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pathogenic variants are described in four genes encoding components of the p120-catenin complex (CTNND1, PLEKHA7, PLEKHA5) and an epithelial splicing regulator (ESRP2), in addition to the known Cleft lip/Palate-associated gene, CDH1, which encodes E-cadherin.
CTNND1 binds to CDH1 and controls the stability of the complex.
miR-298 suppresses hepatocellular carcinoma progression at least partially by targeting CTNND1-mediated Wnt/beta-catenin signaling.
these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP protein level and thus facilitate BEAS-2B cell migration.
Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis.
Results provide evidence that 90K interacts with the E-cadherin-p120-catenin complex and induced its dissociation, altering the phosphorylation status of p120-catenin.
Results show that head and neck squamous cell carcinoma tumors with low P120CTN and PI3K pathway mutations have higher levels of MMP1 compared to tumors with high P120CTN and no PI3K pathway mutations demonstrating that P120CTN downregulation and PIK3CA mutations promote MMP1-driven invasion.
In 11 BCD patients from eight families, we identified five CDH1 deleterious missense mutations and three CTNND1 truncating mutations.
Our combined data indicate that as HPMECs achieve confluence and CD31 ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31, permitting NEU1-mediated desialylation of CD31.
Studied interactions between protein kinase C alpha (PKCalpha), FOXC2, and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha acts as an upstream regulator of FOXC2, which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Studied the association between genetic polymorphisms in the CTNND1 gene and risk of pancreatic carcinoma in Chinese population.
Results found that CTNND1 expression was significantly up-regulated in hepatocellular carcinoma (HCC) cancer lesions compared with paired normal liver tissues and, could promote cell proliferation, migration, and invasion in vitro and in vivo. The study provides evidence that CTNND1 functions as a novel tumor oncogene in HCC.
These results suggest that stabilization of delta-catenin by Hakai is dependent on Src.
These results uncover a new role for p120 catenin bound to the N-cadherin precursor ensuring its trafficking through the biosynthetic pathway towards the cell surface.
The BC cells showed the coexpression of E- and P-cadherins, as well as release of the molecules b- and p120-catenins into the cytoplasm of tumor cells, which leads to the activation of intracellular mechanisms for changing the structure of the cytoskeleton and the level of proliferation
recent results describing actions of p120-catenin in different phases of this pathway
The mTOR-dependent, epithelial phenotype of TSC astrocytes suggests TSC1/2 and mTOR tune the phosphorylation level of catenin delta-1 by controlling PKCe activity, thereby regulating the mesenchymal-epithelial-transition (MET)
Src-dependent phosphorylation of p120(ctn) can respond rapidly to negative pressure and contribute to E-cadherin downregulation.
p120 participates in the progress of gastric cancer through regulating Rac1 and Pak1.
The overexpression of P120ctn led to a decrease in both invasion and migration capacity of HN12 cells accompanied by a decrease in EMT markers. Knockdown of P120ctn led to an increase in both invasion and migration capacity accompanied by an increase in EMT markers.
over-expression of P120-catenin suppressed NF-kappaB signaling and reversed the inflammatory effects. P120-catenin prevents endplate chondrocytes from undergoing ICMT-mediated inflammation by suppressing the expression of NF-kappaB.
Stretch induced p120 degradation and the endocytosis of E-cadherin, which induced beta-catenin translocation into the nucleus, a key event in lung injury progress and repair.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin, but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso-dependent expression of Wnt11, is reported.
Delta-catenin activates Rac1 and Cdc42 but inhibits RhoA in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
p120-RhoA-GTPase-mediated signaling can differentially regulate the migratory behavior of epidermal cells, which has potential implications for chronic wound responses and cancer.
p120 functions as a differential regulator of TLR4 signaling pathways by facilitating TLR4 endocytic trafficking in macrophages, and support a novel role for p120 in influencing the macrophages in the lung inflammatory response to endotoxin.
Shroom3 has a role in apical constriction during lens pit morphogenesis and is recruited in a pathway involving p120-catenin
The recruitment of M-cadherin to lipid rafts during pre-fusion myogenesis events depended on interaction with p120 catenin, whereas the organization of microrafts was controlled by a small G protein, Rac1.
ZBTB33 expression may elicit intestinal inflammation by antagonizing p120ctn function.
delta-catenin plays a key role in molecular processes underlying learning and memory: dynamic palmitoylation of delta-catenin can coordinate activity-dependent changes in synapse adhesion and structure and the efficacy of synaptic transmission.
Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium.
we show that somatic loss of p120-catenin (p120) in a conditional mouse model of noninvasive mammary carcinoma results in formation of stromal-dense tumors that resemble human metaplastic breast cancer and metastasize to lungs and lymph nodes
mXinalpha directly interacts with p120-catenin and suppresses the p120-catenin-induced branching phenotype.
Phosphoinositide 3-kinase and Rac polarization depend specifically on the N-cadherin-p120 catenin complex, whereas myosin II light chain and actin filament polarization depend on the N-cadherin-beta-catenin complex.
Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2.
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (and canonical Wnt) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin.
delta-catenin has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like