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findings demonstrate a critical role for Etv2-miR (显示 MLXIP ELISA试剂盒)-130a-Jarid2 in vascular patterning both in vitro and in vivo
study suggests that miR (显示 MLXIP ELISA试剂盒)-155 plays a host-damaging role during dextran sulfate sodium-induced colitis mice and induces Th17 differentiation by targeting Jarid2
JARID2 physically interacts with ESRRB (显示 ESRRB ELISA试剂盒), SALL4A (显示 SALL4 ELISA试剂盒), and PRDM14 (显示 PRDM14 ELISA试剂盒)
ESCs (显示 NR2E3 ELISA试剂盒) lacking Jarid2 show constitutive Nanog (显示 NANOG ELISA试剂盒) expression, reduced PCP (显示 BMP1 ELISA试剂盒)/Wnt (显示 WNT2 ELISA试剂盒) signaling and form more than one ICM upon injection to E3.5 mouse blastocysts.
Jarid2 is a novel player in iNKT cell maturation that regulates PLZF expression by modulating H3K9 methylation
Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function
miR (显示 MLXIP ELISA试剂盒)-155 regulates the fate of Th17 and Treg cells and miR (显示 MLXIP ELISA试剂盒)-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2.
Data indicate that upon stimulation of muscle cells with IFN-gamma (显示 IFNG ELISA试剂盒), JARID2 and other members of the Polycomb (显示 CBX2 ELISA试剂盒) repressive complex 2 (PRC2) were recruited to promoters to repress myogenesis.
Jarid2 exhibits nucleosome-binding activity that contributes to PRC2 stimulation
Jarid2 (Jumonji, AT rich interactive domain 2) regulates NOTCH1 (显示 NOTCH1 ELISA试剂盒) expression via histone modification in the developing heart.
JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT (显示 AKT1 ELISA试剂盒) signaling
JARID2 plays an important role in glioma development.
Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility.
JARID2 inhibits leukemia cell proliferation by regulating CCND1 (显示 CCND1 ELISA试剂盒) expression
TGF-ss-dependent expression changes of EMT (显示 ITK ELISA试剂盒)-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression.
Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb (显示 CBX2 ELISA试剂盒) repressive complex 2 (PRC2) activity depending on the chromatin context.
Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2.
The interaction of JARID2 at these promoters is dependent on EED (显示 EED ELISA试剂盒).
This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies.
jumonji, AT rich interactive domain 2
, jumonji, AT rich interactive domain 2 protein
, protein Jumonji-like
, jumonji/ARID domain-containing protein 2
, protein Jumonji
, jumonji homolog
, jumonji-like protein