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Reduced transcriptional activity associated with FOXA2 mutations.
might be a progesterone-induced gene, which may participate in the 'metastatic' process of eutopic endometrium to ectopic loci in patients with endometriosis
FOXA2 may act as a tumor suppressor and inhibit the epithelial-mesenchymal transition of endometrial cancer cells.
Our findings suggest that autophagy, through participation of FOXA2, maintains the characteristics of OCSCs. Autophagy and FOXA2 are therefore potential targets for ovarian cancer stem cell directed therapies.
MAPK and FoxA2 mediate CS-induced squamous metaplasia. MAPK inhibitors upregulate FoxA2, resulting in a reduction in the degree of squamous metaplasia.
In conclusion, our data suggest that overexpression of the Hedgehog components SHH, GLI2 and FOXA2 might be used as markers of an aggressive hemangioma.
Our results suggest that FoxA2 plays a key role in the expression of hepatic phenotype of AFP-producing adenocarcinomas.
FOXA2 is a specific and sensitive molecular marker for small cell neuroendocrine carcinoma of the prostate.
HNF3beta plays a vital role in regulation of CPS1 gene and could promote the metabolism of ammonia by regulating CPS1 expression.
The c.505T>C, p.S169P genetic variant occurs at the conserved forkhead DNA binding domain of the FOXA2 and causes a rare and unique clinical phenotype of hypopituitarism, CHI, dysmorphic features, liver, pancreas, heart and gastrointestinal abnormalities.
Results showed that FOXA2 expression was decreased during Il-13 induced goblet cell differentiation but DNA methylation of its promoter was not changed. In the absence of Il-13, no difference was found for FOXA2 expression but hypomethylation of CpG # 10 and 11 in the its promoter was detected. These findings suggest that aberrant DNA methylation of FOXA2 is one of the factors underlying mucus hypersecretion in COPD.
the findings of the current study provide compelling genetic evidence that FOXA2 is a pathogenic driver gene in the etiology of primary uterine cancers, including uterine carcinosarcomas and carcinomas.
A molecular mechanism by which Estradiol antagonizes GR-dependent induction of specific genes by preventing the recruitment of the pioneer factors FOXA1 and FOXA2 in a physiologically relevant model.
Physical and functional interactions between LXRalpha and FOXA2 were established in vitro and ex vivo.
SIRT1 directly interacts with and deacetylates Foxa2 to inhibit its transcriptional activity on expression of genes involved in bile acids synthesis and transport.
Iotansulin decreased LPL mRNA levels in HepG2 cells and this was associated with phosphorylation of AKT and nuclear export of FOXA2.
findings provide the structural basis for FOXA2 protein binding to a consensus forkhead site and elucidate how members of the forkhead protein family bind different DNA sites.
Low FOXA2 expression is associated with metastasis of gastric cancer.
FOXA2 identified as a novel tumor suppressor in pancreatic cancer. It is regulated directly by miR-199a.
This study used combined immunohistochemical staining for a marker of hepatic commitment and specification (FOXA2 [Forkhead box A2]), hepatocyte maturation (Albumin and HepPar1), and features of bile ducts (CK19 [cytokeratin 19]) to identify lineages of stem cells differentiating toward the hepatocytic or bile ductular compartments of end-stage cirrhotic human liver.
in FoxA2-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Foxa2 is required for induction and/or patterning of several distinct cell types in the ventral CNS.
Together SMAD3 and ZIC2 regulate FOXA2 transcription in cultured cells and Zic2 also controls the foxA2 expression during Xenopus development. These findings reveal a new mechanism of NODAL signal transduction in the mammalian node and provide the first molecular explanation of how ZIC2 loss-of-function precipitates Holoprosencephaly (HPE).
HNF3beta target genes function to limit the extent of mesoderm formation in the Xenopus gastrula.
Study compared age and tissue- specific methylation differences in the brain and spleen of young and aged mice. There were 75 hypermethylated Foxa2 binding sites across a 2.7 Mb region of chromosome 11. Hypomethylated loci were clustered around Mid1, Isoc2b and genome-wide loci with binding sites for Foxa2 and Esr1, which are known to play important roles in development and aging.
Maturation of pancreatic beta-cells requires the cooperative function of Foxa2 and Pdx1.
Data indicate a role for forkhead box A2 (FOXA2) in regulation of adult uterine function and fertility and mice Lacking FOXA2 in the adult uterus are infertile.
Forkhead box A2regulates biliary heterogeneity during cholestatic liver injury in mouse models.
Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas.
our study demonstrates that Foxa2 is required in both alpha and beta cells for maintaining appropriate glucagon and insulin levels and for keeping glucose homeostasis.
Loss of Interdependent Binding by the FoxO1 and FoxA1/A2 Forkhead Transcription Factors Culminates in Perturbation of Active Chromatin Marks and Binding of Transcriptional Regulators at Insulin-sensitive Genes.
FoxA1, FoxA2, and LIPG control the uptake of extracellular lipids for breast cancer growth.
The authors show herein that Nurr1 and Foxa2 interact to protect midbrain dopaminergic neurons against various toxic insults, but their expression is lost during aging and degenerative processes.
Authors identified thousands of enhancers that are bound by the master regulators HNF4A and FOXA2 in a differentiation-dependent manner, subject to chromatin remodeling, and associated with differentially expressed target genes.
this study demonstrates that SIRT1 controls the acetylation level of FOXA2 in a nutrient-dependent manner and in times of nutrient shortage the interaction between SIRT1 and FOXA2 is reduced.
Hh signaling upregulated FOXA2, which induced expression of MUC2, an intestinal mucin found in Barrett's esophagus, and the MUC2-processing protein AGR2
through interactions with FoxA2, Arx positively regulates Shh expression in the floor plate, and Shh signaling in turn activates Nkx2.2, which suppresses Arx expression.
studies have identified a novel TXNIP/miR-124a/FoxA2/IAPP signaling cascade linking the critical beta-cell signaling pathways of TXNIP and IAPP
The interplay of Nurr1 and Foxa2 is the crucial determinant for dopamine phenotype acquisition during midbrain dopaminergic neuron development.
Nuclear HNF3beta signaling is regulated by estrogen receptors in non-tumor intestinal mucosa.
Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression.
Foxa2 is required for normal airway epithelial differentiation, and its deletion causes goblet-cell metaplasia and Th2-mediated pulmonary inflammation during postnatal development.
Findings suggest that Onecut1 suppresses MafA gene expression through the Foxa2-binding site.
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.
fork head transcription factor FoxA2
, forkhead box protein A2
, forkhead box A2
, hepatic nuclear factor-3-beta
, hepatocyte nuclear factor 3, beta
, hepatocyte nuclear factor 3-beta
, transcription factor 3B
, axial protein
, HNF3-beta homolog A
, Hepatocyte nuclear factor 3-beta homolog A
, fork head domain-related protein 3
, forkhead box protein A2-A
, hepatocyte nuclear factor 3 beta
, hepatocyte nuclear factor 3 beta (winged helix transcription factor)
, hepatocyte nuclear factor-3 beta
, hepatocyte nuclear factor-3beta
, transcription factor Foxa2