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DNA replication licensing factor Cdc6 is recruited to the proximal side of the centrioles via cyclin A to negatively regulate centrosome duplication by binding and inhibiting the cartwheel protein Sas-6 from forming a stable complex with another centriole duplication core protein, STIL.
Results show that both Cdc6 and Cdt1 (显示 CDT1 蛋白), when expressed in a high level, alone or in combination, were significantly associated with poorer survival in the breast cancer patient cohort. In line with this finding, the expression of Cdc6 and Cdt1 (显示 CDT1 蛋白) was upregulated in breast cancer cells compared to normal breast epithelial cells. Expression of Cdc6 and Cdt1 (显示 CDT1 蛋白) was significantly higher in ER negative breast cancer.
Results suggested that Cdc6 controls centrosome duplication in a manner independent of its recruitment of PCM (显示 PCMT1 蛋白) proteins to the centrosome.
WHSC1L1 (显示 WHSC1L1 蛋白) and H3K36me2 are enriched in the gene bodies of the cell cycle-related genes CDC6 and CDK2 (显示 CDK2 蛋白), implying that WHSC1L1 (显示 WHSC1L1 蛋白) directly regulates the transcription of these gene
Cdc6 expression is up-regulated in bladder cancer tissues and is positively correlated to high tumor grade.
PPP2R3B (显示 PPP2R3B 蛋白) codes for the PR70 protein, a regulatory substrate-recognizing subunit of protein phosphatase 2A. PR70 decreased melanoma growth by negatively interfering with DNA replication and cell cycle progression through its role in stabilizing CDC6-chromatin licensing and CDT1 (显示 CDT1 蛋白) interaction
AZD7762 demonstrates synergy with regard to inhibition of AR-CDC6-ATR (显示 ANTXR1 蛋白)-Chk1 (显示 CHEK1 蛋白) signaling.
The opposing effects of ORC1 (显示 ORC1L 蛋白) (represor) and CDC6 (gene activator) in controlling the level of Cyclin E (显示 CCNE1 蛋白) ensures genome stability and a mechanism for linking directly DNA replication and cell division commitment.
Data suggest that regulation of microtubule nucleation and recruitment of pericentriolar proteins to centrosome requires Cdc6 ATPase activity, as well as centrosomal localization of Cdc6.
6 overexpression may contribute to the high proliferation and low apoptosis in chronic myeloid leukemia (显示 BCL11A 蛋白) cells and can be regulated by BCR/ABL (显示 ABL1 蛋白) signal transduction through downstream phosphoinositide 3-kinase/Akt (显示 AKT1 蛋白) and Janus kinase/signal transducer and activator of transcription (显示 STAT1 蛋白) pathways, suggesting cell division cycle protein 6 as a potential therapeutic target in chronic myeloid leukemia (显示 BCL11A 蛋白).
Dele (显示 KIAA0141 蛋白) and Cdc6 G-quadruplex formation is significant in the transcriptional regulation. Dele (显示 KIAA0141 蛋白) and Cdc6 G-quadruplex DNA alone possess enhancer and promotor function.
CDK1 (显示 CDK1 蛋白) activation proceeds with concomitant inhibition by CDC6, which tunes the timing of the M-phase entry during the embryonic cell cycle
Cdc6 continued to block apoptosome assembly induced by a non-cytochrome c (显示 CYCS 蛋白) or some other mechanism, suppressing seemingly unintended apoptosis when promoting cell proliferation
show that MyoD can occupy an E-box within the promoter of Cdc6 and that this association, along with E2F3a, is required for its activity.
CDC6 is essential for spindle formation in mouse oocytes
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins.
CDC6 cell division cycle 6 homolog
, CDC6-related protein
, cdc18-related protein
, cell division control protein 6 homolog
, cell division cycle 6 homolog