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This study enclosed strong synergistic association of risk genotypes of C3 and CFH (显示 CFH 蛋白) Y402H with AMD (显示 AMD1 蛋白). We also revealed synergistic influence of CCL2 (显示 CCL2 蛋白)-2518 and the at-risk genotype of the C3 in AMD (显示 AMD1 蛋白) with an estimated AP = 50.9% (adjusted AP = 24.7%). Present findings show that CCL2 (显示 CCL2 蛋白)-2518 polymorphism is not an innocent bystander (显示 SEPT1 蛋白) in AMD (显示 AMD1 蛋白) susceptibility when combined with the at-risk genotype of C3 (R102G).
Our study shows C3 to be a relatively strong susceptibility gene for advanced-type-AMD (显示 AMD1 蛋白) (exudative-and-geographic-atrophy) in an Iranian population.
BBB disruption is present in ACS (显示 PLA2G15 蛋白), and elevated levels of IL-6 (显示 IL6 蛋白) and C3 in CSF (显示 CSF2 蛋白) in diffuse NPSLE
This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.
Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR (显示 C3AR1 蛋白), C5aR1 (显示 C5AR1 蛋白) and C5aR2 to direct the cellular response to inflammation.
exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a promoted astrogliogenesis and cell migrationtion.
THP (显示 UMOD 蛋白) appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
Decreased C5a expression is associated with increased inflammation in cystic fibrosis (显示 S100A8 蛋白).
C3d-positive glomerular staining is an independent risk factor for the development of end-stage renal disease in ANCA-associated renal vasculitis.
Factor I binds C3b-Factor H (显示 CFH 蛋白) between Factor H (显示 CFH 蛋白) domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.
Data show that months after irradiation (IR) complement component 3 (C3-/-) mice made fewer errors than WT mice in a reversal learning test indicating better learning capacity in C3-/- mice after IR.
Time-lapse video microscopy established the localization of the complement anaphylatoxin C3a and its receptor on enteric neural crest cells during their migration in the embryonic gut (显示 GUSB 蛋白). C3a plays a role in regulating collective and directional cell migration, and in ganglia network organization during enteric nervous system ontogenesis. It regulates cell migration in a N-cadherin (显示 CDH2 蛋白)-dependent process.
Retinal C3 was expressed by microglia/macrophages located in the outer retina in AMD (显示 AMD1 蛋白) eyes. In rodent photo-oxidative damage, C3-expressing microglia/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (显示 PTPRC 蛋白)-positive cells in kidney fibrosis.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18 (显示 ITGB2 蛋白)(-/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.
Study found that cancer-cell-derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-cerebrospinal fluid (CSF (显示 CSF2 蛋白)) barrier. This effect allows plasma components, including amphiregulin (显示 AREG 蛋白), and other mitogens to enter the CSF (显示 CSF2 蛋白) and promote cancer cell growth.
We induced anti-myeloperoxidase (显示 MPO 蛋白) vasculitis in mice and confirmed a role for complement activation by demonstrating protection in C3-deficient mice.
These data indicated that alpha7-nAChR (显示 CHRNA7 蛋白) caused the inhibition of ASPinduced activation of p38 (显示 CRK 蛋白) kinase and NFkappa B to inhibit the production of MCP1 (显示 CCL2 蛋白) and keratinocytederived chemokine (显示 CCL1 蛋白).
This study provideed the evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain.
Demonstrate that cardiac Sirt1 (显示 SIRT1 蛋白) plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.
Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (显示 C3AR1 蛋白), revealing an unexpected role of complement proteins in early vertebrate development.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.
C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
, C3a anaphylatoxin
, acylation-stimulating protein cleavage product
, complement C3
, complement component C3
, complement component C3a
, complement component C3b
, acylation stimulating protein
, complement component 3d
, complement factor 3
, complement component 3
, complement C3 alpha chain
, complement component C3d