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Human Monoclonal EIF2C4 Primary Antibody for IP, WB - ABIN2668228
Azuma-Mukai, Oguri, Mituyama, Qian, Asai, Siomi, Siomi: Characterization of endogenous human Argonautes and their miRNA partners in RNA silencing. in Proceedings of the National Academy of Sciences of the United States of America 2008
DDB2 forms a complex with ROS1 and AGO4 and that they act at the ROS1 locus to modulate levels of DNA methylation and therefore ROS1 expression. DDB2 acts as a critical regulator of ROS1-mediated active DNA demethylation.
These results indicate an important role for AGO4 in targeting plant RNA viruses as well as demonstrating novel mechanisms of regulation of and by AGO4, independent of its canonical role in regulating gene expression by RNA-dependent DNA methylation (显示 HELLS 抗体) (RdDM).
Data suggest that AGO4-dependent siRNAs are secondary siRNAs dependent on the prior activity of the RdDM pathway at certain loci.
demonstrate that Pol V lncRNAs or the act of their transcription are required to lock Pol V holoenzyme into a stable DNA-bound state that allows AGO4 recruitment via redundant glycine-tryptophan/tryptophan-glycine AGO hook motifs present on both Pol V and its associated factor, SPT5L.
Findings reported here highlight an involvement of AGO4 during meiosis by ensuring accurate chromosome segregation at anaphase I.
Members of the AGO4 clade cooperatively participate in preventing the abnormal specification of multiple premeiotic gametophytic precursors during early ovule development.
Our results indicate that AtMBD6 is involved in RNA-mediated gene silencing and it binds to RNA binding proteins like AtRPS2C, AtAGO4 and AtNTF2. AtMBD6 also interacts with histone deacetylase AtHDA6 (显示 HDAC6 抗体) that might have a role in chromatin condensation at the targets of RdDM
These findings suggest that the targets of AGO4-directed RNA-directed DNA methylation (显示 HELLS 抗体) are regulatory units responsible for controlling gene expression under specific environmental conditions.
AGO4 and AGO6 mainly act sequentially in mediating small RNA-directed DNA methylation (显示 HELLS 抗体).
Trans-acting small interfering RNAs are associated with AGO4 proteins to direct DNA methylation (显示 HELLS 抗体).
Chimeras with Ago4 N-terminal domains were defective in RISC (显示 SCPEP1 抗体) activation & sometimes also in RNA loading. This highlights the pleiotropic role of the Ago N domain & emphasizes the unique position of human Ago4 within the Ago protein family.
EIF2C2 (显示 EIF2C2 抗体)-4 and PIWIL4 (显示 PIWIL4 抗体) appear increased in advanced tumors with distant metastasis, suggesting they may promote tumor invasion
The specificity of RNA interference depends on the concentration of Ago1 (显示 EIF2C1 抗体), Ago3 (显示 EIF2C3 抗体), and Ago4 relative to Ago2 (显示 EIF2C2 抗体).
EIF2C4 protein is expressed in differentiating and terminally differentiated N-type cells more than in S- and I-type cells
up-regulated in murine macrophage RAW264.7 cells transfected by Echinococcus multilocularis miR (显示 MLXIP 抗体)-71
show that Ago4(-/-) spermatogonia initiate meiosis early, resulting from premature induction of retinoic acid-response genes
Data show that Ago4- Ago1 (显示 EIF2C1 抗体)-Ago3 (显示 EIF2C3 抗体) genes are linked together at the p12 (显示 SPRN 抗体) of the chromosome 6, while Ago2 (显示 EIF2C2 抗体) is located at the p15 (显示 CDKN2B 抗体) of the chromosome 4.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1.
eukaryotic translation initiation factor 2C, 4
, argonaute 4
, protein argonaute-4
, eIF-2C 4
, eIF2C 4
, Piwi/Argonaute family protein meIF2C4
, argonaute RISC catalytic component 4