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Human CTH Protein expressed in Wheat germ - ABIN1350649
Baskar, Li, Moore: Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006
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We also performed SNP analysis of H2S synthesizing enzymes and found a significant increase in cystathionine gamma-lyase (CTH) 1364G-T allele frequency in patients with cardiovascular disease compared to controls
CSE is expressed in intraplaque microvessels, and H2S is a stimulator of micro-angiogenesis in vitro. Due to this pro-angiogenic effect, high levels of CSE in atherosclerotic plaques may be a potential risk for plaque vulnerability.
Study demonstrated that lower abundance of cystathionine gamma-lyase expression and H2S production enhances type-2 immunoreaction and renders a higher incidence of allergic asthma at a young age.
MicroRNA-186 promotes macrophage lipid accumulation and pro-inflammatory cytokine secretion by targeting cystathionine gamma-lyase in THP-1 macrophages
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
ur findings suggest that these two families of amines inhibit cystathionine-gamma-lyase (CSE) to varying extents, which directly results in altered levels of intracellular HCY and consequent changes in Human vascular smooth muscle cells proliferation.
Lipopolysaccharide increases the expression of CSE in human macrophages, increasing H2S synthesis, via ERK (显示 EPHB2 蛋白)/NF-kappaB (显示 NFKB1 蛋白) pathway.
Nox4 (显示 NOX4 蛋白) is a positive transcriptional regulator of cystathionine-gamma-lyase in endothelial cells.
The expression of CSE was positively correlated with the severity of gastric ulcer
Our study demonstrates that CSE/H2S system is regulated by miR (显示 MLXIP 蛋白)-216a, and regulates ABCA1 (显示 ABCA1 蛋白)-mediated cholesterol efflux and cholesterol levels through the PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) pathway.
Exogenous administration of CO exacerbated allergic symptoms, resulting in higher levels of both CO and heme oxygenase-1 expression, and a further reduction in H2S levels and CSE expression.
Cystathionine gamma lyase-H2S was a dominant H2S generating system in osteoclasts, while cystathionine beta-synthase (显示 CBS 蛋白) did not generate H2S.
ZYZ-803 stimulated the expression of cystathionine gamma-lyase (CSE) for H2S generation and the activity of endothelial NO synthase (eNOS (显示 NOS3 蛋白)) for NO production.Blocking CSE and/or eNOS (显示 NOS3 蛋白) suppressed ZYZ-803-induced H2S and NO production and cardioprotection.
Golgi stress response elicited by monensin stimulates CSE by acting via ATF4 (显示 ATF4 蛋白) with characteristics distinguishable from the endoplasmic reticulum stress response
The results of this study show that deletion of the cystathionine-gamma-lyase gene has no effects on hypoxia-induced changes in TASK K(+) channel (显示 KCNC4 蛋白) activity.
CSE is critical for the progression of kidney fibrosis.
renal expression of CTH and other H2S-producing enzymes was markedly suppressed after IRI, which could be an integrated adaptive response for renal cell protection
This study suggests that the CSE/H2S system is involved in the pathogenesis of obesity in mice.
Data show that CSE plays an important role as an inhibitor of inflammation in the liver by producing H2S from L-cysteine.
Study shows maintaining CSE expression is critically important for stress adaptation during posttraumatic acute lung injury and CS-induced COPD (显示 ARCN1 蛋白), most likely in a gender-dependent manner.
CSE-derived H2S contributes to mouse uterus homeostasis. Sildenafil reduces uterus contractility and its effect involves CSE-derived H2S.
This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. Glutathione synthesis in the liver is dependent upon the availability of cysteine. Mutations in this gene cause cystathioninuria. Alternative splicing of this gene results in three transcript variants encoding different isoforms.
, cystathionase (cystathionine gamma-lyase)
, cysteine desulfhydrase
, cysteine-protein sulfhydrase
, homoserine deaminase
, homoserine dehydratase
, CTL target antigen
, probasin-related antigen