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Foxc1 promoted cell proliferation by upregulation PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) signaling, which was inflammation-dependent.
Knockdown of FOXC1 markedly suppressed cell migration and invasion in vitro, and resulted in downregulation of phosphorylatedRACalpha serine/threonineprotein kinase, protooncogene cMyc (显示 MYC 蛋白) and Bcell lymphoma 2.
Results provide evidence that FOXC1 is not required for initiation of EMT (显示 ITK 蛋白) events but rather participates in the specification of mesenchymal cell phenotype through regulation of FGF receptor (显示 FGFR2 蛋白) switching from FGFR2 (显示 FGFR2 蛋白)-IIIb to FGFR1 (显示 FGFR1 蛋白)-IIIc in response to TGFb1 (显示 TGFB1 蛋白)-induced EMT (显示 ITK 蛋白).
In regulating cervical cancers metastasis by targeting FOXC1.
Forkhead box C1 protein (FOXC1) promotes melanoma cell function by regulating macrophage stimulating 1 receptor (MST1R (显示 MST1R 蛋白)) and activating MST1R (显示 MST1R 蛋白)/PI3K (显示 PIK3CA 蛋白)/AKT (显示 AKT1 蛋白) pathway.
expression of FOXC1 in BRCA1 mutant cell lines correlates with sensitivity to olaparib. Whether this is due to rates of proliferation or another mechanism is yet to be explored, but this, and the specificity of FOXC1 in BRCA1-mutant tumors, suggests a possible role for FOXC1 as a marker for targeted therapy.
novel EGFR (显示 EGFR 蛋白)-NF-kappaB (显示 NFKB1 蛋白)-FOXC1 signaling axis that is critical for BLBC cell function
Taken together, these data indicate that FOXC1 is a novel hypoxia-induced transcription factor and plays a critical role in tumor microenvironment-promoted lung cancer progression.
Genomic analysis of blood and excised valve tissue showed down-regulation of FOXC1 but also FOXC2 (显示 FOXC2 蛋白) expression in the diseased aortic valve. This allows us to speculate on the potential role of FOXC1 in aortic valve anomalies.
Results showed a significant higher FOXC1 expression in estrogen receptor (显示 ESR1 蛋白)-negative breast cancer than that in estrogen receptor (显示 ESR1 蛋白)-positive. Its overexpression reduced expression of ERalpha (显示 ESR1 蛋白) and cellular responses to tamoxifen suggesting that FOXC1 regulated expression of ERalpha (显示 ESR1 蛋白) and affected sensitivity of tamoxifen treatment in breast cancer
Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype.
Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes.
FOXC1 and FOXC2 (显示 FOXC2 蛋白) are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
These data indicate that Foxc1 expression is regulated by BMP4 (显示 BMP4 蛋白) and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria.
Compound, NC-specific Foxc1; Foxc2 (显示 FOXC2 蛋白) homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (显示 PITX2 蛋白), and its downstream effector Dkk2 (显示 DKK2 蛋白), which antagonizes canonical Wnt (显示 WNT2 蛋白) signaling.
These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations.
Foxc1 and Foxc2 (显示 FOXC2 蛋白) maintain glomerular podocyte integrity by regulating the gene expression.
Foxc1 and Foxc2 (显示 FOXC2 蛋白) have a role in kidney and axial skeleton development.
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.
Identify mesodermal foxc1a/b as a direct upstream regulator of etsrp (显示 ETV2 蛋白) in angioblasts. This establishes a new molecular link in the process of mesoderm specification into angioblast.
This study reveals an important role for FOXC1 in the direct regulation of the FGF19 (显示 FGF19 蛋白)-FGFR4 (显示 FGFR4 蛋白)-MAPK (显示 MAPK1 蛋白) pathway to promote both the development and maintenance of anterior segment structures within the eye.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
forkhead box protein C1
, forkhead, drosophila, homolog-like 7
, forkhead-related activator 3
, forkhead-related protein FKHL7
, forkhead-related transcription factor 3
, forkhead/winged helix-like transcription factor 7
, myeloid factor-delta
, forkhead box C1
, forkhead box protein C1-B
, Forkhead box protein C1
, congenital hydrocephalus
, mesoderm/mesenchyme forkhead 1
, transcription factor FKH-1
, winged helix protein CWH-6
, winged-helix transcription factor
, forkhead box C1-B