promoter transactivation and knockdown of WT1 (显示 WT1 蛋白) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (显示 WT1 蛋白) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (显示 PRL 蛋白)) and insulin-like growth factor binding protein-1 (IGFBP-1 (显示 IGFBPI 蛋白)) expression and transformation in vitro.
DNMT1 (显示 DNMT1 蛋白) causes NR4A1 DNA hypermethylation and blocks insulin (显示 INS 蛋白) signaling in an Chinese patients with type 2 diabetes
Data show that nuclear receptor 4A1 (NR4A1) knockdown and the C-DIM/NR4A1 antagonists were comparable as inhibitors of NR4A1-dependent genes/pathways.
mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed.
NR4A sub-family of nuclear orphan receptors (Nor-1 (显示 NR4A3 蛋白), Nurr-1 (显示 NR4A2 蛋白) and Nur-77) may have a role in trophoblastic cell differentiation.
beta1-integrin expression is regulated in pancreatic and colon cancer cells by the pro-oncogenic orphan nuclear receptor 4A1
Inhibition of NR4A1-mediated transcriptional activity was involved in the anticancer effects of fangchinoline; fangchinoline represents a novel class of mechanism-based anticancer agents targeting NR4A1 that is overexpressed in pancreatic cancer.
Transcript analysis of four different aggressive lymphoma cell lines overexpressing either NR4A3 (显示 NR4A3 蛋白) or NR4A1 revealed that apoptosis was driven similarly by induction of BAK (显示 BAK1 蛋白), Puma (显示 BBC3 蛋白), BIK (显示 BIK 蛋白), BIM (显示 BCL2L11 蛋白), BID (显示 BID 蛋白), and Trail. Overall, our results showed that NR4A3 (显示 NR4A3 蛋白) possesses robust tumor suppressor functions of similar impact to NR4A1 in aggressive lymphomas
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
These results suggest that berberine-induced activation of AMPK (显示 PRKAA1 蛋白) may contribute to hepatic FGF21 (显示 FGF21 蛋白) expression via NUR77.
we found that KLF6 (显示 KLF6 蛋白) transcriptionally cooperates with NUR77 and SF1 (显示 SF1 蛋白)
Ca(2 (显示 CA2 蛋白)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (显示 MEF2C 蛋白), AP1 (显示 JUN 蛋白), and CREB (显示 CREB1 蛋白) transcription factors thus demonstrating an important interplay between the Ca(2 (显示 CA2 蛋白)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (显示 BCL2L11 蛋白) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
Celastrol promotes Nur77 migration from the nucleus to mitochondria, where it is ubiquitinated by TRAF2 (显示 TRAF2 蛋白). Ubiquitinated Nur77 then interacts with p62/SQSTM1 (显示 SQSTM1 蛋白), leading to autophagy of dysfunctional mitochondria and alleviation of inflammation.
New transcript variants encode for NUR77 protein isoforms which are significantly smaller in size due to lack of transactivation domain and a part of DNA binding domain. Western blot analysis using NUR77 specific antibody confirmed the existence of these smaller variants in mouse.
Nur77 deficiency compromises myofiber growth, but not the regenerative capacity of myogenic progenitor cells.
Using Nr4a1 transgenic mice, electrically evoked dopamine release was shown to differ between the striosome and matrix compartments of the corpus striatum in a regionally-distinct manner.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B