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Prominent foxp1 expression is detected in many regions of the developing central nervous system, especially in midbrain-hindbrain boundary, hindbrain, and spinal cord.
MiR (显示 MLXIP 蛋白)-92a may act as a tumor inducer in OSCC by suppressing FOXP1 expression.
the varients of FOXP1 and FOXF1 (显示 FOXF1 蛋白) genes are functionally associated with oesophageal adenocarcinoma in Chinese population.
Results show that FOXP1 acts as the functional protein of SNHG12. Its expression is regulated by SNHG12 and miR (显示 MLXIP 蛋白)-101-3p in glioma cells.
Having a SNP in the FOXP1 gene in the absence of Reflux symptoms had an odds ratio of developing Barrett's esophagus of 1.5.
FOXP1 expression is epigenetically regulated by PRMT5 (显示 PRMT5 蛋白).
we have identified a novel de novo missense variant in FOXP1 that is identical to the most well-studied etiological variant in FOXP2 (显示 FOXP2 蛋白). Functional characterization revealed clear similarities between these equivalent mutations in terms of their impact on protein function.
FOXP1-related intellectual disability syndrome (ID) is a recognisable entity with wide clinical spectrum and frequent systemic involvement; more ID and neuromotor delay, sensorineural hearing loss and feeding difficulties are more common in patients with interstitial 3p deletions versus patients with monogenic FOXP1 defects; Mutations result in impaired transcriptional repression and/or reduced protein stability
Prognostic value of decreased FOXP1 protein expression in various tumors, is reported.
Blimp1 (显示 PRDM1 蛋白), Foxp1 and pStat3 are expressed in extranodal diffuse large B-cell lymphomas
Two rare novel FOXP1 variants associated with a phenotype similar to Mental Retardation with Language Impairment and with or without Autistic Features (MIM (显示 MTSS1 蛋白) 613670).
we have shown that the Foxp1 pathway is involved in regulating the migration kinetics of activated CD4 (显示 CD4 蛋白)+ T cells toward B cell follicles, indicating that Foxp1 is involved in Tfh cell differentiation from the beginning of a CD4 (显示 CD4 蛋白)+ T cell response.
These results identify Foxp1 as a physiological regulator of mature B cell survival mediated in part via the control of Bcl-xl (显示 BCL2L1 蛋白) expression and imply that this pathway might contribute to the pathogenic function of aberrant Foxp1 expression in lymphoma.
FOXP1-knockdown in utero reduces NSC differentiation and migration during corticogenesis. FOXP1 represses expression of Notch (显示 NOTCH1 蛋白) pathway genes.
Foxp1 has a putative HuR (显示 ELAVL1 蛋白) binding sites in the 3' UTR. HuR (显示 ELAVL1 蛋白) suppresses Foxp1 translation during early neocortical neurogenesis (E13). In HuR (显示 ELAVL1 蛋白) knockout mice, decreased Foxp1 mRNA was paralleled by increased Foxp1 protein at E13. Phosphorylation sites on HuR (显示 ELAVL1 蛋白) act in post-transcriptional regulation of Foxp1.
Study identified the roles of Foxo1 as a positive regulator and Foxp1 as a negative regulator of TH9 cell differentiation and antitumor activity.
deletion of Foxp1 in the developing forebrain leads to impairments in neonatal vocalizations as well as neocortical cytoarchitectonic alterations via neuronal positioning and migration
Foxp1 conditional knock-out (Foxp1(cKO)) mice with loss of Foxp1 in the neocortex and hippocampus display autism and intellectual-disability-relevant behaviors
These results indicate that FOXP1 attenuates MSC (显示 MSC 蛋白) senescence by orchestrating their cell-fate switch while maintaining their replicative capacity in a dose- and age-dependent manner.
Although the mutant huntingtin (显示 HTT 蛋白) gene is expressed widely, neurons of the striatum and cortex are selectively affected in Huntington's disease (HD). Our results suggest that this selectivity is attributable to the reduced expression of Foxp1, a protein expressed selectively in striatal and cortical neurons that plays a neuroprotective role in these cells.
studies suggest that Foxp1 enforces naive CD8 (显示 CD8A 蛋白)(+) T cell quiescence by simultaneously repressing key pathways in both cellular metabolism and cell cycle progression
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms.
forkhead box P1
, forkhead box protein P1-B
, forkhead box protein P1-like
, forkhead box protein P1
, fork head-related protein like B
, glutamine-rich factor 1
, forkhead-related transcription factor 1