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Pronounced correlations between KLK10 (显示 KLK10 ELISA试剂盒)/KLK11 (显示 KLK11 ELISA试剂盒) (rs = 0.647) and between KLK9/KLK15 (显示 KLK15 ELISA试剂盒) (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases
Data suggest that mature KLK9 (kallikrein 9) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 appears to extend to KLK10 (显示 KLK10 ELISA试剂盒) and midkine (显示 MDK ELISA试剂盒); enzyme activity is enhanced by Mg2 (显示 MUC7 ELISA试剂盒)+ and Ca2 (显示 CA2 ELISA试剂盒)+, but is reversibly attenuated by Zn2+; KLK9 is inhibited in vitro by many naturally occurring or synthetic protease inhibitors.
Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival.
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.
, epidermal growth factor binding protein type C
, epidermal growth factor-binding protein type C
, glandular kallikrein K9
, kallikrein 9
, tissue kallikrein-9
, kallikrein-like protein 3
, kallikrein-related peptidase 9