|抗原||PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This PMS2 antibody is un-conjugated 其他选择|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
|Supplier||Log in to see|
PMS2抗体详情PMS2目标详情 使用细节 贮存及处理 图像
|特异性||The antibody recognizes ~100 kDa PMS2.|
|纯化方法||Peptide Affinity Chromatography.|
|免疫原||Synthetic peptide surrounding amino acid 846 of human PMS2|
|Plasmids, Primers & others|
PMS2目标详情PMS2抗体详情 使用细节 贮存及处理 图像 回页首
|别名||PMS2 (PMS2 Antibody 摘要)|
|背景||Inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were initially demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 - 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.Synonyms: DNA mismatch repair protein PMS2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMSL2|
|途径||DNA Damage Repair, Production of Molecular Mediator of Immune Response|
使用细节PMS2抗体详情 PMS2目标详情 贮存及处理 图像 回页首
Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 10-20 μg/mL. Immunohistochemistry: 10-20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理PMS2抗体详情 PMS2目标详情 使用细节 图像 回页首
|缓冲液||PBS containing 30 % Glycerol, 0.5 % BSA, and 0.01 % Thimerosal.|
|注意事项||This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||-20 °C/-80 °C|
|储存方法||Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.|