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抗Mouse (Murine) 抗体:
抗Rat (Rattus) 抗体:
the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma.
Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins.
results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex
MCM-BP can decrease phosphorylation by DDK but is not a substrate.
MCM-BP silencing in human cells also delays MCM dissociation in late S phase
Knockdown of the human ETG1 results in defective chromatid cohesion.
MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2.
Xenopus egg extracts, MCM-BP exists in a stable complex with MCM7, but is not associated with the MCM2-7 hexameric complex
This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene.
, mini-chromosome maintenance complex-binding protein
, minichromosome maintenance complex-binding protein