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LIG4 抗体

(Ligase IV, DNA, ATP-Dependent (LIG4))
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
LIG4 抗体  (C-Term) LIG4 抗体  (C-Term) LIG4 抗体 (C-Term) (ABIN6262967)

LIG4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

LIG4 抗体  (AA 612-911) LIG4 抗体  (AA 612-911) LIG4 抗体 (AA 612-911) (ABIN3022475)

LIG4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

LIG4 抗体  (N-Term) LIG4 抗体  (N-Term) LIG4 抗体 (N-Term) (ABIN2778272)

LIG4 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

LIG4 抗体 by Grade

Find LIG4 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

LIG4 抗体 by 适用

Find LIG4 抗体 for a variety of species such as anti-Human LIG4, anti-Mouse LIG4, anti-Rat LIG4. The species listed below are among those available. Click on a link to go to the corresponding products.

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Find LIG4 抗体 validated for a specific application such as WB, ELISA, IF (cc), IF (p). Some of the available applications are listed below. Click on a link to go to the corresponding products.

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LIG4 抗体 by 抗原表位

Find LIG4 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

LIG4 抗体 by 克隆形成能力

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LIG4 抗体 by 克隆

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LIG4 抗体 by 标记

Find LIG4 抗体 with a specific conjugate such as Alexa Fluor 488, Alexa Fluor 555, Alexa Fluor 594. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular LIG4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (4)
Cat. No. ABIN6262967
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (2)
  • (3)
Cat. No. ABIN3022475
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN2778272
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN517510
Quantity 100 μg
Datasheet Datasheet
Reactivity Horse, Human, Monkey
Application WB, IHC, IHC (p)
Validations
  • (2)
Cat. No. ABIN202951
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (2)
  • (1)
Cat. No. ABIN2857063
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Human
Application WB, IHC, IF, IC
Validations
  • (3)
Cat. No. ABIN7296182
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application IHC, ELISA
Validations
  • (1)
Cat. No. ABIN7246691
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN948087
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN7268253
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IF
Validations
Cat. No. ABIN6989825
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Validations
Cat. No. ABIN1386075
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IHC (fro)
Validations
Cat. No. ABIN1396062
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN1396058
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF (cc), IF (p)
Validations
Cat. No. ABIN1396059
Quantity 100 μL
Datasheet Datasheet

Latest Publications for our LIG4 抗体

Hu, Shiflett, Kobayashi, Chao, Wilson, Mohr, Huang: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." in: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).

Zhang, Chang, Sun, Chen, Yang, Tang, Jing, Kang, He, Wu, Wei, Wang, Xu, Zhu, Shen, Zeng, Wang, Liu, Zhang, Mao, Jiang, Sun: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).

Li, Zhang, Chen, Guo, Zhang, Tang, Xu, Zhang, Tao, Wang, Jiang, Sun, Mao: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).

Ly, Teitz, Kim, Shoshani, Skaletsky, Fachinetti, Page, Cleveland: "Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining." in: Nature cell biology, Vol. 19, Issue 1, pp. 68-75, (2017) (PubMed).

Zhu, Fisher, Bessho, Peng: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." in: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).

Sousa, Zub, Aas, Hanssen-Bauer, Demirovic, Sarno, Tian, Liabakk, Slupphaug: "An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells." in: PLoS ONE, Vol. 8, Issue 2, pp. e55493, (2013) (PubMed).

Ching, Dobner, Koyuncu: "The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2." in: Journal of virology, Vol. 86, Issue 5, pp. 2400-15, (2012) (PubMed).

Ducu, Dayaram, Marriott: "The HTLV-1 Tax oncoprotein represses Ku80 gene expression." in: Virology, Vol. 416, Issue 1-2, pp. 1-8, (2011) (PubMed).

Aliases for LIG4 抗体

ligase IV, DNA, ATP-dependent (lig4) 抗体
DNA ligase 4 (LIG4) 抗体
DNA ligase 4 (LOC100212302) 抗体
DNA ligase 4 (CpipJ_CPIJ005161) 抗体
DNA ligase 4 (PTRG_09982) 抗体
DNA ligase 4 (MCYG_05151) 抗体
DNA ligase 4 (LOC657210) 抗体
ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4) 抗体
DNA ligase IV (ATLIG4) 抗体
ligase IV, DNA, ATP-dependent L homeolog (lig4.L) 抗体
ligase IV, DNA, ATP-dependent (Lig4) 抗体
DNA ligase 4 (Lig4) 抗体
5830471N16Rik 抗体
DNA LIGASE IV 抗体
DNL4 抗体
lig4 抗体
LIG4 抗体
lig4-A 抗体
tiny 抗体
zgc:165595 抗体
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