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抗Human AMFR 抗体:
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抗Rat (Rattus) AMFR 抗体:
Human Polyclonal AMFR Primary Antibody for Func, IHC - ABIN4280243
Lucarelli, Galleggiante, Rutigliano, Sanguedolce, Cagiano, Bufo, Lastilla, Maiorano, Ribatti, Giglio, Serino, Vavallo, Bettocchi, Selvaggi, Battaglia, Ditonno: Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma. in Oncotarget 2015
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Human Polyclonal AMFR Primary Antibody for IHC - ABIN965545
Shimizu, Tani, Watanabe, Nagamachi, Niinaka, Shiroishi, Ohwada, Raz, Yokota: The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. in FEBS letters 1999
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Human Polyclonal AMFR Primary Antibody for FACS, IHC (p) - ABIN388938
Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. in Biochemical and biophysical research communications 1995
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This is the first study to show that HSPA1L (显示 HSPA1L 抗体) mediated HIF-1alpha (显示 HIF1A 抗体) stabilization. In addition, this is the first study to show that GP78 inactivation promotes cancer cell proliferation, migration and eventual tumor growth both in vivo and in vitro by increasing cellular prion protein (显示 PRNP 抗体).
overexpression of gp78 or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (显示 SERPINA1 抗体) deficiency
Despite its interaction with gp78, Lnp does not seem to have a broad function in degradation of misfolded ER proteins.
Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin (显示 UBB 抗体) chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin (显示 UBB 抗体) chains.
AMFR expression is significantly reduced in plasma from osteoporosis patients.
Catalytic inactivation of MGRN1 (显示 MGRN1 抗体) results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy.
Authors conclude that the Hrd1 (显示 SYVN1 抗体) complex forms an essential retrotranslocation module that is evolutionarily conserved, but the mammalian ERAD system uses additional ubiquitin ligases to assist Hrd1 (显示 SYVN1 抗体) during retrotranslocation.
Downregulation of AMFR induced cell cycle arrest at the G0/G1 phase, and increased apoptosis of the THP1 (显示 GLI2 抗体) cells.
The authors identify USP13 (显示 USP13 抗体) as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A (显示 UBL4A 抗体) to maintain the functionality of Bag6 (显示 BAT3 抗体).
Data show that autocrine motility factor receptor (AMFR) and NOTCH1 (显示 NOTCH1 抗体) protein are the direct target genes of microRNA miR (显示 MLXIP 抗体)-139-5p in colorectal cancer (CRC (显示 CALR 抗体)).
the role of gp78 and cidec (显示 CIDEC 抗体) in hepatic steatosis, were investigated.
Gp78, an E3 ubiquitin ligase (显示 MUL1 抗体) acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH (显示 SAMSN1 抗体)) and liver cancer.
The ubiquitin ligase (显示 RNF123 抗体) gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation.
we consistently observe involvement of gp78 in Insig-1 (显示 INSIG1 抗体) degradation, we find no substantive evidence to support roles for either gp78 or TRC8 (显示 RNF139 抗体) in the robust sterol-accelerated degradation of HMG-CoA reductase (显示 HMGCR 抗体)
Ablation of gp78 in liver improves hyperlipidemia and insulin (显示 INS 抗体) resistance by inhibiting SREBP to decrease lipid biosynthesis.
Palmitoylation of RING finger (显示 PCGF1 抗体) cysteines therefore regulates gp78 distribution to the peripheral ER
AMFR is involved in the process of learning and memory in the central nervous system.
KAI1 has a role in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase
Gp78 promotes SOD1 (显示 SOD1 抗体) and ataxin-3 (显示 ATXN3 抗体) degradation in endoplasmic reticulum.
cytoplasmic protein (显示 BLZF1 抗体) mouse p97 (显示 EIF4G2 抗体)(mp97) participates in the formation of a ternary complex containing mouse autocrine motility factor receptor (mAMFR), mp97, and peptide N-glycanase
gp78 plays a critical role in protecting against ER stress in liver
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.
E3 ubiquitin-protein ligase AMFR
, RING finger protein 45
, AMF receptor
, autocrine motility factor receptor
, autocrine motility factor receptor, amfr
, autocrine motility factor receptor amfr
, autocrine motility factor receptor, isoform 2-like