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C4BP is deposited in the diseased aortic valve, coincident with C3d (显示 C3 蛋白) expression.
whereas the presence of plasminogen (显示 PLG 蛋白) did not affect the factor I cofactor activity of C4BP, the activation of plasminogen (显示 PLG 蛋白) by urokinase-type plasminogen activator (显示 PLAU 蛋白) to active plasmin (显示 PLG 蛋白) was significantly augmented in the presence of C4BP.
C4BPB/C4BPA may not confer susceptibility to schizophrenia among Han Chinese
these data suggest that when C4BP is bound to Ail, fI can cleave and inactivate C4b (显示 C4B 蛋白) that has bound covalently to bacterial surface structures as well as C4b (显示 C4B 蛋白) bound noncovalently to Ail.
C4BP alpha7beta0 isoform complement control protein-6 domain of C4BP alpha-chain (显示 FCGRT 蛋白) is necessary for tolerogenic activity of the acute-phase C4BPbeta chain.
The Lsa30 (LIC110870) is a novel adhesin that binds plasminogen (显示 PLG 蛋白) and the complement regulator C4bp.
Human pneumococcal glycolytic enzyme enolase, a nonclassical cell surface and plasminogen-binding protein (显示 ENO1 蛋白), is a pneumococcal C4BP-binding protein.
NC4 Domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H (显示 CFH 蛋白).
C4BP is recruited to the S. aureus surface where it functions to inhibit C4 complement effectors, suggesting a previously undescribed immune evasion strategy for this pathogen.
Human pentraxin 3 binds to the complement regulator c4b-binding protein.
This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. Along with a single, unique beta-chain, seven identical alpha-chains encoded by this gene assemble into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Two pseudogenes of this gene are also found in the cluster.
C4b-binding protein alpha chain
, complement regulatory soluble protein
, proline-rich protein
, complement component 4 binding protein, alpha chain