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ADCY9 immunoreactivity score was significantly higher (P=0.002) in tumor tissues (6.40+/-1.26, n=200) than in adjacent normal samples (4.13+/-0.83, n=8). The IRS (显示 IARS 蛋白) and mRNA expression of ADCY9 were correlated to colon cancer TNM (显示 ODZ1 蛋白) staging.
polymorphisms in the ADCY9 gene are significantly associated with asthma and/or allergy markers
The stronger TNF-alpha (显示 TNF 蛋白) responses in young males compared to females may be partly associated with male-specific down-regulation of ADCY7 (显示 Adcy7 蛋白) and ADCY9.
The effects of dalcetrapib on atherosclerotic outcomes are determined by correlated polymorphisms in the ADCY9 gene.
The importance of miR (显示 MLXIP 蛋白)-181a-mediated AC9 downregulation in acute promyelocytic leukemia (显示 PML 蛋白), is reported.
Data indicate that adenylyl cyclase 9 (AC9) transcript is a direct target of miR (显示 MLXIP 蛋白)-181b.
in heart, Yotiao brings together PKA, PP1 (显示 PPA1 蛋白), PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
The HIV-1 regulatory protein Tat (显示 TAT 蛋白) was shown to inhibit the activity of adenylyl cyclase in rat microglial cells.
blocking glycosylation of AC9 significantly attenuates Galpha (显示 SUCLG1 蛋白)(s) stimulation.
in heart, Yotiao brings together PKA, PP1 (显示 PPP1CC 蛋白), PDE4D3, AC9, and the I(Ks) channel to achieve localized temporal regulation of beta-adrenergic stimulation.
miR (显示 MLXIP 蛋白)-142-3p regulates the production of cAMP by targeting adenylyl cyclase (AC) 9 messenger RNA in CD4 (显示 CD4 蛋白)(+)CD25 (显示 IL2RA 蛋白)(-) T cells and CD4 (显示 CD4 蛋白)(+)CD25 (显示 IL2RA 蛋白)(+) T(REG (显示 KCNH2 蛋白)) cells.
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin.
ATP pyrophosphate-lyase 9
, adenylate cyclase type 9
, adenylate cyclase type IX
, adenylyl cyclase 9
, type IX ATP pyrophosphate-lyase
, adenylyl cyclase type 10
, adenylyl cyclase type IX
, adenylate cyclase 9
, adenylate cyclase type 9-like