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抗Human Adenosine a1 Receptor 抗体:
抗Mouse (Murine) Adenosine a1 Receptor 抗体:
抗Rat (Rattus) Adenosine a1 Receptor 抗体:
Human Polyclonal Adenosine a1 Receptor Primary Antibody for FACS, ICC - ABIN4278349
Yu, Zacharia, Jackson, Apodaca: Adenosine receptor expression and function in bladder uroepithelium. in American journal of physiology. Cell physiology 2006
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Human Polyclonal Adenosine a1 Receptor Primary Antibody for WB - ABIN611319
Bowery, Brown: The cloning of GABA(B) receptors. in Nature 1997
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Human Polyclonal Adenosine a1 Receptor Primary Antibody for IF (p), IHC (p) - ABIN719396
Cao, Dai, Wei, Han, Guan, Li, Liu, Xiao, Li: Effects of cordycepin on spontaneous alternation behavior and adenosine receptors expression in hippocampus. in Physiology & behavior 2017
Cow (Bovine) Polyclonal Adenosine a1 Receptor Primary Antibody for ELISA - ABIN314251
Funakoshi, Chan, Good, Libonati, Piuhola, Chen, MacDonnell, Lee, Herrmann, Zhang, Martini, Palmer, Sanbe, Robbins, Houser, Koch, Feldman: Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. in Circulation 2006
Data suggest that activation of adenosine A1 receptors elicit receptor-operated Ca(2+) entry in porcine afferent arterioles, the level of which is dependent on postnatal maturation of TRPC3 channels.
mRNA for adenosine A(1), A(2A), A(2B), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Selective activation of A(1), A(2A), or A(3) adenosine receptors provides significant protection against lung ischemia-reperfusion injury.
3.6 A structure of the human A1R in complex with adenosine and heterotrimeric Gi2 protein determined by Volta phase plate cryo-electron microscopy
ADORA1 is not a common risk factor or causal gene for Parkinson's disease or dementia with Lewy bodies in the European population
monocyte-derived macrophages from ankylosing spondylitis patients expressed increased levels of A2AAR and reduced levels of A1 and A2BAR compared to healthy controls
studies revealed individual trait characteristics for being either vulnerable or resilient to both alcohol and to sleep deprivation. Both interventions induce gradual increases in cerebral A1AR availability, pointing to a potential common molecular response mechanism.
Data suggested that adenosine A1 receptor might potentiate glycinergic transmission through Galphai/PKA/alpha3 and Gbetagamma/alpha1ins pathways in inflamed rat.
Elevated A1 adenosine receptor is associated with sleep deprivation.
Mutation in ADORA1 may be associated with early-onset parkinsonism and cognitive dysfunction.
Inhibition of cholinergic neurotransmission by beta3-adrenoceptors results from adenosine release via equilibrative nucleoside transporters and prejunctional A1-receptor stimulation in urinary bladder.
This study showed that increased neuronal A1R expression in Rasmussen Encephalitis may be involved in prevention of seizures spread and seizures-induced damage, limitation of both seizures and inflammation atrophy in 1 cerebral hemisphere.
A1R signaling enhances A2AR-mediated neurodegeneration [review]
Mutational and computational analysis of A1-AR revealed a distinct conformation of the second extracellular loop and a wider extracellular cavity with a secondary binding pocket that can accommodate orthosteric and allosteric ligands.
second extracellular loop is a key allosteric ligand-binding determinant.
this study highlights a key role for extracellular loop 2 in A1AR orthosteric ligand binding and receptor activation.
Dysregulation in ADORA1/ADORA2A expression was associated with glioma development.
A1R mRNA levels and A1R density in PBMCs from idiopathic normal-pressure hydrocephalus patients were significantly lower than control subjects
Its central activation could be and approach to achieving a shifted homeostasis in which physiology is downregulated to a homeostatically-regulated, stable hypometabolic state. (review)
In postmortem human prefrontal cortex, adenosine A1 receptor is coupled preferentially, if not exclusively, to Galphai-3.
Results show that ADORA1 rs2228079 and ADORA2A rs5751876 polymorphisms are associated with the risk of Gilles de la Tourette Syndrome, co-morbid disorders, and may affect the age of tics onset in Polish population.
It has the intrinsic ability to form a heteromeric complex with metabotropic glutamate receptor type 1 and mutually modulate signaling.
Paeoniflorin promotes the survival of cultured cortical neurons by increasing Akt and ERK1/2 phosphorylation via A1R-mediated transactivation of EGFR.
Hypothalamic expression of A1R, are increased in the diet-induced obesity mouse model.
Loss of A1AR expression results in an increased susceptibility to noise-induced cochlear neural injury and hearing loss.
Expression of the SENP2 gene was suppressed by theobromine. In vivo knockdown studies showed that AR1 knockdown in mice attenuated the anti-adipogenic effects of theobromine in younger mice. Theobromine suppresses adipocyte differentiation and induced C/EBPbeta degradation by increasing its sumoylation.
The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.
Systemic inflammatory response syndrome-associated lymphopenia is initiated by A1R desensitization and adenosine-mediated inhibition of IL-15 production is part of the mechanism that accounts for the delay in leukopenia recovery in patients with severe sepsis.
Results demonstrated a significant downregulation of adenosine A1 receptors in the cortex and striatum, concomitant to striatal D2R downregulation in iron deficient mice and rats.
Adenosine A1A receptor and adenosine A3A receptor agonists and adenosine 5'-monophosphate cause regulated hypothermia that was characterized by a drop in total energy expenditure, physical inactivity, and preference for cooler environmental temperatures, indicating a reduced body temperature set point.
over-expression of sEH enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs. These results suggest a possible interaction between sEH, A1AR, and KATP channels in regulating vascular tone.
Results indicate that the adenosine A1 receptor is an important molecular component mediating hypoxic depression in adult mice and it appears to stabilize respiration of neonatal mice
The findings of this study implicated a glial-neuronal circuit, mediated by Ado, neuronal AdoRA1, and glial AdK that can modulate sleep homeostasis in a manner influenced by glial metabolic state.
Chronic cerebral ischemia in a mouse model induced down-regulation of adenosine A1 receptors.
Activation of A3, A2A and A1 Adenosine Receptors in CD73-Knockout Mice Affects B16F10 Melanoma Growth, Neovascularization, Angiogenesis and Macrophage Infiltration
A1 receptors regulate metabolism and islet endocrine and vascular functions during ageing
Adenosine A1 receptor knockout mice displayed increased depressive-like behavior.
data support the interpretation that adenosine A receptors localized to the pontine reticular formation significantly alter nociception.
did not identify phenotypic modifications of A1AR-related effects on blood pressure, heart rate and plasma renin by differences in genetic background
Interaction between angiotensin II and adenosine in VSMC normally involves A1 receptor signalling
Extracellular cAMP, through its metabolite adenosine, reduced cardiomyocyte cAMP formation and hypertrophy by activating A1 adenosine receptors while delivering an antifibrotic signal to cardiac fibroblasts by A2 adenosine receptor activation.
NPS evokes central antinociceptive effects by activating both A1 and A2A receptors during phase 1, but only the adenosine A2A receptor during phase 2 of the formalin test
These findings indicate that adenosine activation of leukocyte adenosine A1 receptor plays a significant role in their recruitment to the infected lung and contributes to influenza pathogenesis.
Data suggest that that ADORA1 forms homomers/homodimers in brain cortex.
Adenosine A1 receptors promote vasa vasorum endothelial cell barrier integrity via Gi and Akt-dependent actin cytoskeleton remodeling.
It is reasonable to assume that the moderate decrease in affinity of the guinea pig atrial A1 receptor is only in part responsible for the diminished A1 receptor-mediated effect in hyperthyroidism.
The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene.
adenosine A1 receptor
, A1 adenosine receptor
, adenosine receptor A1