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Neuromyelitis optica patients had higher levels of C3a (显示 C3 蛋白) and anti-C1q antibodies than healthy controls.
Data indicate that Cna binds to C1q.
Analysis of its interaction properties by surface plasmon resonance shows that rC1q retains the ability of serum C1q to associate with the C1s (显示 C1S 蛋白)-C1r-C1r (显示 C1R 蛋白)-C1s (显示 C1S 蛋白) tetramer, to recognize physiological C1q ligands such as IgG and pentraxin 3 (显示 PTX3 蛋白)
Single nucleotide polymorphisms in and around the C1q genes, C1qA (显示 C1QA 蛋白), C1qB (显示 C1QB 蛋白) and C1qC, correlated with C1q serum levels and may be a risk for the development of rheumatoid arthritis.
Three single nucleotide polymorphisms (STAT6 (显示 STAT6 蛋白) rs703817, C1qG rs17433222, and MBP (显示 MBL2 蛋白) rs3794845) were found to be significantly associated with childhood leukemia risk in Koreans.
These results suggest a novel pathway in which C1q and MBL influence removal and metabolism of atherogenic forms of LDL in the early stages of atherosclerosis.
Data show that C1q, C4, C3, and C9 bind to thrombin receptor (显示 F2R 蛋白)-activating peptide-activated platelets in lepirudin-anticoagulated platelet-rich plasma (PRP (显示 C4BPA 蛋白)) and whole blood.
Experiments with recombinant globular head domains of human C1q A, B, and C chains indicated that C1q interacts with PTX3 (显示 PITX3 蛋白) via its globular head region. Binding of C1q to immobilized PTX3 (显示 PITX3 蛋白) induced activation of the classical complement pathway.
The C-terminal globular region of the C1Q C chain may have evolved as a functionally specialized domain or module with distinct binding properties which together with the A and B chains confers versatility and flexibility to the whole C1q molecule.
The structure refined to 1.9 A of resolution of C1q reveals the conformation of subunits A, B, and C and their compact, almost spherical heterotrimeric assembly held together mainly by non-polar interactions, with a Ca2 (显示 CA2 蛋白)+ ion bound at the top.
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. A deficiency in C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N-terminus, and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the C-chain polypeptide of human complement subcomponent C1q. Alternatively spliced transcript variants that encode the same protein have been found for this gene.
complement component 1, q subcomponent, C chain
, complement C1q subcomponent subunit C
, Complement C1q subcomponent subunit C
, complement component 1, q subcomponent, c polypeptide
, complement component 1, q subcomponent, gamma polypeptide