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Human Polyclonal GBX2 Primary Antibody for IHC (p), IHC - ABIN188669
Burroughs-Garcia, Sittaramane, Chandrasekhar, Waters: Evolutionarily conserved function of Gbx2 in anterior hindbrain development. in Developmental dynamics : an official publication of the American Association of Anatomists 2011
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Dog (Canine) Polyclonal GBX2 Primary Antibody for ELISA, WB - ABIN547735
Palmqvist, Glover, Hsu, Lu, Bossen, Piret, Humphries, Helgason: Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency. in Stem cells (Dayton, Ohio) 2005
that gbx2 induction at 16h post-fertilization repressed the expression of emx3, dlx2a, and six3b in the ventral telencephalon
Gbx2 is expressed in neural crest cells and iridophores during development. Gbx2 knockdown leads to apoptosis of neural crest cells. The N-terminal domain of Gbx2 rescues the phenotype of Gbx2 knockdown.
gbx2 not only functions to position the midbrain-hindbrain boundary but also regulates neurogenesis in the anterior hindbrain.
Gbx2 functions as a transcriptional repressor to regulate the specification and morphogenesis of the mid-hindbrain junction in a dosage- and stage-dependent manner.
in the zebrafish gbx1 and gbx2 are required redundantly for morphogenesis of the cerebellar primordium and subsequent cerebellar differentiation, but that this requirement is alleviated by knocking down Otx
gbx2/Gbx2 has an evolutionarily conserved role in anterior hindbrain development.
Here we report the isolation, mapping, chromosomal synteny and spatiotemporal expression of gbx1 and gbx2 in zebrafish. We focus in particular on the expression of these genes during development of the midbrain-hindbrain territory.
Ectopic expression of gbx2 by mRNA injection caused cyclopia or truncation of the fore- and midbrain and severely affected isthmic and cerebellar structures.
gbx2 expression during the somitogenesis stage in zebrafish is regulated by a complex mechanism involving Pax2 as well as activators and suppressors in the regions flanking the gene.
The accession number for the cDNA listed for the sequence data at the bottom of page 335 on the left side is incorrect. It should read U31468 instead of U31458.
Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC).
Gbx2 and Otx2 interact with the WD40 domain of Groucho/Tle corepressors
Altered expression is associated with therapy failure and death in patients with multiple types of cancer.
Functional studies indicated that Klf4 mediates the self-renewal-promoting effects of Gbx2, because knockdown of Klf4 expression abrogated the ability of Gbx2 to maintain the undifferentiated state of mESCs.
Deregulated FGF8 and Otx2/Gbx2 gene expression underlies cerebellar vermis hypoplasia in mouse model of CHARGE syndrome.
Gbx2 is essential for the acquisition of the thalamic neuronal identity by repressing habenular identity through a feedback signaling from postmitotic neurons to progenitors
Results reveal a novel function of Gbx2 in mESC reprogramming and LIF/Stat3-mediated self-renewal.
Results indicate that the dynamic expression of Gbx2 may act as an important determinant in coupling with other developmental programs to generate distinct thalamic nuclei.
Identified are several GBX2 candidate target genes including ROBO1, PLXNA4, SLIT3, NRP1, PCDH15, USH2A, NOTCH2, and EEF1A1 that are likely to contribute many of the developmental defects observed in Gbx2 mutant organisms.
Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
the Gbx2 homeodomain recognizes the target TAATTA in the FM enhancer, and Gbx2 associates with the FM enhancer in the hindbrain
long-term lineage analysis reveals that the presence and timing of Gbx2 expression in interneuron progenitors results in the differential contribution to subtypes of terminally differentiated interneurons in the adult spinal cord
findings reveal the distinct function of Gbx2 and Fgf8 in a stepwise process in the development of the compartment boundary at the midbrain-hindbrain border
Gbx2 is required for the development of striatal cholinergic interneurons, perhaps by regulating tangential migration of the striatal cholinergic precursors.
Data suggest that the juxtaposition of the expression domains of Gbx2 and Otx2 within the mes/r1 area is essential for the maintenance of Fgf8 expression.
gbx-2 expression in zebrafish embryo
Gbx2 is required after embryonic day 9 (E9) to repress Otx2 in the cerebellar anlage and position the midbrain/hindbrain organizer
Sef and Sproutys function synergistically to regulate Gbx2 expression in the anterior hindbrain.
Gbx2 is required for development of rhombomeres 1-3, and also for normal gene expression in rhombomeres 4-6.
Gbx2 is required for the morphogenesis of the mouse inner ear: a downstream candidate of hindbrain signaling.
Loss of Gbx2 results in neural crest cell patterning and pharyngeal arch artery defects in the mouse embryo.
May act as a transcription factor for cell pluripotency and differentiation in the embryo.
homeobox protein GBX-2
, gastrulation brain homeobox 2
, gastrulation brain homeo box 2
, gastrulation and brain-specific homeobox protein 2
, stimulated by retinoic acid gene 7 protein
, homeobox protein Xgbx-2