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Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module + low-density lipoprotein receptor class A module + membrane attack complex/ (显示 LDLR 蛋白)perforin domain of C8 beta.
This is a study of the human C8 orthologs. Binding of C8 gamma subunit to C8 beta is dependent on the thrombospondin type 1 module, low-density lipoprotein receptor (显示 LDLR 蛋白) class A module, and membrane attack complex/perforin (显示 PRF1 蛋白) domain of C8 beta.
The protein encoded by this gene belongs to the lipocalin family. It is one of the three subunits that constitutes complement component 8 (C8), which is composed of a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 participates in the formation of the membrane attack complex (MAC) on bacterial cell membranes. While subunits alpha and beta play a role in complement-mediated bacterial killing, the gamma subunit is not required for the bactericidal activity.
complement component C8 gamma chain
, complement component 8, gamma subunit
, novel lipocalin protein
, complement component C8 gamma subunit