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Human CTH Protein expressed in Wheat germ - ABIN1350649
Baskar, Li, Moore: Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
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We also performed SNP analysis of H2S synthesizing enzymes and found a significant increase in cystathionine gamma-lyase (CTH) 1364G-T allele frequency in patients with cardiovascular disease compared to controls
CSE is expressed in intraplaque microvessels, and H2S is a stimulator of micro-angiogenesis in vitro. Due to this pro-angiogenic effect, high levels of CSE in atherosclerotic plaques may be a potential risk for plaque vulnerability.
Study demonstrated that lower abundance of cystathionine gamma-lyase expression and H2S production enhances type-2 immunoreaction and renders a higher incidence of allergic asthma at a young age.
MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine gamma-lyase in THP-1 macrophages
not upregulated in uterine artery endothelium and smooth muscle in estrogen-dominant physiological states
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.
Lipopolysaccharide increases the expression of CSE in human macrophages, increasing H2S synthesis, via ERK/NF-kappaB pathway.
Nox4 is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE/H2S system is regulated by miR-216a, and regulates ABCA1-mediated cholesterol efflux and cholesterol levels through the PI3K/AKT pathway.
Collectively, our findings indicate that radiation could promote HCC cell invasion through EMT mediated by endogenous H2S/CSE signaling via the p38MAPK pathway.
3-Mercaptopyruvate sulphurtransferase and not cystathionine gamma-lyase is the primary regulator of coronary artery hydrogen sulfide production and function.
An increase of placental mRNA levels in the pre-eclampsia group was observed for methionine synthase and cystathionine gamma-lyase.
GPBAR1 plays a role in secondary bile acid induced vasodilation via reglation of cystathionine gamma-lyase. The GPBAR1/CSE pathway might contribute to endothelial dysfunction and hyperdynamic circulation in liver cirrhosis.
The miR-30 family are potentially important regulators of cystathionine gamma-lyase gene expression.
The l-cysteine/cystathionine gamma lyase/hydrogen sulfide pathway is involved in melanoma progression.
Substantial portion of Huntington's disease neurotoxicity appears to be attributable to cystathionine gamma-lyase deficiency.
CTH is distributed in the human fallopian tube epithelium.
Wnt pathway regulates CSE gene expression on transcriptional level and CSE/hydrogen sulfide plays important roles in colon cancer.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
Cystathionine gamma lyase-H2S was a dominant H2S generating system in osteoclasts, while cystathionine beta-synthase did not generate H2S.
ZYZ-803 stimulated the expression of cystathionine gamma-lyase (CSE) for H2S generation and the activity of endothelial NO synthase (eNOS) for NO production.Blocking CSE and/or eNOS suppressed ZYZ-803-induced H2S and NO production and cardioprotection.
Golgi stress response elicited by monensin stimulates CSE by acting via ATF4 with characteristics distinguishable from the endoplasmic reticulum stress response
The results of this study show that deletion of the cystathionine-gamma-lyase gene has no effects on hypoxia-induced changes in TASK K(+) channel activity.
CSE is critical for the progression of kidney fibrosis.
renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection
This study suggests that the CSE/H2S system is involved in the pathogenesis of obesity in mice.
Data show that CSE plays an important role as an inhibitor of inflammation in the liver by producing H2S from L-cysteine.
Study shows maintaining CSE expression is critically important for stress adaptation during posttraumatic acute lung injury and CS-induced COPD, most likely in a gender-dependent manner.
CSE-derived H2S contributes to mouse uterus homeostasis. Sildenafil reduces uterus contractility and its effect involves CSE-derived H2S.
The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S
Cystathionine-Gamma-Lyase Gene Deletion is associated with reduced inflammation and liver damage.
this study reveals the molecular basis for the differential expression of Cth in mouse models of essential hypertension under basal and pathophysiological conditions.
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE slightly ameliorates the outcome of LPS-induced endotoxemia in vivo.
lung MPO activity increased following induction of sepsis with CLP while siRNA treatment significantly reduced MPO activity. Liver and lung cytokine and chemokine levels in CLP-induced sepsis reduced following treatment with siRNA. These findings show a crucial pro-inflammatory role for H2S synthesized by CSE in macrophages in sepsis and suggest CSE gene silencing with siRNA as a potential therapeutic approach for this co
H2S augmented the S-sulfhydration of the rate-limiting gluconeogenic enzymes and PGC-1alpha and increased their activities, which were lower in untreated : To investigate the regulation of hepatic glucose production by cystathionine gamma-lyase KO hepatocytes
Endogenous cystathionine gamma-lyase/Hydrogen sulfide regulates ischaemic vascular remodelling mediated during hind limb ischaemia through NO-dependent monocyte recruitment
The results of this study suggest that CSE is not critically involved in chronic pain signaling in mice and that sources different from CSE mediate the pain relevant effects of H2S.
CSE-H2S increased PPARgamma activity by direct sulfhydration at the C139 site, thereby changing glucose into triglyceride storage in adipocytes.
Therefore, our data suggest that DNA hypermethylation of CpG rich region in cse promoter might contribute to the decrease of cse transcription and H2S production in macrophages, and thus contribute to atherosclerosis development.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen