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DDB1 抗体

(Damage Specific DNA Binding Protein 1 (DDB1))
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012].
DDB1 抗体  (C-Term) DDB1 抗体  (C-Term) DDB1 抗体 (C-Term) (ABIN184570)

Verified DDB1 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

DDB1 抗体  (C-Term) DDB1 抗体  (C-Term) DDB1 抗体 (C-Term) (ABIN2854664)

KO Validated DDB1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

DDB1 抗体 DDB1 抗体 DDB1 抗体 (ABIN7260707)

DDB1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

DDB1 抗体 by Grade

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DDB1 抗体 by 适用

Find DDB1 抗体 for a variety of species such as anti-Human DDB1, anti-Mouse DDB1, anti-Rat DDB1. The species listed below are among those available. Click on a link to go to the corresponding products.

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DDB1 抗体 by 克隆形成能力

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DDB1 抗体 by 标记

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Popular DDB1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA
Validations
  • (1)
  • (6)
Cat. No. ABIN184570
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (1)
  • (8)
Cat. No. ABIN2854664
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (5)
Cat. No. ABIN7260707
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP
Validations
  • (5)
Cat. No. ABIN1679509
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IP
Validations
  • (5)
Cat. No. ABIN7266673
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p)
Validations
  • (8)
Cat. No. ABIN3043823
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), ICC, IHC (fro)
Validations
  • (7)
Cat. No. ABIN4950780
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p)
Validations
  • (4)
Cat. No. ABIN514914
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IF, ICC
Validations
  • (3)
Cat. No. ABIN6266199
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IP, IHC (p)
Validations
  • (3)
Cat. No. ABIN396934
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA, IF
Validations
  • (2)
Cat. No. ABIN7150124
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN560580
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (2)
Cat. No. ABIN947784
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC (p), IHC (fro), IF (cc), IF (p)
Validations
  • (1)
Cat. No. ABIN742455
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7237955
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our DDB1 抗体

Moser, Basílio, Gotzmann, Brachner, Foisner: "Comparative Interactome Analysis of Emerin, MAN1 and LEM2 Reveals a Unique Role for LEM2 in Nucleotide Excision Repair." in: Cells, Vol. 9, Issue 2, (2020) (PubMed).

Wang, Sun, Zhu, Sun, Ma, Wang, Lu, Chen, Xu: "Quantitative proteomic analysis revealed changes in protein synthesis and mitochondrial functions after acute DNA damage in mouse neural stem cells." in: Neuroscience letters, Vol. 653, pp. 355-361, (2018) (PubMed).

Malatesta, Peschiaroli, Memmi, Zhang, Antonov, Green, Barlev, Garabadgiu, Zhou, Melino, Bernassola: "The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity." in: Oncogene, Vol. 32, Issue 39, pp. 4721-6, (2013) (PubMed).

Li, Robert, van Breugel, Strubin, Zheng: "A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery." in: Nature structural & molecular biology, Vol. 17, Issue 1, pp. 105-11, (2010) (PubMed).

Leung-Pineda, Huh, Piwnica-Worms: "DDB1 targets Chk1 to the Cul4 E3 ligase complex in normal cycling cells and in cells experiencing replication stress." in: Cancer research, Vol. 69, Issue 6, pp. 2630-7, (2009) (PubMed).

Westbrook, Martin, Schlabach, Leng, Liang, Feng, Zhao, Roberts, Mandel, Hannon, Depinho, Chin, Elledge: "A genetic screen for candidate tumor suppressors identifies REST." in: Cell, Vol. 121, Issue 6, pp. 837-48, (2005) (PubMed).

Rapić-Otrin, McLenigan, Bisi, Gonzalez, Levine: "Sequential binding of UV DNA damage binding factor and degradation of the p48 subunit as early events after UV irradiation." in: Nucleic acids research, Vol. 30, Issue 11, pp. 2588-98, (2002) (PubMed).

Sun, Lu, Chao: "Identification of rat DDB1, a putative DNA repair protein, and functional correlation with its damaged-DNA recognition activity." in: Journal of biomedical science, Vol. 9, Issue 4, pp. 371-80, (2002) (PubMed).

Shiyanov, Nag, Raychaudhuri: "Cullin 4A associates with the UV-damaged DNA-binding protein DDB." in: The Journal of biological chemistry, Vol. 274, Issue 50, pp. 35309-12, (2000) (PubMed).

Fujiwara, Masutani, Mizukoshi, Kondo, Hanaoka, Iwai: "Characterization of DNA recognition by the human UV-damaged DNA-binding protein." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 20027-33, (1999) (PubMed).

Aliases for DDB1 抗体

damage specific DNA binding protein 1 (DDB1) 抗体
damage-specific DNA binding protein 1, 127kDa (ddb1) 抗体
DNA damage-binding protein 1 (LOC100187356) 抗体
damage specific DNA binding protein 1 (Ddb1) 抗体
damage-specific DNA binding protein 1 (Ddb1) 抗体
DNA damage-binding protein 1 (ddb-1) 抗体
127kDa 抗体
AA408517 抗体
DDB1 抗体
ddb1 抗体
DDBA 抗体
ddba 抗体
p127-Ddb1 抗体
UV-DDB1 抗体
uv-ddb1 抗体
XAP1 抗体
xap1 抗体
XPCE 抗体
xpce 抗体
XPE 抗体
xpe 抗体
XPE-BF 抗体
xpe-bf 抗体
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