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Human MCM2 Protein expressed in Wheat germ - ABIN1310547
Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia. in Journal of immunological methods 2011
Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
the foxn1 (显示 FOXN1 蛋白)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
The findings suggest that Mcm-2 may be a sensitive proliferation marker in oral potentially malignant and malignant lesions which may be useful for differentiating between Verrucous Hyperplasia (VH) with/ without dysplasia, Verrucous Carcinoma (VC) and Oral Squamous Cell Carcinoma (OSCC).
High MCM2 expression is associated with HIV-1 infection.
The results showed that MUS81 (显示 MUS81 蛋白) modulates MCM2 levels as well as homologous recombination (HR) activity. Moreover, downregulation of MUS81 (显示 MUS81 蛋白) increased the sensitivity of epithelial ovarian cancer (EOC)cells to olaparib by inducing S phase arrest and promoting apoptosis through activation of MCM2. MUS81 (显示 MUS81 蛋白) may be a potential novel therapeutic target for EOC.
MCM2 played important roles in regulating cell cycle- and DNA replication-related pathways. E2F (显示 E2F1 蛋白) could upregulate the expression levels of MCM2 by deregulating the methylations of their promoters to promote the relapse of Acute Lymphoblastic Leukemia .
ProEx C is an immunohistochemical cocktail containing antibodies direct against topoisomerase IIalpha (TOP2A (显示 TOP2A 蛋白)) and minichromosome maintenance 2 (MCM2) proteins. This brief review covers the effective utility of ProEx C as adjunct tool in assessing the urothelial lesions in urine cytology, also providing prognostic and therapeutic information to help in clinical decisions.
the decreased growth of osteosarcoma cells by MCM2 or MCM3 knockdown was reversed by DHX9 overexpression, indicating that MCM2 and MCM3 activity was DHX9-dependent.
Results show that MCM2 is significantly upregulated in urothelial carcinoma.
Sld5 a component of GINS complex interacts with SIK1 and recruits it to the sites of DNA replication at the onset of S phase.
MCM2 expression in serrated colonic polyps demonstrates aberrant cellular proliferation and changes in the colonic microenvironment may promote adenoma morphogenesis and predisposition to malignancy.
these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) through physically binding miR (显示 MLXIP 蛋白)-374a and MCM2. It may also be one of the reasons for HCC (显示 FAM126A 蛋白) gender disparity and may potentially contribute to HCC (显示 FAM126A 蛋白) treatment
Data show that MRE11- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG) helicase complex.
Mcm2-7 associate with Cdc45 (显示 CDC45 蛋白) and GINS to form a relatively stable CMG (显示 CASK 蛋白) (Cdc45 (显示 CDC45 蛋白)-MCM-GINS) complex.
ATM (显示 ATM 蛋白) and ATR phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts
MCM2-7 is the replicative helicase, dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication
Segregation of parental histones to the leading strand increased markedly in cells with histone-binding mutations in MCM2, part of the replicative helicase, exacerbating histone posttranslational modifications sister chromatid asymmetry.
MCM2 is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus. expression of Mcm2 is induced by progesterone action in the mouse uterine stroma. siRNA-mediated silencing of MCM2 arrests the cell cycle at G1-S transition during stromal cell proliferation. downregulation of Mcm2 could also compromise stromal cell differentiation.
MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.
these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.
Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (显示 EMB 蛋白).
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.
gp70 (显示 EMB 蛋白) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (显示 ACIN1 蛋白) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (显示 TP53 蛋白).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
, minichromosome maintenance 2
, DNA replication licensing factor mcm2
, MCM2 minichromosome maintenance deficient 2, mitotin
, minichromosome maintenance protein 2
, DNA replication licensing factor MCM2
, cell devision cycle-like 1
, cyclin-like 1
, minichromosome maintenance deficient 2 (mitotin)
, minichromosome maintenance protein 2 homolog
, nuclear protein BM28
, minichromosome maintenance deficient 2 mitotin
, minichromosome maintenance complex component 7
, mini chromosome maintenance deficient 2