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Rat (Rattus) KL Protein expressed in Escherichia coli (E. coli) - ABIN2123130
Wu, Lv, Chen, Ma, Shao, Wang: The function of miR-199a-5p/Klotho regulating TLR4/NF-?B p65/NGAL pathways in rat mesangial cells cultured with high glucose and the mechanism. in Molecular and cellular endocrinology 2015
The change in concentration of soluble alpha-klotho during the 1.5-years follow-up was an indicator of CKD progression. Renal damage associated with a reduction of alpha-klotho may involve the upregulation of plasma aldosterone.
Cord blood klotho levels were inversely correlated with leptin (显示 LEP 蛋白) and insulin (显示 INS 蛋白) levels at birth
serum level of FGF-23 (显示 FGF23 蛋白) was not correlated with a change in bone mineral density of maintenance hemodialysis patients, whereas the serum Klotho protein level was associated with the degree of bone mineral density
solubility-Klotho level was closely correlated with kidney function
To evaluate the role of klotho in the pathogenesis of systemic sclerosis, its serum concentration was measured in patients compared to healthy controls, and its association with cutaneous and visceral involvement was assessed. Spearman's test showed no significant association between klotho serum levels and systemic sclerosis activity, concerning either clinical, laboratory or instrumental findings.
Klotho may play an inhibiting role in lipopolysaccharide-induced inflammation injury by inhibiting NF-kappaB (显示 NFKB1 蛋白) and Wnt (显示 WNT2 蛋白) signaling pathways in HK-2 (显示 HK2 蛋白) cells.
High klotho expression is associated with renal fibrosis and podocyte injuries.
Although our study revealed higher serum ET-1 (显示 EDN1 蛋白) and lower serum alpha-Klotho levels in systemic sclerosis patients compared to healthy controls, there were not any significant correlations between their serum levels with severity of organ involvement.
The A allele of the G395A polymorphism of Klotho, which emerges the higher levels of phosphate, may be associated with the risk of mortality in Iranian patients receiving hemodialysis.
shed alpha-klotho functions as an on-demand non-enzymatic scaffold protein (显示 HOMER1 蛋白) that promotes FGF23 (显示 FGF23 蛋白) signalling
Klotho has posed antioxidant and anti-apoptotic effects on oxidative injuries in TCMK-1 cells, which might be partially related to its inhibition of JNK (显示 MAPK8 蛋白)/MAPK (显示 MAPK1 蛋白) and p38/MAPK (显示 MAPK14 蛋白) phosphorylation and subsequent elevation of antioxidant enzymes. Increasing Klotho expression has played a protective role against oxidative stress in tubular epithelial cells.
Klotho expression in the central nervous system is associated with total antioxidant capacity in mice with experimental autoimmune encephalomyelitis.
Using mouse strains with parathyroid-specific deletions of Klotho and CaSR (显示 CASR 蛋白) and dual deletion of both genes, Klotho has a pivotal role in suppressing PTH (显示 PTH 蛋白) in the absence of CaSR (显示 CASR 蛋白). Chronic hypocalcemia and ex vivo PTG (显示 LPCAT3 蛋白) culture demonstrated an independent role for Klotho in mediating PTH (显示 PTH 蛋白) secretion.
DPP-4 (显示 DPP4 蛋白) inhibition with linagliptin slowed the progression of premature aging in klotho-/- mice. Provide a novel insight into the potential role of DPP-4 (显示 DPP4 蛋白) in the mechanism of premature aging.
Klotho protects tubular epithelial cells from renal ischemic-reperfusion injury and its anti-necroptotic role may be associated with oxidative stress inhibition.
studies uncover a novel hypomethylating character of Rhein in preventing Klotho loss and renal fibrosis, and demonstrate the efficacy of Klotho-targeted epigenetic intervention in potential treatment of renal fibrosis-associated kidney diseases.
the main physiological function of Klotho for mineral homeostasis in vivo is its role as co-receptor mediating Fgf23 (显示 FGF23 蛋白) action.
Findings establish a key role of osteocyte-expressed Klotho in regulating bone metabolism and indicate a new mechanism by which osteocytes control bone formation.
Selective HDAC3 (显示 HDAC3 蛋白) inhibition effectively alleviated Klotho loss and kidney injury, whereas the protective effects were largely abolished when Klotho was knocked down by siRNA, suggesting that aberrant HDAC3 (显示 HDAC3 蛋白) and Klotho loss are crucial components involved in the renal damage of mice with chronic kidney disease.
data showed that Klotho protects Tac (显示 IL2RA 蛋白)-induced oxidative stress by negatively regulating the PI3K/AKT (显示 AKT1 蛋白) pathway and subsequently enhancing FoxO3a (显示 FOXO3 蛋白)-mediated MnSOD (显示 SOD2 蛋白) expression.
Activated HAT activity of p300 (显示 EP300 蛋白) modulates AV calcification through osteogenic transdifferentiation of VICs with Klotho modulation.
Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (显示 GRK4 蛋白)-RUNX2 (显示 RUNX2 蛋白) pathway.
significant expression of FGF23 (显示 FGF23 蛋白) and KL within the growth plate and adjacent tissues imply a potential local role of FGF23 (显示 FGF23 蛋白) in chondrocyte differentiation and tissue mineralization.
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.
secreted form of Klotho protein