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we show here that the BCR (显示 BCR 蛋白)/BTK (显示 BTK 蛋白) target gene NR4A1 is a potential oncogene (显示 RAB1A 蛋白) in mantle cell lymphoma
this study confirmed that NR4A1 sensitizes gastric cancer cells to TNFalpha (显示 TNF 蛋白)-induced apoptosis through the inhibition of JNK (显示 MAPK8 蛋白)/Parkin (显示 PARK2 蛋白)-dependent mitophagy.
Inhibition of NR4A1 in stromal cells increased the TGF-beta1 (显示 TGFB1 蛋白)-dependent elevated expression of fibrotic markers, and loss of NR4A1 stimulated fibrogenesis in mice with endometriosis.
NR4A1 knockdown partly decreased surface NR2B (显示 GRIN2B 蛋白) by promoting NR2B (显示 GRIN2B 蛋白) internalization.
Data show that SUMOylation is critical in controlling NR4A1 function in inflammatory cytokine signaling and controlling macrophage cell death.
our findings suggest that hypoxia-induced down-regulation of TR3 might play an important role for hypoxia-induced apoptosis resistance in NSCLC.
Nur77 suppresses CD4 (显示 CD4 蛋白)(+) T cell proliferation and uncover a suppressive role for Irf4 (显示 IRF4 蛋白) in TH2 polarization; halving Irf4 (显示 IRF4 蛋白) gene-dosage leads to increases in GATA3 (显示 GATA3 蛋白)(+) and IL-4 (显示 IL4 蛋白)(+) cells.
our data demonstrated that NR4A1 protein physically associates with the WT1 (显示 WT1 蛋白) promoter, and enhanced WT1 (显示 WT1 蛋白) promoter transactivation and knockdown of WT1 (显示 WT1 蛋白) in MIN6 cells induced apoptosis. These findings suggest that NR4A1 protects pancreatic beta-cells against H2O2 mediated apoptosis by up-regulating WT1 (显示 WT1 蛋白) expression.
NR4A modulates the decidualization of hESCs by upregulating prolactin (PRL (显示 PRL 蛋白)) and insulin-like growth factor binding protein-1 (IGFBP-1 (显示 IGFBPI 蛋白)) expression and transformation in vitro.
DNMT1 (显示 DNMT1 蛋白) causes NR4A1 DNA hypermethylation and blocks insulin (显示 INS 蛋白) signaling in an Chinese patients with type 2 diabetes
Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells.
we found that either knockdown of Nr4a1 or 3, 3'- Diindolylmethane (DIM), an Nr4a1 antagonist, were able to rescue the effects of SNRPN (显示 SNRPN 蛋白) knockdown on neurite outgrowth of embryonic cortical neurons, providing the potential therapeutic methods for SNRPN (显示 SNRPN 蛋白) deletion disorders. We thus concluded that maintaining the proper level of SNRPN (显示 SNRPN 蛋白) is critical in cortical neurodevelopment.
new insights into the understanding the mechanisms of the effects of Nur77 on LPS (显示 TLR4 蛋白)-activated microglia
These results suggest that berberine-induced activation of AMPK (显示 PRKAA1 蛋白) may contribute to hepatic FGF21 (显示 FGF21 蛋白) expression via NUR77.
we found that KLF6 (显示 KLF6 蛋白) transcriptionally cooperates with NUR77 and SF1 (显示 SF1 蛋白)
Ca(2 (显示 CA2 蛋白)+) signaling pathway increases Nr4a1 expression in MA-10 Leydig cells, at least in part, by enhancing the recruitment of coactivator most likely through the MEF2 (显示 MEF2C 蛋白), AP1 (显示 JUN 蛋白), and CREB (显示 CREB1 蛋白) transcription factors thus demonstrating an important interplay between the Ca(2 (显示 CA2 蛋白)+) and cAMP pathways in regulating Nr4a1 expression.
additional loss of Nur77 in the absence of Bim (显示 BCL2L11 蛋白) led to diabetes induction, suggesting that Nur77 promotes tolerance in this context. Together, these data reveal novel nondeletional roles for Nur77 that differ between T cell subsets and have implications for self-tolerance.
current data identify Nr4a1 as regulator of microglia activation and potentially new target for the treatment of inflammatory CNS diseases such as multiple sclerosis.
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
, TR3 orphan receptor
, early response protein NAK1
, growth factor-inducible nuclear protein N10
, hormone receptor
, nerve growth factor IB nuclear receptor variant 1
, nuclear hormone receptor NUR/77
, nuclear receptor subfamily 4 group A member 1
, orphan nuclear receptor HMR
, orphan nuclear receptor TR3
, steroid receptor TR3
, testicular receptor 3
, orphan nuclear receptor NGFI-B
, nuclear protein N10
, Orphan nuclear receptor HMR
, immediate early gene transcription factor NGFI-B
, nerve growth factor induced protein I-B
, nerve growth factor-induced protein I-B