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FOXA2 may act as a tumor suppressor and inhibit the epithelial-mesenchymal transition of endometrial cancer cells.
Our findings suggest that autophagy, through participation of FOXA2, maintains the characteristics of OCSCs. Autophagy and FOXA2 are therefore potential targets for ovarian cancer stem cell directed therapies.
MAPK (显示 MAPK1 蛋白) and FoxA2 mediate CS-induced squamous metaplasia. MAPK (显示 MAPK1 蛋白) inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia.
In conclusion, our data suggest that overexpression of the Hedgehog (显示 SHH 蛋白) components SHH (显示 SHH 蛋白), GLI2 and FOXA2 might be used as markers of an aggressive hemangioma.
Our results suggest that FoxA2 plays a key role in the expression of hepatic phenotype of AFP (显示 AFP 蛋白)-producing adenocarcinomas.
FOXA2 is a specific and sensitive molecular marker for small cell neuroendocrine carcinoma of the prostate.
HNF3beta plays a vital role in regulation of CPS1 (显示 CPS1 蛋白) gene and could promote the metabolism of ammonia by regulating CPS1 (显示 CPS1 蛋白) expression.
The c.505T>C, p.S169P genetic variant occurs at the conserved forkhead DNA binding domain of the FOXA2 and causes a rare and unique clinical phenotype of hypopituitarism, CHI, dysmorphic features, liver, pancreas, heart and gastrointestinal abnormalities.
Results showed that FOXA2 expression was decreased during Il-13 (显示 IL13 蛋白) induced goblet cell differentiation but DNA methylation (显示 HELLS 蛋白) of its promoter was not changed. In the absence of Il-13 (显示 IL13 蛋白), no difference was found for FOXA2 expression but hypomethylation of CpG # 10 and 11 in the its promoter was detected. These findings suggest that aberrant DNA methylation (显示 HELLS 蛋白) of FOXA2 is one of the factors underlying mucus hypersecretion in COPD (显示 ARCN1 蛋白).
the findings of the current study provide compelling genetic evidence that FOXA2 is a pathogenic driver gene in the etiology of primary uterine cancers, including uterine carcinosarcomas and carcinomas.
in FoxA2-FoxA3 (显示 FOXA3 蛋白) double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Foxa2 is required for induction and/or patterning of several distinct cell types in the ventral CNS.
Together SMAD3 (显示 SMAD3 蛋白) and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE).
HNF3beta target genes function to limit the extent of mesoderm formation in the Xenopus gastrula.
Data indicate a role for forkhead box A2 (FOXA2) in regulation of adult uterine function and fertility and mice Lacking FOXA2 in the adult uterus are infertile.
Forkhead box A2regulates biliary heterogeneity during cholestatic liver injury in mouse models.
Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas.
our study demonstrates that Foxa2 is required in both alpha and beta cells for maintaining appropriate glucagon (显示 GCG 蛋白) and insulin (显示 INS 蛋白) levels and for keeping glucose homeostasis.
Loss of Interdependent Binding by the FoxO1 (显示 FOXO1 蛋白) and FoxA1 (显示 FOXA1 蛋白)/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin (显示 INS 蛋白)-sensitive Genes.
FoxA1 (显示 FOXA1 蛋白), FoxA2, and LIPG (显示 LIPG 蛋白) control the uptake of extracellular lipids for breast cancer growth.
The authors show herein that Nurr1 (显示 NR4A2 蛋白) and Foxa2 interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.
Authors identified thousands of enhancers that are bound by the master regulators HNF4A (显示 HNF4A 蛋白) and FOXA2 in a differentiation-dependent manner, subject to chromatin remodeling, and associated with differentially expressed target genes.
this study demonstrates that SIRT1 (显示 SIRT1 蛋白) controls the acetylation level of FOXA2 in a nutrient-dependent manner and in times of nutrient shortage the interaction between SIRT1 (显示 SIRT1 蛋白) and FOXA2 is reduced.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
fork head transcription factor FoxA2
, forkhead box protein A2
, forkhead box A2
, hepatic nuclear factor-3-beta
, hepatocyte nuclear factor 3, beta
, hepatocyte nuclear factor 3-beta
, transcription factor 3B
, axial protein
, HNF3-beta homolog A
, Hepatocyte nuclear factor 3-beta homolog A
, fork head domain-related protein 3
, forkhead box protein A2-A
, hepatocyte nuclear factor 3 beta
, hepatocyte nuclear factor 3 beta (winged helix transcription factor)
, hepatocyte nuclear factor-3 beta
, hepatocyte nuclear factor-3beta
, transcription factor Foxa2