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Human Polyclonal YOD1 Primary Antibody for IF, IHC (p) - ABIN655251
Ernst, Mueller, Ploegh, Schlieker: The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. in Molecular cell 2009
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Mechanistically, YOD1 deubiquitinates ITCH, an E3 ligase of LATS (显示 LATS1 抗体), and enhances the stability of ITCH, which leads to reduced levels of LATS (显示 LATS1 抗体) and a subsequent increase in the YAP (显示 YAP1 抗体)/TAZ (显示 TAZ 抗体) level.
Data suggest that YOD1 is a novel regulator of the Hippo pathway, and thereby a potential therapeutic target for liver cancer.
These data define that YOD1 antagonizes TRAF6 (显示 TRAF6 抗体)/p62 (显示 GTF2H1 抗体)-dependent IL-1 (显示 IL1A 抗体) signaling to NF-kappaB (显示 NFKB1 抗体).
Upon damage, p97 (显示 EIF4G2 抗体) translocates to lysosomes and there cooperates with a distinct set of cofactors including UBXD1 (显示 UBXN6 抗体), PLAA (显示 PLAA 抗体), and the deubiquitinating enzyme YOD1, which we term ELDR components for Endo-Lysosomal Damage Response.
activity of the p97 (显示 EIF4G2 抗体)-associated deubiquitinylase YOD1 is also required for substrate disposal
miR (显示 MLXIP 抗体)-373 increases proliferation by directly targeting YOD1 in cervical cancer.
The assignment of a p97 (显示 EIF4G2 抗体)-associated ubiquitin processing function to YOD1 adds to our understanding of p97 (显示 EIF4G2 抗体)'s role in the dislocation of misfolded proteins from the endoplasmic reticulum.
Antigen presenting cells (APCs (显示 APCS 抗体)) that express a catalytically inactive version of the deubiquitylase YOD1 (YOD1-C160S) present exogenous antigens more efficiently to CD8 (显示 CD8A 抗体)(+) T cells, both in vitro and in vivo.
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. The protein encoded by this gene belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain. Alternative splicing results in multiple transcript variants.
, HIV-1-induced protease 7
, OTU domain containing 2
, OTU domain-containing protein 2
, YOD1 OTU deubiquinating enzyme 1 homolog ( yeast)
, ubiquitin thioesterase OTU1
, HIV-induced protein-7-like protease
, YOD1 OTU deubiquinating enzyme 1 homolog
, YOD1 OTU deubiquitinating enzyme 1 homologue