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these data indicated under cigarette smoke condensate treatment; losing of membrane p120ctn could upregulate surface NEP (显示 MME 蛋白) protein level and thus facilitate BEAS-2B cell migration.
Data show that p120-catenin interacts with kinesin family member 23 (MKLP1) to regulate focused rhoA GTP-binding protein (RhoA) activity during cytokinesis.
Results provide evidence that 90K interacts with the E-cadherin (显示 CDH1 蛋白)-p120-catenin complex and induced its dissociation, altering the phosphorylation status of p120-catenin.
Results show that head and neck squamous cell carcinoma tumors with low P120CTN and PI3K (显示 PIK3CA 蛋白) pathway mutations have higher levels of MMP1 (显示 MMP1 蛋白) compared to tumors with high P120CTN and no PI3K (显示 PIK3CA 蛋白) pathway mutations demonstrating that P120CTN downregulation and PIK3CA (显示 PIK3CA 蛋白) mutations promote MMP1 (显示 MMP1 蛋白)-driven invasion.
In 11 BCD (显示 CYP4V2 蛋白) patients from eight families, we identified five CDH1 (显示 CDH1 蛋白) deleterious missense mutations and three CTNND1 truncating mutations.
Our combined data indicate that as HPMECs achieve confluence and CD31 (显示 HBA1 蛋白) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 (显示 NEU1 蛋白) to CD31 (显示 HBA1 蛋白), permitting NEU1 (显示 NEU1 蛋白)-mediated desialylation of CD31 (显示 HBA1 蛋白).
Studied interactions between protein kinase C alpha (PKCalpha (显示 PKCa 蛋白)), FOXC2 (显示 FOXC2 蛋白), and p120-catenin (CTNND1) in breast cancer, cell migration/ invasion; found PKCalpha (显示 PKCa 蛋白) acts as an upstream regulator of FOXC2 (显示 FOXC2 蛋白), which in turn represses the expression of p120-catenin, in both in endocrine resistant ER+breast cancer and basal A triple negative breast cancer
Studied the association between genetic polymorphisms in the CTNND1 gene and risk of pancreatic carcinoma in Chinese population.
Results found that CTNND1 expression was significantly up-regulated in hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) cancer lesions compared with paired normal liver tissues and, could promote cell proliferation, migration, and invasion in vitro and in vivo. The study provides evidence that CTNND1 functions as a novel tumor oncogene (显示 RAB1A 蛋白) in HCC (显示 FAM126A 蛋白).
These results suggest that stabilization of delta-catenin (显示 CTNND2 蛋白) by Hakai (显示 CBLL1 蛋白) is dependent on Src (显示 SRC 蛋白).
over-expression of P120-catenin suppressed NF-kappaB (显示 NFKB1 蛋白) signaling and reversed the inflammatory effects. P120-catenin prevents endplate chondrocytes from undergoing ICMT (显示 ICMT 蛋白)-mediated inflammation by suppressing the expression of NF-kappaB (显示 NFKB1 蛋白).
Stretch induced p120 degradation and the endocytosis of E-cadherin (显示 CDH1 蛋白), which induced beta-catenin (显示 CTNNB1 蛋白) translocation into the nucleus, a key event in lung injury progress and repair.
p120 Catenin underexpression is associated with Invasive Pancreatic Neoplasia.
We conclude that p120ctn is not only an adaptor and regulator of E-cadherin (显示 CDH1 蛋白), but is also indispensable for proper lineage commitment
p120 is required for dietary calcium suppression of oral carcinogenesis.
p120ctn has a critical role in biliary differentiation and is a potent suppressor of liver tumor growth.
a mechanistic link between E-cadherin (显示 CDH1 蛋白) loss and subsequent control of Rho-driven anoikis resistance through p120- and Kaiso (显示 ZBTB33 蛋白)-dependent expression of Wnt11 (显示 WNT11 蛋白), is reported.
Delta-catenin (显示 CTNND2 蛋白) activates Rac1 and Cdc42 (显示 CDC42 蛋白) but inhibits RhoA (显示 RHOA 蛋白) in lymphatic endothelial cells.
p120-catenin regulates REST and CoREST (显示 Rcor2 蛋白) and modulates mouse embryonic stem cell differentiation.
Data indicate that p120 catenin is required for proper pancreatic tubulogenesis and branching morphogenesis.
Upregulation of Rac1 activity by Wnt3a temporally correlated with enhanced p120-catenin binding to Rac1 and Vav2.
p120ctn signaling in motor neurons promotes nerve-muscle interaction and neuromuscular junction assembly
Dyrk1A (显示 DYRK1A 蛋白) positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (显示 ZBTB33 蛋白) (and canonical Wnt (显示 WNT2 蛋白)) gene targets such as siamois and wnt11.
The degradation machinery of the canonical Wnt (显示 WNT2 蛋白) pathway modulates p120-catenin protein stability through mechanisms shared with those regulating beta-catenin (显示 CTNNB1 蛋白).
delta-catenin (显示 CTNND2 蛋白) has an essential role in amphibian development, and has functional links to cadherins and Rho-family GTPases
This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene.
cadherin-associated Src substrate
, catenin delta-1
, p120 catenin
, catenin src
, catenin (cadherin-associated protein), delta 1
, catenin delta-1 isoform 1AC
, catenin, delta 1
, catenin delta-1-like