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APMCF1 may be the gene coding human signal recognition particle receptor beta and belongs to the small-G protein (显示 RAC2 蛋白) superfamily. Its strong expression pattern in colon cancer suggests it may play a role in colon cancer development.
APMCF1 participates at least partially in cell cycle regulation through regulating genes such as p21 (显示 CDKN1A 蛋白) and TIMP3 (显示 TIMP3 蛋白).
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.
signal recognition particle receptor subunit beta
, signal recognition particle receptor, beta subunit