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Results highlighted the essential roles played by GADD34 (显示 PPP1R15A 蛋白) and CReP in regulating mRNA translation during unstressed conditions and following endoplasmic reticulum stress.
CReP expression was markedly suppressed in XBP1 (显示 XBP1 蛋白)-deficient mice livers due to hyperactivated Ire1alpha (显示 ERN1 蛋白).
Ppp1r15a (显示 PPP1R15A 蛋白) mutant mice are superficially indistinguishable from wild type; Ppp1r15b(-/-) mouse embryos survive gestation but exhibit severe growth retardation and impaired erythropoiesis, and loss of both Ppp1r15 genes leads to early embryonic lethality
Whole-exome sequencing identified a homozygous missense mutation, c.1972G>A; p.Arg658Cys, in protein phosphatase 1 (显示 PPP1CB 蛋白), regulatory subunit 15b (PPP1R15B)
the first homozygous mutation in the PPP1R15B gene encoding the regulatory subunit of an eIF2alpha (显示 EIF2A 蛋白)-specific phosphatase in two siblings affected by a novel syndrome of diabetes of youth with short stature, intellectual disability, and microcephaly
CIP2A (显示 KIAA1524 蛋白) regulates cancer metabolism and CREB (显示 CREB1 蛋白) phosphorylation in non-small cell lung cancer
the mammalian traffic machinery co-opts p-eIF2alpha (显示 EIF2A 蛋白) and CReP, regulators of translation initiation.
PPP1R15B promotes dephosphorylation of the transcription initiation factor EIF2-alpha (EIF2S1\; MIM 603907) through recruitment of protein phosphatase-1 (PP1) catalytic subunits (see MIM 176875) (Harding et al., 2009
constitutive repressor of eIF2alpha phosphorylation
, protein phosphatase 1 regulatory subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15B
, protein phosphatase 1, regulatory (inhibitor) subunit 15b