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Human Polyclonal XRCC2 Primary Antibody for WB - ABIN1882001
Schwarz, Daley, Beckhaus, Dötsch, Bernhard: Cell-free expression profiling of E. coli inner membrane proteins. in Proteomics 2010
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Human Monoclonal XRCC2 Primary Antibody for IF, ELISA - ABIN521426
Shammas, Shmookler Reis, Koley, Batchu, Li, Munshi: Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. in Blood 2009
Mouse (Murine) Polyclonal XRCC2 Primary Antibody for IHC, WB - ABIN3022570
Dong, Wang, Wang, Zhang, Zhu, Gao, Yang, Qin, Liang, Chen, Deng, Ning, Liang, Gao, Xu: A stress-induced cellular aging model with postnatal neural stem cells. in Cell death & disease 2014
Truncating variants in PALB2, ATM and CHEK2 , but not XRCC2 were associated with increased breast cancer risk.
meta-analysis indicates that XRCC2 rs3218536 and ERCC2 (显示 ERCC2 抗体) rs13181 polymorphisms may not be associated with the risk of ovarian cancer
Study has shown that most rare XRCC2 missense variants have little effect on XRCC2 protein function and are unlikely to be associated with familial and early-onset breast cancer.
involvement of ZNF281 (显示 ZNF281 抗体) in the cellular response to genotoxic stress through the control exercised on the expression of genes that act in different repair mechanisms
XRCC2 is shown to be the 20th Falconi anemia (FA) gene and is 2nd RAD51 (显示 RAD51 抗体) paralog so identified. XRCC2 is required to maintain levels of other RAD51 (显示 RAD51 抗体) paralogs that are normally present in XRCC2-RAD51B (显示 Rad51B 抗体)-C-D complex.
Polymorphism of XRCC2 gene is associated with Nasopharyngeal Carcinoma.
Results indicate that eight polymorphisms of XRCC1 (显示 XRCC1 抗体), XRCC2, and XRCC3 (显示 XRCC3 抗体) gene might be related to individual susceptibility to differentiated thyroid cancer (DTC) in Chinese population suggesting that XRCC1 (显示 XRCC1 抗体) (rs25487, rs25489, rs1799782), XRCC2 (rs3218536), and XRCC3 (显示 XRCC3 抗体) (rs1799794, rs56377012, rs1799796, rs861539) are novel genetic risk markers for DTC.
Results indicate that homologous recombination repair genes XRCC2 Arg188His and XRCC3 (显示 XRCC3 抗体) Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.
Suggest that XRCC2 is a useful predictive biomarker of preoperative radiotherapy treatment response in locally advanced rectal cancer patients.
The XRCC2 Arg188His polymorphism was associated with the risk of ovarian cancer. (Meta-analysis)
Data show that XRCC2 and other homologous recombination proteins, including the key recombinase (显示 RAG1 抗体) RAD51 (显示 RAD51 抗体), co-localize with the centrosome, potentially to coordinate the deployment of a DNA damage response at vulnerable phases of the cell cycle.
These findings indicate that Xrcc2 haploinsufficiency reduces spontaneous tumor incidence on an Apc (显示 APC 抗体)(min/+) background but increases the tumorigenic response to radiation.
An important function of XRCC2 is to enhance the activity of RAD51 (显示 RAD51 抗体), so that the loss of XRCC2 results in a severe delay in the early response of RAD51 (显示 RAD51 抗体) to DNA damage.
Order-of-magnitude higher levels of chromosomal alterations are sustained in primary or immortal Xrcc2(-/-) embryonic fibroblasts.
the normal developmental programme is perturbed in Xrcc2-/- embryonic tissues, particularly during neurogenesis and somitogenesis
ATP hydrolysis by Rad51 (显示 RAD51 抗体) is more important for some homologous recombination functions than it is for other aspects of DNA repair
Xrcc2 is important to preserve or restore replication forks during rapid clonal expansion of developing lymphocytes.
DNA replication licensing factor MCM2 (显示 MCM2 抗体) and DNA mismatch repair (MMR (显示 MRC1 抗体)) protein MSH2 (显示 MSH2 抗体) were confirmed to be present in co-precipitations with MmXRCC2.
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.
X-ray repair cross complementing protein 2
, X-ray repair complementing defective repair in Chinese hamster cells 2
, DNA repair protein XRCC2
, X-ray repair cross-complementing protein 2
, recA/RAD51 family protein