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UIMC1 抗体

(Ubiquitin Interaction Motif Containing 1 (UIMC1))
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).
UIMC1 抗体  (AA 161-235) UIMC1 抗体  (AA 161-235) UIMC1 抗体 (AA 161-235) (ABIN7145750)

UIMC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

UIMC1 抗体  (AA 1-385) UIMC1 抗体  (AA 1-385) UIMC1 抗体 (AA 1-385) (ABIN526885)

UIMC1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

UIMC1 抗体  (AA 1-230) UIMC1 抗体  (AA 1-230) UIMC1 抗体 (AA 1-230) (ABIN6149915)

UIMC1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

UIMC1 抗体 by Grade

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UIMC1 抗体 by 适用

Find UIMC1 抗体 for a variety of species such as anti-Human UIMC1, anti-Mouse UIMC1, anti-Rat UIMC1. The species listed below are among those available. Click on a link to go to the corresponding products.

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UIMC1 抗体 by 抗原表位

Find UIMC1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

UIMC1 抗体 by 克隆形成能力

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UIMC1 抗体 by 克隆

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UIMC1 抗体 by 标记

Find UIMC1 抗体 with a specific conjugate such as FITC, Alexa Fluor 488, Alexa Fluor 555. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular UIMC1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7145750
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN526885
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN6149915
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, FACS
Validations
  • (1)
  • (2)
Cat. No. ABIN1944736
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN526883
Quantity 50 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF
Validations
  • (1)
Cat. No. ABIN7263231
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN570767
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7271136
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN500569
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC (p), EIA
Validations
  • (2)
Cat. No. ABIN500567
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application
Validations
Cat. No. ABIN7145752
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7145753
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN7145751
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
Cat. No. ABIN6389424
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, ELISA, IF, IHC (p)
Validations
Cat. No. ABIN6990792
Quantity 0.1 mg
Datasheet Datasheet

Latest Publications for our UIMC1 抗体

Baranes-Bachar, Levy-Barda, Oehler, Reid, Soria-Bretones, Voss, Chung, Park, Liu, Yoon, Li, Dellaire, Misteli, Huertas, Rothenberg, Ramadan, Ziv, Shiloh: "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair." in: Molecular cell, Vol. 69, Issue 5, pp. 866-878.e7, (2019) (PubMed).

Bodo, Campagne, Thin, Higginson, Vargas, Hua, Fuller, Ackerstaff, Russell, Zhang, Klingler, Cho, Kaag, Mazaheri, Rimner, Manova-Todorova, Epel, Zatcky, Cleary, Rao, Yamada, Zelefsky, Halpern et al.: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).

Watanabe, Iimori, Chan, Hara, Kitao, Maehara: "MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites." in: Scientific reports, Vol. 8, Issue 1, pp. 10888, (2018) (PubMed).

Yasuhara, Kato, Hagiwara, Shiotani, Yamauchi, Nakada, Shibata, Miyagawa: "Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair." in: Cell, Vol. 175, Issue 2, pp. 558-570.e11, (2018) (PubMed).

Ha, Ma, Lin, Tang, Lian, Zhao, Li, Zhen, Pei, Han, Malumbres, Jin, Chen, Zhao, Zhu, Zhang: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." in: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).

Renaud, Barascu, Rosselli: "Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells." in: Nucleic acids research, Vol. 44, Issue 2, pp. 648-56, (2016) (PubMed).

Lin, Ratner, Whicker, Lee, Sartorelli: "Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors." in: Molecular cancer research : MCR, Vol. 12, Issue 3, pp. 381-93, (2014) (PubMed).

Kato, Nakajima, Ui, Muto-Terao, Ogiwara, Nakada: "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice." in: Molecular cell, Vol. 53, Issue 4, pp. 617-30, (2014) (PubMed).

Hu, Paul, Wang: "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25510-9, (2012) (PubMed).

Hu, Kim, Castillo, Huang, Liu, Wang: "NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11734-45, (2011) (PubMed).

Aliases for UIMC1 抗体

ubiquitin interaction motif containing 1 (UIMC1) 抗体
ubiquitin interaction motif containing 1 (Uimc1) 抗体
9430016E08Rik 抗体
D330018D10Rik 抗体
D630032M02Rik 抗体
RAP80 抗体
RGD1307009 抗体
RIP110 抗体
Rxrip110 抗体
UIMC1 抗体
X2HRIP110 抗体
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