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Hamster Monoclonal XRCC6 Primary Antibody for ICC, FACS - ABIN151413
Doster, Ziegler, Foermer, Rieker, Heeg, Bekeredjian-Ding: Phosphorothioate-modified CpG oligodeoxynucleotides mimic autoantigens and reveal a potential role for Toll-like receptor 9 in receptor revision. in Immunology 2013
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Human Polyclonal XRCC6 Primary Antibody for WB - ABIN151802
Nash, Chen, Salganik, Muzyczka: Identification of cellular proteins that interact with the adeno-associated virus rep protein. in Journal of virology 2008
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Human Monoclonal XRCC6 Primary Antibody for IF, IHC (p) - ABIN560973
Nishii, Nakano, Nakamura, Wate, Shinde, Kaneko, Kusaka: Myonuclear breakdown in sporadic inclusion body myositis is accompanied by DNA double strand breaks. in Neuromuscular disorders : NMD 2011
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Human Monoclonal XRCC6 Primary Antibody for IHC (fp), IF - ABIN966469
Ajmani, Satoh, Reap, Cohen, Reeves: Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis. in The Journal of experimental medicine 1995
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Human Monoclonal XRCC6 Primary Antibody for IF, IHC (p) - ABIN2475248
Slupianek, Poplawski, Jozwiakowski, Cramer, Pytel, Stoczynska, Nowicki, Blasiak, Skorski: BCR/ABL stimulates WRN to promote survival and genomic instability. in Cancer research 2011
The DNA binding domain of Ku70 was essential for formation of the Ku70-STING complex. Knocking down STING in primary human macrophages inhibited their ability to produce IFN-lambda1 in response to transfection with DNA or infection with the DNA virus HSV-2 (herpes simplex virus-2). Together, these data suggest that STING mediates the Ku70-mediated IFN-lambda1 innate immune response to exogenous DNA or DNA virus infection.
analysis of a novel cellular stress response mechanism in cancer cells and a key role of LSD1/SIRT1/KU70 dynamic interaction in regulating DNA repair and mutation acquisition
Single nucleotide polymorphisms in the Ku70 gene XRCC6 were independently associated with Elevated Creatine Kinase Levels in Unhealthy Male Nonagenarians.
HTLV-1 infection enhanced the association between Ku70 and stimulator of IFN genes, suggesting that stimulator of IFN genes was involved in Ku70-mediated host defenses against HTLV-1 infection; findings suggest a new sensor that detects HTLV-1 reverse transcription intermediate and controls HTLV-1 replication
Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation.
Results show that DDB2 (显示 DDB2 抗体) is critical for chromatin association of XRCC5 (显示 XRCC5 抗体)/6 in the absence of DNA damage and provide evidence that XRCC5 (显示 XRCC5 抗体)/6 are functional partners of DDB2 (显示 DDB2 抗体) in its transcriptional stimulatory activity.
High KU70 expression is associated with drug resistance in glioblastoma.
These results suggest that Ku-mediated repression of p53 (显示 TP53 抗体) mRNA translation constitutes a novel mechanism linking DNA repair and mRNA translation.
VCP removes sterically trapped Ku70/80 rings from DNA in double-strand break repair.
found that the rs228593, rs2267437 and rs1805388 functional polymorphisms probably alter the level of expression of the ATM (显示 ATM 抗体), XRCC6 and LIG4 (显示 LIG4 抗体) genes, respectively, being important in the maintenance of genomic instability in MDS (显示 PAFAH1B1 抗体)
Ku70 is epistatic with XLF and DNA-PKcs and support a model in which inactivation of Ku70 allows DNA lesions to become accessible to alternative DNA repair pathways (other than Classical Non-Homologous End-Joining (C-NHEJ)).
Study found that emphysema occurred in ku70(-/-) mice at the age of three-months old, and that Bax deficiency was able to suppress it. These results suggest that Bax-mediated apoptosis induces emphysema in ku70(-/-) mice.
Bax deficiency appeared to delay the development of emphysema. This study suggests that enhanced Bax activity exacerbates the negative impact of Ku70 deletion
Ku (ku70/ku80 (显示 XRCC5 抗体) heterodimer)roles in nonhomologous end joining and base excision repair pathways of DNA repair are overviewed.
A novel role for free Ku70 and free Ku80 (显示 XRCC5 抗体) in altering base excision repair.
A novel function of Ku70 essential for colon homeostasis.
Overexpression of Bcl2 rescues the hematopoietic stem cell defect in Ku70-deficient mice by restoration of quiescence.
This study highlights Ku70 as an important player not only in maintaining genomic stability through NHEJ-dependent functions, but also in regulating pancreatic beta-cell proliferation, a novel NHEJ-independent function.
Ku70/80 binds to DNA double strand breaks (DSB) in all cell cycle stages and is likely actively displaced from DSB ends to free the DNA ends for DNA end resection and thus homologous recombination to occur.
The findings suggest that Artemis (显示 DCLRE1C 抗体) can work in not only the Ku-dependent repair process, but also the Ku-independent process at DNA double-strand break in living epithelial cells.
The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.
ATP-dependent DNA helicase 2 subunit 1
, ATP-dependent DNA helicase II, 70 kDa subunit
, X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)
, X-ray repair cross-complementing protein 6
, 5'-dRP lyase Ku70
, 5'-deoxyribose-5-phosphate lyase Ku70
, 70 kDa subunit of Ku antigen
, ATP-dependent DNA helicase II 70 kDa subunit
, CTC box binding factor 75 kDa subunit
, CTC box-binding factor 75 kDa subunit
, DNA repair protein XRCC6
, Ku autoantigen p70 subunit
, Ku autoantigen, 70kDa
, lupus Ku autoantigen protein p70
, thyroid autoantigen 70kD (Ku antigen)
, thyroid autoantigen 70kDa (Ku antigen)
, thyroid-lupus autoantigen p70
, 5'-dRP/AP lyase Ku70
, Ku p70
, ku autoantigen protein p70 homolog
, thyroid autoantigen 70 kDa
, Ku70 DNA-binding component of DNA-dependent proteinkinase complex (thyroid autoantigen 70 kDa)
, thyroid autoantigen
, X-ray repair cross-complementing protein 5