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Anti-HLA class I (显示 MICA 蛋白) and class II C3d-binding donor-specific antibodies carried a twofold and 1.5-fold increased risk of kidney graft loss, respectively.
Here we have shown for the first time, that ligand- or insulin (显示 INS 蛋白)-mediated activation of PPARgamma (显示 PPARG 蛋白) in human hepatoma cell line HepG2 causes the downregulation of C3 gene expression and protein secretion
Single Nucleotide Polymorphism rs11569514 in C3 and haplotypes of C3 variants were associated with schizophrenia in a Han Chinese population.
C3F (显示 LPCAT3 蛋白) polymorphism is associated with viral infections and protection from rejection after liver transplantation.
Pra1 (显示 RABAC1 蛋白) targets C3 by cleaving C3 at a unique site. This inhibited effector function of the activation fragments. The newly formed C3a-like peptide lacked the C-terminal arginine residue needed for C3a-receptor binding and activation. Pra1 (显示 RABAC1 蛋白) also bound to C3a and C3b generated by human convertases and blocked their effector functions, C3a binding to human C3a receptor, C3 antifungal activity, and C3b deposition.
data provide the first evidence that T17M rhodopsin (显示 RHO 蛋白) mutant disrupts C3 secretion via the induction of ROS (显示 ROS1 蛋白) and the suppression of TWIST1 (显示 TWIST1 蛋白).
The complement activation factors Bb, C3a, C5a, and MAC were increased significantly in early-onset severe pre-eclampsia (EOSPE) (all P<.01) and late-onset severe pre-eclampsia (LOSPE). (P value: .027, <.001, .001, and <.001, respectively) compared with E/L-control. C1q and C4d were increased significantly in LOSPE (P value: .003 and .014, respectively) compared with L-control.
This study enclosed strong synergistic association of risk genotypes of C3 and CFH (显示 CFH 蛋白) Y402H with AMD (显示 AMD1 蛋白). We also revealed synergistic influence of CCL2 (显示 CCL2 蛋白)-2518 and the at-risk genotype of the C3 in AMD (显示 AMD1 蛋白) with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2 (显示 CCL2 蛋白)-2518 polymorphism is not an innocent bystander (显示 SEPT1 蛋白) in AMD (显示 AMD1 蛋白) susceptibility when combined with the at-risk genotype of C3 (R102G).
Our study shows C3 to be a relatively strong susceptibility gene for advanced-type-AMD (显示 AMD1 蛋白) (exudative-and-geographic-atrophy) in an Iranian population.
BBB disruption is present in ACS (显示 PLA2G15 蛋白), and elevated levels of IL-6 (显示 IL6 蛋白) and C3 in CSF (显示 CSF2 蛋白) in diffuse NPSLE
Data report C3 as a novel myogenic factor (显示 MYOG 蛋白) secreted by undifferentiated preadipocyte that enhances myogenic differentiation of fetal progenitor cells and adult cells. The results show that complement C3 molecule internalizes myogenic and adipogenic precursor cells and then promotes their differentiation.
C3 deficiency can prolong MHC-II molecule mismatched skin allograft survival.
These findings suggest that C3 protects from early glaucomatous damage, a process that may involve EGFR (显示 EGFR 蛋白) signaling and other immune responses in the optic nerve head.
complement C3 or downstream complement activation fragments may play an important role in Abeta (显示 APP 蛋白) plaque pathology.
C5 and C5aR (显示 C5AR1 蛋白) have critical roles in the development of C3 glomerulopathy.
Data show that months after irradiation (IR) complement component 3 (C3-/-) mice made fewer errors than WT mice in a reversal learning test indicating better learning capacity in C3-/- mice after IR.
Time-lapse video microscopy established the localization of the complement anaphylatoxin C3a and its receptor on enteric neural crest cells during their migration in the embryonic gut (显示 GUSB 蛋白). C3a plays a role in regulating collective and directional cell migration, and in ganglia network organization during enteric nervous system ontogenesis. It regulates cell migration in a N-cadherin (显示 CDH2 蛋白)-dependent process.
Retinal C3 was expressed by microglia/macrophages located in the outer retina in AMD (显示 AMD1 蛋白) eyes. In rodent photo-oxidative damage, C3-expressing microglia/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (显示 PTPRC 蛋白)-positive cells in kidney fibrosis.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18 (显示 ITGB2 蛋白)(-/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.
Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (显示 C3AR1 蛋白), revealing an unexpected role of complement proteins in early vertebrate development.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
, C3a anaphylatoxin
, acylation-stimulating protein cleavage product
, complement C3
, complement component C3
, complement component C3a
, complement component C3b
, acylation stimulating protein
, complement component 3d
, complement factor 3
, complement component 3
, complement C3 alpha chain
, complement component C3d